General information for g4344.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Uricase .
Parent gene
- The parent gene g4344 is located on chr_2: 1426325..1432855 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g4344 | g4344.t1 | TSS | g4344.t1 | 1425138 | 1425138 |
| chr_2 | g4344 | g4344.t1 | isoform | g4344.t1 | 1425198 | 1426325 |
| chr_2 | g4344 | g4344.t1 | exon | g4344.t1.exon1 | 1425198 | 1425294 |
| chr_2 | g4344 | g4344.t1 | cds | g4344.t1.CDS1 | 1425198 | 1425294 |
| chr_2 | g4344 | g4344.t1 | exon | g4344.t1.exon2 | 1425359 | 1425712 |
| chr_2 | g4344 | g4344.t1 | cds | g4344.t1.CDS2 | 1425359 | 1425712 |
| chr_2 | g4344 | g4344.t1 | exon | g4344.t1.exon3 | 1425779 | 1425905 |
| chr_2 | g4344 | g4344.t1 | cds | g4344.t1.CDS3 | 1425779 | 1425905 |
| chr_2 | g4344 | g4344.t1 | exon | g4344.t1.exon4 | 1425974 | 1426325 |
| chr_2 | g4344 | g4344.t1 | cds | g4344.t1.CDS4 | 1425974 | 1426325 |
| chr_2 | g4344 | g4344.t1 | TTS | g4344.t1 | 1426502 | 1426502 |
Sequences
>g4344.t1 Gene=g4344 Length=930
ATGCCAATCAATAATCAAATGCAGGATAGTAAGTTTGTTATCGATAAAACAAATTATGGT
AAGACTGGAGTGAAAATTCTTCATCTTGTTAGAAATGGTCTAGTTCATACTGTTAAAGAA
TATGAAGTGACAACACTTCTTACACTCGATACACTAAAAGATTTTATGCAAGCTGACAAC
TCTGACATCATTGCCACTGACTCGCAGAAAAACACTGTCTATATTCTTGCTAAGAAGTAT
GGCATAAAATCCCCAGAGGATTTCGGAATTTTATTGAGTTCTCATTTTATCACCAAATAT
GCGCACGTGACGAAAGCTGTAGTGAATATTCAAGAAGTCATGTGGAATAGAGTGAGTTAT
GGCGATCATGCAAATAGCAAGTTGCATAATCATGCCTTCATTCATACACCAATATGTACG
AGAATCACGAATGTTGTTCTTAATCGCGAAGATAAATATCCATCTATCTCAAGTGGAATC
AAAGATTTGCGTGTTTTAAAAACGACACAAAGTTCTTTTATGAATTTTGTTAATGATGAA
TATCGCTCGCTGCCAGACGCTGATGATAGAATTTTTAGTACAATCGTTGATTGCTCTTGG
ATTTATTCGCCAAATCCAAATGTTGATTTTTGTAAAGTTTTTGATTCTGTAAAAAATTCC
ATTATATTTAATTTTGCTGGTGATCTAGAAAAGGGAATTGCATCAGCAAGTGTTCAAAAT
ACAATTTATATCACTGAAAAAGATGTTCTTGAGAAAATCAAAGATATTAAATCTATTGAA
ATGACGCTGCCAAATAAGCATTATATTAACTTTAATTTTGCACCCTTTAAGTCGATTGTT
TATGACGATGAACAGACTGTTTTCATCCCATTAGATAAACCATCAGGTGTCATTTATGCA
AAATTGGATAGAAAAATAAGTAAACTGTAA
>g4344.t1 Gene=g4344 Length=309
MPINNQMQDSKFVIDKTNYGKTGVKILHLVRNGLVHTVKEYEVTTLLTLDTLKDFMQADN
SDIIATDSQKNTVYILAKKYGIKSPEDFGILLSSHFITKYAHVTKAVVNIQEVMWNRVSY
GDHANSKLHNHAFIHTPICTRITNVVLNREDKYPSISSGIKDLRVLKTTQSSFMNFVNDE
YRSLPDADDRIFSTIVDCSWIYSPNPNVDFCKVFDSVKNSIIFNFAGDLEKGIASASVQN
TIYITEKDVLEKIKDIKSIEMTLPNKHYINFNFAPFKSIVYDDEQTVFIPLDKPSGVIYA
KLDRKISKL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g4344.t1 | Gene3D | G3DSA:3.10.270.10 | Urate Oxidase; | 3 | 309 | 3.4E-107 |
| 3 | g4344.t1 | PANTHER | PTHR42874 | URICASE | 11 | 309 | 1.5E-101 |
| 12 | g4344.t1 | PIRSF | PIRSF000241 | Urate_oxidase | 3 | 309 | 3.5E-103 |
| 8 | g4344.t1 | PRINTS | PR00093 | Uricase signature | 20 | 31 | 3.5E-27 |
| 4 | g4344.t1 | PRINTS | PR00093 | Uricase signature | 59 | 73 | 3.5E-27 |
| 6 | g4344.t1 | PRINTS | PR00093 | Uricase signature | 95 | 108 | 3.5E-27 |
| 7 | g4344.t1 | PRINTS | PR00093 | Uricase signature | 163 | 179 | 3.5E-27 |
| 5 | g4344.t1 | PRINTS | PR00093 | Uricase signature | 179 | 191 | 3.5E-27 |
| 2 | g4344.t1 | Pfam | PF01014 | Uricase | 18 | 145 | 3.1E-36 |
| 1 | g4344.t1 | Pfam | PF01014 | Uricase | 157 | 298 | 9.7E-27 |
| 13 | g4344.t1 | ProSitePatterns | PS00366 | Uricase signature. | 163 | 190 | - |
| 9 | g4344.t1 | SUPERFAMILY | SSF55620 | Tetrahydrobiopterin biosynthesis enzymes-like | 14 | 147 | 2.0E-40 |
| 10 | g4344.t1 | SUPERFAMILY | SSF55620 | Tetrahydrobiopterin biosynthesis enzymes-like | 154 | 305 | 7.78E-46 |
| 14 | g4344.t1 | TIGRFAM | TIGR03383 | urate_oxi: urate oxidase | 15 | 304 | 7.3E-93 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0006144 | purine nucleobase metabolic process | BP |
| GO:0055114 | NA | NA |
| GO:0004846 | urate oxidase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K00365 (urate oxidase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed