General information for g4373.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Kinase D-interacting substrate of 220 kDa.
Parent gene
- The parent gene g4373 is located on chr_2: 1711498..1715094 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g4373 | g4373.t1 | TTS | g4373.t1 | 1708811 | 1708811 |
| chr_2 | g4373 | g4373.t1 | isoform | g4373.t1 | 1709576 | 1715094 |
| chr_2 | g4373 | g4373.t1 | exon | g4373.t1.exon1 | 1709576 | 1709893 |
| chr_2 | g4373 | g4373.t1 | cds | g4373.t1.CDS1 | 1709576 | 1709893 |
| chr_2 | g4373 | g4373.t1 | exon | g4373.t1.exon2 | 1710454 | 1710651 |
| chr_2 | g4373 | g4373.t1 | cds | g4373.t1.CDS2 | 1710454 | 1710651 |
| chr_2 | g4373 | g4373.t1 | exon | g4373.t1.exon3 | 1710710 | 1710877 |
| chr_2 | g4373 | g4373.t1 | cds | g4373.t1.CDS3 | 1710710 | 1710877 |
| chr_2 | g4373 | g4373.t1 | exon | g4373.t1.exon4 | 1710987 | 1711270 |
| chr_2 | g4373 | g4373.t1 | cds | g4373.t1.CDS4 | 1710987 | 1711270 |
| chr_2 | g4373 | g4373.t1 | exon | g4373.t1.exon5 | 1711328 | 1711506 |
| chr_2 | g4373 | g4373.t1 | cds | g4373.t1.CDS5 | 1711328 | 1711506 |
| chr_2 | g4373 | g4373.t1 | exon | g4373.t1.exon6 | 1711575 | 1712362 |
| chr_2 | g4373 | g4373.t1 | cds | g4373.t1.CDS6 | 1711575 | 1712362 |
| chr_2 | g4373 | g4373.t1 | exon | g4373.t1.exon7 | 1712420 | 1713322 |
| chr_2 | g4373 | g4373.t1 | cds | g4373.t1.CDS7 | 1712420 | 1713322 |
| chr_2 | g4373 | g4373.t1 | exon | g4373.t1.exon8 | 1713508 | 1714382 |
| chr_2 | g4373 | g4373.t1 | cds | g4373.t1.CDS8 | 1713508 | 1714382 |
| chr_2 | g4373 | g4373.t1 | exon | g4373.t1.exon9 | 1714500 | 1715094 |
| chr_2 | g4373 | g4373.t1 | cds | g4373.t1.CDS9 | 1714500 | 1715094 |
| chr_2 | g4373 | g4373.t1 | TSS | g4373.t1 | NA | NA |
Sequences
>g4373.t1 Gene=g4373 Length=4308
ATGAAAGAAACTGAATATAATGGAGGAAGAAATATGTTGGATTATTTTAAACTTACTTTA
ACATTCCAGGGCTTAAATCGTGTTGACTCCTCCATGGGATCATTCTCGCATCGTACTTTA
TTAAATTTCATTGAAAACGATGATATAGTCGGATTTAAAGGATTTCTCGACACCCATCAA
ATACAAGTCGACGACCGCGATGAAAACGGAACGACTGTGCTTATGGTTTGTGCGACAAAA
GGTCTAATACAATTTGTTCGTGAGCTAATCAGTCACGGATCGGATGTAAATTTACAAGAT
CTTGATAACTGGACAGCTCTTTTGTGTGCAGCTAAAACAGGGCATTTAGAGATAATTGAA
ATTCTTCTCGAAAATGGAGCAAACATTGAACAACGTGATATGGGCAATTGGACGGCTTTG
ATGTGGGCAGCTTATAAAGGTCATACACAGGTCGTTCAATTTTTGCTCGAACATAATGCT
GATGTTAATGTTAATGGAAATTATCACATCTCTCCACTCTTGTGGGCATGCGGCAGAGGC
TATACTGACATTGTTCAAATGCTTGTACAACGTGGGGCAAAAATTAATGTCGGTGATAAA
TATGGTACAACAGCACTTGTATGGGCTTGCAGGAAAGGAAATGCGGAAATTGTCGATATT
CTTTTGAAGGCTAATGCATCAGTTGATAGTGCGGGAATGTATTCATGGACGCCATTGCTT
GTAGCAACATCTGGAGGGCATCTTGATTGTGTCGCTCTTTTATTAGAAAGAAAACCAAAT
GTCAATGCAATGGATAAAGATGGTCAAACGGCTCTAGCTGTAGCATGTAAGGAAGGATTT
CAGGAGATAGCGTCTGCATTGATTGCGTCAGGAGCCTATCTCAATTCACAAGATCGTAAT
GGTGACACTCCTTTAATCAACGCTGTAAAAGCAGGTCATCGTGGCATTTGCGAAGCTTTA
TTAAAACGACACATAGATATTGACTTGCAAGGAAAAGATAAGAAAACCGCATTGTATACA
GCAGTTGAGAAAGGACATGTTGCCATCGTAAAGCTTTTATTAAGTTCAAATCCAGATATC
GAATTGCCTAATAAAGATGGTGAAACAGCATTACATCGAGCCGTTCGTAGTCGTAATCTA
GAGATTGTGCAAATGTTGCTTGAAAAGCGAGCGAAAGTAGGTGCTGTTGATCGTCGAGGT
GACACATGCTTGCATATTGCTATGCGTGCTAGATCGAAGGCTATTGTAGAGGCATTATTG
AGAAATCCCAAAAACAGTCAATTATTATATCGTGCTAATAAAGCTGGTGAAACAGCATAT
GCATTAGATGCTCTTCATCAAAAAACAATTCTTGGTCAAGTGTTTGGAGCAAGAAAACTT
AATACCAATGAAGATTCAGAAGGAATGCTTGGATATGGTCTTTATTCTTCTGCTTTGGCA
GATGTTTTAAGTGAACCAACTTTATCAACTCCGATTACTGTTGGTTTATACGCAAAATGG
GGCAGTGGTAAAAGCTTTCTACTCACAAAACTGCGAGAGGAAATGACTTGCTTCAGTCGT
CAATGGAGCGAGCCACAAATACAAGCAACATGGCTCATTGTGTTGTTATCAATTCATTTA
TCTCTATTTTCGGGCATCATCGTGGCTTTATCCACATGGTCAGTGCTTTATGGATCAATT
ACTACAGCTTCCTTGCTTATATTGATGTATTCAATTTCATTGCTGTTGAAATTTGTGAAT
CGACGATACAATTTCGATTGGTCATACAACTTACATCATTCGTTTTTGAAGAAAATTGGG
AAATTTCGTTTGATTTTGCAAGTGGCCTTTTGTCATCCTCCTGGGCCATTACATTCTTCA
CAAGCGAGTGCAATACAAACGATGCCTGTACGATTTCATTTTTCGGAAACAAATAGTGCA
GCACCAAATGGTGAGAGTGCTTTAGGTTACATGCTTGCCGCTTTATTTACTGCTATTGAA
AACTATTATGGAGCCATTCCGACGAGACTCTTTCGAGCTTTCAATAAAACGATCAAGCCA
GTAAAACCCTCATCAAATTGGAGATTTAGGAAAATGTGTTGCGTTCCAATATTTGTATTA
TTTGAGTTATTCATTTTTGCGGCTATAGCAGGGATATCATTACTTATAATGTGGTTTTTC
CATGCAGACGATTCCGAGTCGAAAAATCAAATTGAAATTTCACTCTATGTTCTTGCAACT
GTGCTAGTTTTAGGCGCATTTTTCAATTTAAATGCATGGACAAAAGCATTCAAAACAATA
TTCTTCTCACAAGGGCGCTATTTAAAGCAAATAATGAAAACTAATGATGGTTTAACAGCA
TTAAGTGGTGAAGTTATGATGATGGCAGATATGGTTCGATGTCTTGATTCTTTTACTGGT
CAACAAAGTCGTCTCGTTGGTGTCGTTGATACACTAGACTCATGCGACACAGAACGAACA
TTGAGTATATTGAATGGAATTCAAACGTTGTTGATGACACCACCTAATCGACCATTTGTT
TTGTTACTCGCAGTTGACCCACATGTGGTTGCAAAAGCAGCTGAAAACAATAGTAAAAGA
TTGTTCACAGAGGGTGGTATAGGTGGTCATGATTTCCTGAGAAATCTCGTACATCTGCCT
GTTTATCTACAAAATTCAGGCCTGCGAAAAGTTCAGCGTGCACAGACAACTGCTATGCAG
TATAAACGTGTGCTTTCAGACACATATGATGATGTTGGAATATCATATTCGGCTTCACAT
CGACGACTATCGAATGCATCAGAAATTATGGCTAGTACAGAAAAATTGAGAGGAATTTCA
AGAGGTTCCAAAAAATTGAAACTTTCAGAGTCAATTGCGAGCTCAATTGGATCAAATATC
CACAAGCTTGGCGGTAATCAATTCGAATTTTCTAAAGTTATGCTCACCGATGATTATTTC
AGCGATGTAAACCCAAGAAGCATGCGACGCCTTATGAATGTCATTTATATTACTGTGCGA
TTACTAAAAGCATTTCAAATTGACTTTAGTTGGTATAGATTGGGTTCTTGGATAAATTTA
ACGGAGCAATGGCCACTTCGTGCTAGTATGATTGTACTTGAGCATGATCAGAGTGGAGAA
AATTTAGATGAAACAATCTCACTGCAGTCATTGTACGAGAAAGTTAGACCAAAATTATCA
TGCTTGCGTGAAGCTGCTCCATTACTCGATTTAGATCGTGATGAAAGGAAATTGGATGCA
TTTTTACAGCTACATAAATCAGATTTGCAAGTTTCCGATTTGAGAATTTTTCTTCCATTC
ACAATAAATTTAGATCCTTACTTGAGAAAAGTTTTGAAAGAGGACCAACAAACATTGGAA
GATGAAGGAATAATTTTTCCTATGAAAACAAATACGCCACAATTACCACCACAAATGCCT
AGTCTTTACAATCGTAATCAGAATGCATATTTTCAAGCCACACAACCAGCTTTTGTTCCA
CAACTTCCTTTGTATCAAACGAATCCTTCTATTACTATGATGAATTATTTTAATGCAGCA
TCAAATCGTCAACAGCAACAACAAATTAATCAAGTAGAGCATACTGAAAATTCATTTCTA
CAGCAACATATTCCTGTCGACATGGATTTGTCACAAATAAAATTATCAAAATTGAGTTGT
GACGATTTGACAAATTTGCTTAGTCAAGTTAGTGAATTAAAAATGGCAATTGAAAGTTTA
GGACCATTATTGAAAGAAAATGCGATAACAGGAAGAGTTCTTATGTATTGTGATTTGAAT
GAATTAAAATCGGTCCTCAAATTAAATTTTGGACATTGGGAAATTTTTAAAATGCTTGTT
TTGAGTCTTCGTGAAGGAGAAAATGCAACCAAGATTCCTGTTGTTACATTTAAAAATGAT
CAAAAGGACATGAATGATGGACCATCAACAAGTATGCAACAAGTTCCAGTAATAAGTCGA
ATAAAACAAAAGAGTGTTATCGAAAAACAGGTAACTCTGGAGCAGGAAATGATTTGCGGT
GCGTTATCAACTTTAAATGAGGATGCTTTCGAAGATGTAACCTTATCAAATCCTAATCCA
TCGTCGTCATCAAATGGATCTACAGGTGAGCTTATTCTTCAGCAAAATTATCTGGCACCA
ATAACTGAAGAGTTTGGCTCTCCAACTCCATCGCGGAGTTTTGATAGCTTCTTTGATGAT
GCTAATCAGTTTGAAGTTGTTAATAACATTAATCGCAATAACAATAATGAATCAACAGTC
ATCATTATGCCTAATTTTCCAACAAATATTGATGACACACGCTTATAA
>g4373.t1 Gene=g4373 Length=1435
MKETEYNGGRNMLDYFKLTLTFQGLNRVDSSMGSFSHRTLLNFIENDDIVGFKGFLDTHQ
IQVDDRDENGTTVLMVCATKGLIQFVRELISHGSDVNLQDLDNWTALLCAAKTGHLEIIE
ILLENGANIEQRDMGNWTALMWAAYKGHTQVVQFLLEHNADVNVNGNYHISPLLWACGRG
YTDIVQMLVQRGAKINVGDKYGTTALVWACRKGNAEIVDILLKANASVDSAGMYSWTPLL
VATSGGHLDCVALLLERKPNVNAMDKDGQTALAVACKEGFQEIASALIASGAYLNSQDRN
GDTPLINAVKAGHRGICEALLKRHIDIDLQGKDKKTALYTAVEKGHVAIVKLLLSSNPDI
ELPNKDGETALHRAVRSRNLEIVQMLLEKRAKVGAVDRRGDTCLHIAMRARSKAIVEALL
RNPKNSQLLYRANKAGETAYALDALHQKTILGQVFGARKLNTNEDSEGMLGYGLYSSALA
DVLSEPTLSTPITVGLYAKWGSGKSFLLTKLREEMTCFSRQWSEPQIQATWLIVLLSIHL
SLFSGIIVALSTWSVLYGSITTASLLILMYSISLLLKFVNRRYNFDWSYNLHHSFLKKIG
KFRLILQVAFCHPPGPLHSSQASAIQTMPVRFHFSETNSAAPNGESALGYMLAALFTAIE
NYYGAIPTRLFRAFNKTIKPVKPSSNWRFRKMCCVPIFVLFELFIFAAIAGISLLIMWFF
HADDSESKNQIEISLYVLATVLVLGAFFNLNAWTKAFKTIFFSQGRYLKQIMKTNDGLTA
LSGEVMMMADMVRCLDSFTGQQSRLVGVVDTLDSCDTERTLSILNGIQTLLMTPPNRPFV
LLLAVDPHVVAKAAENNSKRLFTEGGIGGHDFLRNLVHLPVYLQNSGLRKVQRAQTTAMQ
YKRVLSDTYDDVGISYSASHRRLSNASEIMASTEKLRGISRGSKKLKLSESIASSIGSNI
HKLGGNQFEFSKVMLTDDYFSDVNPRSMRRLMNVIYITVRLLKAFQIDFSWYRLGSWINL
TEQWPLRASMIVLEHDQSGENLDETISLQSLYEKVRPKLSCLREAAPLLDLDRDERKLDA
FLQLHKSDLQVSDLRIFLPFTINLDPYLRKVLKEDQQTLEDEGIIFPMKTNTPQLPPQMP
SLYNRNQNAYFQATQPAFVPQLPLYQTNPSITMMNYFNAASNRQQQQQINQVEHTENSFL
QQHIPVDMDLSQIKLSKLSCDDLTNLLSQVSELKMAIESLGPLLKENAITGRVLMYCDLN
ELKSVLKLNFGHWEIFKMLVLSLREGENATKIPVVTFKNDQKDMNDGPSTSMQQVPVISR
IKQKSVIEKQVTLEQEMICGALSTLNEDAFEDVTLSNPNPSSSSNGSTGELILQQNYLAP
ITEEFGSPTPSRSFDSFFDDANQFEVVNNINRNNNNESTVIIMPNFPTNIDDTRL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g4373.t1 | Gene3D | G3DSA:1.25.40.20 | - | 37 | 166 | 3.5E-37 |
| 12 | g4373.t1 | Gene3D | G3DSA:1.25.40.20 | - | 167 | 258 | 3.6E-30 |
| 11 | g4373.t1 | Gene3D | G3DSA:1.25.40.20 | - | 259 | 367 | 7.8E-33 |
| 10 | g4373.t1 | Gene3D | G3DSA:1.25.40.20 | - | 368 | 454 | 2.3E-16 |
| 7 | g4373.t1 | PANTHER | PTHR24123:SF50 | - | 24 | 1369 | 0.0 |
| 8 | g4373.t1 | PANTHER | PTHR24123 | ANKYRIN REPEAT-CONTAINING | 24 | 1369 | 0.0 |
| 3 | g4373.t1 | Pfam | PF12796 | Ankyrin repeats (3 copies) | 64 | 133 | 4.9E-12 |
| 2 | g4373.t1 | Pfam | PF12796 | Ankyrin repeats (3 copies) | 136 | 199 | 4.6E-12 |
| 4 | g4373.t1 | Pfam | PF12796 | Ankyrin repeats (3 copies) | 201 | 265 | 1.5E-10 |
| 6 | g4373.t1 | Pfam | PF00023 | Ankyrin repeat | 267 | 298 | 0.024 |
| 1 | g4373.t1 | Pfam | PF12796 | Ankyrin repeats (3 copies) | 332 | 395 | 2.0E-13 |
| 5 | g4373.t1 | Pfam | PF07693 | KAP family P-loop domain | 472 | 1002 | 2.2E-93 |
| 16 | g4373.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1 | 528 | - |
| 22 | g4373.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 529 | 550 | - |
| 18 | g4373.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 551 | 555 | - |
| 19 | g4373.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 556 | 576 | - |
| 14 | g4373.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 577 | 696 | - |
| 21 | g4373.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 697 | 721 | - |
| 17 | g4373.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 722 | 732 | - |
| 20 | g4373.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 733 | 753 | - |
| 15 | g4373.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 754 | 1435 | - |
| 38 | g4373.t1 | ProSiteProfiles | PS50297 | Ankyrin repeat region circular profile. | 62 | 422 | 103.676 |
| 45 | g4373.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 69 | 101 | 10.793 |
| 40 | g4373.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 102 | 134 | 12.716 |
| 43 | g4373.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 135 | 167 | 11.674 |
| 39 | g4373.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 168 | 200 | 10.793 |
| 41 | g4373.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 201 | 233 | 10.286 |
| 42 | g4373.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 234 | 266 | 10.232 |
| 47 | g4373.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 267 | 299 | 10.82 |
| 48 | g4373.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 300 | 332 | 9.805 |
| 44 | g4373.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 333 | 365 | 10.98 |
| 46 | g4373.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 366 | 398 | 12.957 |
| 28 | g4373.t1 | SMART | SM00248 | ANK_2a | 69 | 98 | 0.012 |
| 34 | g4373.t1 | SMART | SM00248 | ANK_2a | 102 | 131 | 8.0E-6 |
| 33 | g4373.t1 | SMART | SM00248 | ANK_2a | 135 | 164 | 3.7E-6 |
| 32 | g4373.t1 | SMART | SM00248 | ANK_2a | 168 | 197 | 9.5E-4 |
| 30 | g4373.t1 | SMART | SM00248 | ANK_2a | 201 | 230 | 3.2E-4 |
| 27 | g4373.t1 | SMART | SM00248 | ANK_2a | 234 | 263 | 2.5E-4 |
| 37 | g4373.t1 | SMART | SM00248 | ANK_2a | 267 | 296 | 0.5 |
| 35 | g4373.t1 | SMART | SM00248 | ANK_2a | 300 | 329 | 0.015 |
| 31 | g4373.t1 | SMART | SM00248 | ANK_2a | 333 | 362 | 1.8E-4 |
| 36 | g4373.t1 | SMART | SM00248 | ANK_2a | 366 | 395 | 2.2E-4 |
| 29 | g4373.t1 | SMART | SM00248 | ANK_2a | 399 | 428 | 0.45 |
| 9 | g4373.t1 | SUPERFAMILY | SSF48403 | Ankyrin repeat | 58 | 438 | 8.3E-97 |
| 23 | g4373.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 527 | 549 | - |
| 26 | g4373.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 554 | 576 | - |
| 25 | g4373.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 698 | 720 | - |
| 24 | g4373.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 733 | 752 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005515 | protein binding | MF |
KEGG
Orthology
- This transcript has been annotated with K12460 (ankyrin repeat-rich membrane spanning protein)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
