Gene loci information

Transcript annotation

  • This transcript has been annotated as Tyrosine-protein kinase Dnt.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_2 g4741 g4741.t2 isoform g4741.t2 4579180 4581305
chr_2 g4741 g4741.t2 exon g4741.t2.exon1 4579180 4579723
chr_2 g4741 g4741.t2 cds g4741.t2.CDS1 4579612 4579723
chr_2 g4741 g4741.t2 exon g4741.t2.exon2 4579794 4579870
chr_2 g4741 g4741.t2 cds g4741.t2.CDS2 4579794 4579870
chr_2 g4741 g4741.t2 exon g4741.t2.exon3 4579990 4581305
chr_2 g4741 g4741.t2 cds g4741.t2.CDS3 4579990 4581096
chr_2 g4741 g4741.t2 TSS g4741.t2 NA NA
chr_2 g4741 g4741.t2 TTS g4741.t2 NA NA

Sequences

>g4741.t2 Gene=g4741 Length=1937
GACTGTCTGCAGAGCTGTATTATGTTCGTGAAGGCTTAATCAATAAATATGCACTGACGT
TCACAGTGCCAGTTGGTGAGAATATTCGAGATATTGCATTTACGTGGCAAAGTTTAGCTG
GTCGACCATTGCCCTATAAAATCAATATAGCCACAACTGATCCCGTTGTGCTGCCACGTC
CACAACTCAATATCAGTCGAATAGGTGAAATGCCGCAGGATATCCAGACTTTTGCAATTG
AAATGCGTTGCTCAGGTGTAAGAGCAGCTGAAGTTGATGTCACAATATCCATTGAAGTGA
CACTCAATCGTGCAACAAATAATGTAACAGAATTAGTATTTACAAGAAGAAAGGTGTGCT
TACAAAGTGATGTAGTTGAAGACCATACAGACGATACAACATCACATACAAATATTGCAA
AACCACCAAATGCGATTATCACTTTAATCGTAGGTGGCATTCTTGCTATGATTGTCGTCG
CTATTTTAATATCAGTCGCATATTGTGCACGTGGACCATCAAAAAGGAAACCACATTTAT
CACAGCCTGTACGAACATCCAGTTTTCAACGTCTACAGACACATTCATCTTCCTTAGCAC
CTTCCATTTGTCCTACAAATGCTACATTACCACGAAGTAAATGTTCTGAACCAGAAGAAC
TTCATCGTCGTATTTCTGAAATTACCGTTCAACGATGTCGTGTTCGTTTATCGAGTCTGC
TTCAGGAAGGTACATTCGGTCGTGTCTATCGTGGAACATACAACGACACTCAGGAAGTTT
TGGTAAAAACTGTAGGACAGCAAGCAAATCAAACACAAGTTTCGTTGCTTCTACAGGAAG
GCATGAATCTTTATGGAGCTTGTCATGTTGGAATTTTATCTGTTTTTGGTGTCTCAATTG
AAGATCATACAGCTCCTTTCTTACTCTATGCTTCAGACAACAATACAAAGAATTTGAAAC
TTTTCTTACAAGAACCAATAGCAAGAACTCTCACAACTATTCAAATTGTCAAAATGTCAT
CTCAATTAGCTGCTGCAATTTGTCATTTGCATGCTCATGGAGTTCTACACAAAGATATTG
CTGCTAGAAATTGCGTAATTGATGATGATTTAACTGTAAAATTGACAGATAATTCTCTGT
CTCGAGATCTCTTTCCACAAGACTATCATTGTCTTGGTGATCGTGAAAATCGACCTGTCA
AATGGCTCTCGCTTGAGGCTCTCACTAAAAAGCAATTCAGTGAAGCATCTGATGCTTGGG
CATTTGGTGTTTTGATTTGGGAATTGTGCACGTTAGCTAAATCACCTTATAACGATATTG
ATGCCTTCGAGATCGAAAATTATTTACGTGACGGATATCGATTAGTACAGCCACTCAATT
GCCCTGATGAATTATTCACAATCATGGCTTATTGCTGGGCTGTTTCAATTCTAGAGCGTC
CAACTTTTCAACAGTTGCAGTTCTGTTTGCAAGATTTTTATAATCAACTCACACGTTATG
TATGAAATTACGATTATGAACTGAATATTTGAACTGAAAACTGCCAAATAACTCGTCAGG
CGAGCACTTGAATCAAAGATGAACTATAAAATGAACTTACGAAAAAAAATAATATTGGCA
ATTTGACATCTATTATTTATATATGAAGTAAAATATGTTTGAATTATTTTTCTTTTAACA
ATAATAATGATGATAAAAAAATCAACTATTTTATTTCCATTTCTGTGATATTAAATGTTA
TACTTTATAAACAAACCGACAGTGTAAAGGATTTGCTTTTTTGTAAAACGATAATAAATT
TGAAAGTAGTGTGAATGTGTTTTTGTTATAACATTTATGTAGTTTTCTAGTAATATGTTA
TACATTAAACAAGTGGAAGAATGAACAAAAAAGTGTCATTATAATTTAAGCCTAATAAAA
AAATCAATAATTCGAAA

>g4741.t2 Gene=g4741 Length=431
MPQDIQTFAIEMRCSGVRAAEVDVTISIEVTLNRATNNVTELVFTRRKVCLQSDVVEDHT
DDTTSHTNIAKPPNAIITLIVGGILAMIVVAILISVAYCARGPSKRKPHLSQPVRTSSFQ
RLQTHSSSLAPSICPTNATLPRSKCSEPEELHRRISEITVQRCRVRLSSLLQEGTFGRVY
RGTYNDTQEVLVKTVGQQANQTQVSLLLQEGMNLYGACHVGILSVFGVSIEDHTAPFLLY
ASDNNTKNLKLFLQEPIARTLTTIQIVKMSSQLAAAICHLHAHGVLHKDIAARNCVIDDD
LTVKLTDNSLSRDLFPQDYHCLGDRENRPVKWLSLEALTKKQFSEASDAWAFGVLIWELC
TLAKSPYNDIDAFEIENYLRDGYRLVQPLNCPDELFTIMAYCWAVSILERPTFQQLQFCL
QDFYNQLTRYV

Protein features from InterProScan

Transcript Database ID Name Start End E.value
10 g4741.t2 Gene3D G3DSA:3.30.200.20 Phosphorylase Kinase; domain 1 117 240 6.1E-14
11 g4741.t2 Gene3D G3DSA:1.10.510.10 Transferase(Phosphotransferase) domain 1 241 430 1.8E-41
3 g4741.t2 PANTHER PTHR24416:SF531 DERAILED 2, ISOFORM B 142 428 1.8E-87
4 g4741.t2 PANTHER PTHR24416 TYROSINE-PROTEIN KINASE RECEPTOR 142 428 1.8E-87
15 g4741.t2 PIRSF PIRSF000615 TyrPK_CSF1-R 12 104 27.0
16 g4741.t2 PIRSF PIRSF000615 TyrPK_CSF1-R 198 430 4.1E-36
6 g4741.t2 PRINTS PR00109 Tyrosine kinase catalytic domain signature 279 297 1.0E-20
5 g4741.t2 PRINTS PR00109 Tyrosine kinase catalytic domain signature 328 338 1.0E-20
8 g4741.t2 PRINTS PR00109 Tyrosine kinase catalytic domain signature 347 369 1.0E-20
7 g4741.t2 PRINTS PR00109 Tyrosine kinase catalytic domain signature 391 413 1.0E-20
2 g4741.t2 Pfam PF02019 WIF domain 2 50 1.1E-7
1 g4741.t2 Pfam PF07714 Protein tyrosine and serine/threonine kinase 167 418 2.0E-62
13 g4741.t2 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 1 74 -
14 g4741.t2 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 75 100 -
12 g4741.t2 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 101 431 -
18 g4741.t2 ProSitePatterns PS00109 Tyrosine protein kinases specific active-site signature. 285 297 -
19 g4741.t2 ProSiteProfiles PS50814 WIF domain profile. 1 50 19.498
20 g4741.t2 ProSiteProfiles PS50011 Protein kinase domain profile. 165 424 25.375
9 g4741.t2 SUPERFAMILY SSF56112 Protein kinase-like (PK-like) 157 421 1.52E-51
17 g4741.t2 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 76 98 -

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0005524 ATP binding MF
GO:0004672 protein kinase activity MF
GO:0006468 protein phosphorylation BP

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values