General information for g4802.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Dihydroorotate dehydrogenase (quinone), mitochondrial.
Parent gene
- The parent gene g4802 is located on chr_2: 5048013..5049356 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g4802 | g4802.t1 | TSS | g4802.t1 | 5047942 | 5047942 |
| chr_2 | g4802 | g4802.t1 | isoform | g4802.t1 | 5048013 | 5049356 |
| chr_2 | g4802 | g4802.t1 | exon | g4802.t1.exon1 | 5048013 | 5048246 |
| chr_2 | g4802 | g4802.t1 | cds | g4802.t1.CDS1 | 5048013 | 5048246 |
| chr_2 | g4802 | g4802.t1 | exon | g4802.t1.exon2 | 5048311 | 5048518 |
| chr_2 | g4802 | g4802.t1 | cds | g4802.t1.CDS2 | 5048311 | 5048518 |
| chr_2 | g4802 | g4802.t1 | exon | g4802.t1.exon3 | 5048581 | 5049356 |
| chr_2 | g4802 | g4802.t1 | cds | g4802.t1.CDS3 | 5048581 | 5049356 |
| chr_2 | g4802 | g4802.t1 | TTS | g4802.t1 | 5049441 | 5049441 |
Sequences
>g4802.t1 Gene=g4802 Length=1218
ATGGCAGCTAGTAAATTTGCACGTAAACTTAAATCTTTAATTACTGTGTCATGTTCATCA
GGAGTTCTATTAGGTTTATTATTATATAGAGAAAACGATGAGAAATTTTTTAGTAATTTT
TTGATGCCAACGTCCAGGTTTTTATTTTCTCAAAAAACTTGCAATAAATTAGCTTTATTT
TTTTGCAAGTGGAATTTATTGCCAAGGAATGACTATGTAGATTCATATAGACTGACAACA
AATATCTGTGGTATTGAATTAAATAACTGCATTGGTTTAGCAGCTGGATTTGATAGAAAT
GGTGATGCTATCAAAAATCTACATAAATTAGGATTCTCTTTCATAGAAATCGGCACAATT
ACGCCAGAACCAATAGAAGACGAATTAATAAAATATGTTGATGATAAGATAGCAAATAAT
CGCTATGATTCTATTAATAAGGGAATTGCTTACTCTGTACCAAAGATGCGAAATTTAAGA
AGAAAAGAAGAGTATACAGGCATAATTGGATTCAATATAGGCAAAAACTCAAATTCAAGT
TTTCTGAAAGACATTTCATTAGGCATTAAGGTTTATTCACCAGTCGCAAATTATATAACT
ATAAACATTGAAAGTGAAGCAAGCACTAATCCTTCTGAAATCTTGAAACAAAAAGAAAAT
CTTCGAGAAGTACTTACAGAAGTCAATAAAGCTAGACTGCTATTTGACATCGAAAAGCAA
CGACCGATTTTTCTTAAGCTCTCGCCTGAACTTACTCTCAATGAGCTCAAAGATATTATT
GAAGTTACGAAAGAAAAGAATTGCAAAGTACATGGTTTTATAATCTCCAACACGAGATTG
AAAGAGAAAAAGAGGAATGAAAATCCCGAAGGCAAATATAAAGCACAAGCAATTGAAAAT
GATGAGAACATTTCATTGAGAGAAAAATCGACACAAATGCTAAAAGACGTATACAAACTT
ACAAATGGCAAAAGTACTCTAATTGGTGTAGGTGAGATCACTTGTGGACAAGATGCATAT
GAAAAAATTTTGGCTGGCGCAAGTGCTGTTCAAATTTTCTCGAGTTTTATTGATCATGGT
CCACCAATAATTAATAAGATTAAACGTGAATTAAACGATTTACTCCAAGAAAATGGTTAT
GAAAATGTTAAAGAAGCTGTTGGGAAAGAAGTAAAATTAGAGAATAAAGGATGGTTTAAT
TTCTTTAGATTTAGATAA
>g4802.t1 Gene=g4802 Length=405
MAASKFARKLKSLITVSCSSGVLLGLLLYRENDEKFFSNFLMPTSRFLFSQKTCNKLALF
FCKWNLLPRNDYVDSYRLTTNICGIELNNCIGLAAGFDRNGDAIKNLHKLGFSFIEIGTI
TPEPIEDELIKYVDDKIANNRYDSINKGIAYSVPKMRNLRRKEEYTGIIGFNIGKNSNSS
FLKDISLGIKVYSPVANYITINIESEASTNPSEILKQKENLREVLTEVNKARLLFDIEKQ
RPIFLKLSPELTLNELKDIIEVTKEKNCKVHGFIISNTRLKEKKRNENPEGKYKAQAIEN
DENISLREKSTQMLKDVYKLTNGKSTLIGVGEITCGQDAYEKILAGASAVQIFSSFIDHG
PPIINKIKRELNDLLQENGYENVKEAVGKEVKLENKGWFNFFRFR
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 10 | g4802.t1 | CDD | cd04738 | DHOD_2_like | 46 | 371 | 2.4696E-91 |
| 5 | g4802.t1 | Gene3D | G3DSA:3.20.20.70 | Aldolase class I | 30 | 393 | 6.7E-88 |
| 2 | g4802.t1 | PANTHER | PTHR48109 | DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED | 21 | 389 | 3.9E-70 |
| 3 | g4802.t1 | PANTHER | PTHR48109:SF4 | DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL | 21 | 389 | 3.9E-70 |
| 1 | g4802.t1 | Pfam | PF01180 | Dihydroorotate dehydrogenase | 78 | 375 | 1.0E-48 |
| 7 | g4802.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1 | 11 | - |
| 9 | g4802.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 12 | 29 | - |
| 8 | g4802.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 30 | 405 | - |
| 4 | g4802.t1 | SUPERFAMILY | SSF51395 | FMN-linked oxidoreductases | 39 | 390 | 2.02E-50 |
| 6 | g4802.t1 | TIGRFAM | TIGR01036 | pyrD_sub2: dihydroorotate dehydrogenase (fumarate) | 65 | 390 | 1.2E-68 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors | MF |
| GO:0016020 | membrane | CC |
| GO:0004152 | dihydroorotate dehydrogenase activity | MF |
| GO:0006207 | ‘de novo’ pyrimidine nucleobase biosynthetic process | BP |
| GO:0003824 | catalytic activity | MF |
| GO:0055114 | NA | NA |
| GO:0005737 | cytoplasm | CC |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
