General information for g4752.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Multidrug resistance-associated protein 1.
Parent gene
- The parent gene g4752 is located on chr_2: 4709593..4710572 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g4752 | g4752.t1 | TTS | g4752.t1 | 4708688 | 4708688 |
| chr_2 | g4752 | g4752.t1 | isoform | g4752.t1 | 4709593 | 4710572 |
| chr_2 | g4752 | g4752.t1 | exon | g4752.t1.exon1 | 4709593 | 4709787 |
| chr_2 | g4752 | g4752.t1 | cds | g4752.t1.CDS1 | 4709593 | 4709787 |
| chr_2 | g4752 | g4752.t1 | exon | g4752.t1.exon2 | 4709855 | 4709953 |
| chr_2 | g4752 | g4752.t1 | cds | g4752.t1.CDS2 | 4709855 | 4709953 |
| chr_2 | g4752 | g4752.t1 | exon | g4752.t1.exon3 | 4710015 | 4710572 |
| chr_2 | g4752 | g4752.t1 | cds | g4752.t1.CDS3 | 4710015 | 4710572 |
| chr_2 | g4752 | g4752.t1 | TSS | g4752.t1 | NA | NA |
Sequences
>g4752.t1 Gene=g4752 Length=852
ATGTCATCGGAAGTTGAAACAAATATTGTAGCAGTTGAACGTATTAAAGAGTATGGTGAA
ACAAAACAAGAAGCAGCGTGGGAGAACAGTGTCGTTTTACCAACTAACTGGCCTGAAAAT
GGCAATATTGAGTTCCGTGACTTTCAAGTTCGTTACCGAGAAGGTCTCGATTTGGTACTT
CGTGGAATTAGTTTCAGAGTCAATGGTGGTGAGAAAGTCGGTATTGTTGGAAGAACTGGT
GCCGGTAAAAGTTCTCTCACACTTGCACTGTTCAGAATTATTGAAAGTGCTGGCGGTACC
ATCATCATTGATGGACAAGACATTTCAAAAATGGGTCTTCATGCACTTCGTTCGAGACTC
ACAATCATCCCTCAAGATCCCGTTTTATTCAGTGGCACATTGCGCATCAATTTAGATCCA
TTCAACAAATATTCAGATGAAGAAATTTGGCGTTCACTTGAACATGCTCATTTAAAACAT
TTCGTCAAGGGATTAGCAGCTGGAATCAATCACGAAATTACAGAAGGTGGTGAAAATTTG
TCAGTTGGTCAGCGACAGCTTGTTTGTCTTGCTCGTGCATTATTGAGAAAAACAAAGGTT
CTTGTGCTTGATGAAGCAACAGCTGCTGTCGACTTAGAAACTGATGATCTTATTCAAAAA
ACAATTCGAACAGAATTCAAAGAGTGCACTGTGCTTGTTATTGCACACAGATTAAATACT
ATTCTTGATTCTGATAAGGTTATCGTTTTGGATAAAGGACAAATCAAAGAATTTGCATCA
CCTGATGAGTTGTTACAAGATAAAAAGTCAGCGTTTTATAGTATGGCGAAAGATGCAAAT
CTCGTATCATAA
>g4752.t1 Gene=g4752 Length=283
MSSEVETNIVAVERIKEYGETKQEAAWENSVVLPTNWPENGNIEFRDFQVRYREGLDLVL
RGISFRVNGGEKVGIVGRTGAGKSSLTLALFRIIESAGGTIIIDGQDISKMGLHALRSRL
TIIPQDPVLFSGTLRINLDPFNKYSDEEIWRSLEHAHLKHFVKGLAAGINHEITEGGENL
SVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLVIAHRLNT
ILDSDKVIVLDKGQIKEFASPDELLQDKKSAFYSMAKDANLVS
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 6 | g4752.t1 | CDD | cd03244 | ABCC_MRP_domain2 | 41 | 261 | 1.95494E-146 |
| 5 | g4752.t1 | Gene3D | G3DSA:3.40.50.300 | - | 26 | 278 | 1.1E-90 |
| 2 | g4752.t1 | PANTHER | PTHR24223:SF241 | MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 | 1 | 282 | 8.8E-150 |
| 3 | g4752.t1 | PANTHER | PTHR24223 | ATP-BINDING CASSETTE SUB-FAMILY C | 1 | 282 | 8.8E-150 |
| 1 | g4752.t1 | Pfam | PF00005 | ABC transporter | 60 | 208 | 1.5E-31 |
| 7 | g4752.t1 | ProSitePatterns | PS00211 | ABC transporters family signature. | 180 | 194 | - |
| 9 | g4752.t1 | ProSiteProfiles | PS50893 | ATP-binding cassette, ABC transporter-type domain profile. | 43 | 277 | 19.535 |
| 8 | g4752.t1 | SMART | SM00382 | AAA_5 | 69 | 254 | 1.1E-14 |
| 4 | g4752.t1 | SUPERFAMILY | SSF52540 | P-loop containing nucleoside triphosphate hydrolases | 36 | 274 | 2.81E-74 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005524 | ATP binding | MF |
| GO:0016887 | ATP hydrolysis activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
