General information for g423.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Acetyl-CoA acetyltransferase B, mitochondrial.
Parent gene
- The parent gene g423 is located on chr_3: 3310625..3312206 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g423 | g423.t2 | TSS | g423.t2 | 3308254 | 3308254 |
| chr_3 | g423 | g423.t2 | isoform | g423.t2 | 3308286 | 3309274 |
| chr_3 | g423 | g423.t2 | exon | g423.t2.exon1 | 3308286 | 3308538 |
| chr_3 | g423 | g423.t2 | cds | g423.t2.CDS1 | 3308286 | 3308538 |
| chr_3 | g423 | g423.t2 | exon | g423.t2.exon2 | 3308603 | 3309274 |
| chr_3 | g423 | g423.t2 | cds | g423.t2.CDS2 | 3308603 | 3309273 |
| chr_3 | g423 | g423.t2 | TTS | g423.t2 | NA | NA |
Sequences
>g423.t2 Gene=g423 Length=925
ATGGCATTTTCTATGAGATTAGCAAGAACAACAAGTCAAAATTTCCGATCATATTCGAGT
GGAAGAAAATTTAATGATGTAGTTATAGTTTCAGCAACACGAACTCCAATTGGTTCATTT
CAATCTTCATTACAATCACTTTCTGCAAGTCAATTAGGTGGCATTGCAATTCAATCAGCA
ATCAAACAAGCAGGAATTAGAAATGAGGATGTAGATGAAGTATTAATGGGAAATGTTGTC
TCTGTTGGAATGGGACAAGCACCAGCACGACAGGCAGCAATTTTCGCTGGTCTTCCAACT
TCTGTTTGCTGTACAACAATCAATAAAGTTTGCAGCAGTGGCCTAAAAACAGTTTCACTT
GCAGCACAAACACTTATGTTAGGTCAGGGTCAAGAAGTCATCGTCGCAGGTGGAATGGAA
TCAATGAGTAATGTGCCTTATTATTTAAAAAGAGGTTCAACACCCTATGGTGGAGTGAAT
TTAATTGATGGCATTGTTCATGATGGTTTATGGGATCCATATAACAAATTTCACATGGGT
AATTGTGCTGAAAATACAGCAAAAAAACTTGGAATTACAAGACAGCAACAAGATGAATAT
GGAATTTCAAGCTACAAACGATCAGCTGAAGCATGGAAAAATAAAATTTTTGATGCAGAA
ATCACACAAGTTTCAATTCCACAAAAGAAAGGCAAACCTGATATTGTAATTACAGAAGAT
GAGGAATATAAAAGAGTTAATTTTGATAAATTTGGCAGCTTGGGAACAGTCTTTCAAAAA
GAAAATGGAACAGTTACTGCTGGTAATGCAAGTACATTAAATGATGGTGGAGCAGCTTTA
GTCCTAATGACAGCTGAAGCTGCAGAAAAACATAAATGTAAACCACTCGCTCAAGTTGTT
GGCTTTGCTGATGCTGAAACTGATC
>g423.t2 Gene=g423 Length=308
MAFSMRLARTTSQNFRSYSSGRKFNDVVIVSATRTPIGSFQSSLQSLSASQLGGIAIQSA
IKQAGIRNEDVDEVLMGNVVSVGMGQAPARQAAIFAGLPTSVCCTTINKVCSSGLKTVSL
AAQTLMLGQGQEVIVAGGMESMSNVPYYLKRGSTPYGGVNLIDGIVHDGLWDPYNKFHMG
NCAENTAKKLGITRQQQDEYGISSYKRSAEAWKNKIFDAEITQVSIPQKKGKPDIVITED
EEYKRVNFDKFGSLGTVFQKENGTVTAGNASTLNDGGAALVLMTAEAAEKHKCKPLAQVV
GFADAETD
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g423.t2 | CDD | cd00751 | thiolase | 28 | 308 | 2.64031E-117 |
| 6 | g423.t2 | Gene3D | G3DSA:3.40.47.10 | - | 17 | 308 | 1.1E-92 |
| 2 | g423.t2 | PANTHER | PTHR18919:SF156 | ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL | 16 | 308 | 1.8E-138 |
| 3 | g423.t2 | PANTHER | PTHR18919 | ACETYL-COA C-ACYLTRANSFERASE | 16 | 308 | 1.8E-138 |
| 1 | g423.t2 | Pfam | PF00108 | Thiolase, N-terminal domain | 27 | 285 | 3.9E-86 |
| 5 | g423.t2 | ProSitePatterns | PS00098 | Thiolases acyl-enzyme intermediate signature. | 107 | 125 | - |
| 4 | g423.t2 | SUPERFAMILY | SSF53901 | Thiolase-like | 26 | 292 | 1.71E-71 |
| 7 | g423.t2 | TIGRFAM | TIGR01930 | AcCoA-C-Actrans: acetyl-CoA C-acyltransferase | 29 | 305 | 1.4E-81 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016746 | acyltransferase activity | MF |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
