General information for g4919.t3
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Tyrosine-protein kinase hopscotch.
Parent gene
- The parent gene g4919 is located on chr_2: 5960936..5962852 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g4919 | g4919.t3 | isoform | g4919.t3 | 5960936 | 5962852 |
| chr_2 | g4919 | g4919.t3 | exon | g4919.t3.exon1 | 5960936 | 5961321 |
| chr_2 | g4919 | g4919.t3 | cds | g4919.t3.CDS1 | 5960998 | 5961321 |
| chr_2 | g4919 | g4919.t3 | exon | g4919.t3.exon2 | 5961385 | 5961702 |
| chr_2 | g4919 | g4919.t3 | cds | g4919.t3.CDS2 | 5961385 | 5961702 |
| chr_2 | g4919 | g4919.t3 | exon | g4919.t3.exon3 | 5962343 | 5962852 |
| chr_2 | g4919 | g4919.t3 | cds | g4919.t3.CDS3 | 5962343 | 5962852 |
| chr_2 | g4919 | g4919.t3 | TSS | g4919.t3 | NA | NA |
| chr_2 | g4919 | g4919.t3 | TTS | g4919.t3 | NA | NA |
Sequences
>g4919.t3 Gene=g4919 Length=1214
GTAGGAATTTGTCACGACATTATGAAAGTCCTATAAGTTCAAATCCTCGAAGTAATGGAA
CAATGCAAAGAATGAATGGAGGCATTCGCAATGGTCGTCCAAGTTCTTCAAATTCAATGT
TTTATAATAATGGAAGTTTAGTTTCTAATGAAACTGATCAAACATATATAAGTAGTTTAA
TGCCAGGAACACTGCACACGAATGCTTATATTGATGGTGGATCAAGTATAGACAATTCAA
GTCAAATATCATTACTTAATGGACATTCTATTGCCTCTAATGGTTCACATTCAACAACTA
ATGCATTTATTGAACATAATTTTGATGGTGAATGTATGGAGTTAGATGATAATAGAAAAT
TATCGTTTAGAGGATATATAGGAAGTGGCAATTTTGGAGTGGTTTATAAGGGAACTATTG
GACCATTAATATTTAATCCTATGGAAGATGAAGAAGAGGAAGTTGCCATTAAATGCTTTA
AACCAATTGATTCATTAAACCAAGCGAAAGATTTTCTGCGTGAAGTCAGAATGATGAAAG
CTTTAAATCATGAAAATATTGTTAAAATTTACGATTTTCATGAAGATTGGCTACTTATAA
TAATGGAGTATATGTCAGGTGGATCTCTTCAAGAATTTGTTGCAATACATCGACATGAAT
TAACAGTTGATGATATACTACAATTTGCTTTACATATTGCAAAAGGAATGCACTACTTAG
AACAAAATAAAATTGTTCATCGAGATTTGGCTGCGCGCAATGTGTTAGTGACGAGAAATA
GTTCACTTCTATTGTCTGATACTGTTTGTAAAATTGCCGATTTTGGTTTGGCTCAATTTA
CTAATCATTATGGATATTATGAGTCTACAAATAACAGAGATCTTCCTCTGCAATGGTATG
CTCCAGAAACAATTAGTTGCTTAAAATTTAGCTCAAAAAATGATGTATGGTCGTTTGGAA
TAACATTATGGGAAATGTTTTCATTTGGAGATACCCCAAGACTTGTTCCTAAATCAGATT
TTAAAGGTGAAGATTTGTTGCAGGCACTTGAAAAAGGTGAACGTCTTAAATGTCCTAAAC
ATTGTCCTCAAAATATTTATGAAGAACTGATGCGTGATGTATGTTGGAGTTATAATTCTG
ATAAAAGGCCAAATTTTGCTGGCATTATTGAAAAAATTCGAAATCTTTTAATTAGGAATG
GTGAATTAGTTTAA
>g4919.t3 Gene=g4919 Length=383
MQRMNGGIRNGRPSSSNSMFYNNGSLVSNETDQTYISSLMPGTLHTNAYIDGGSSIDNSS
QISLLNGHSIASNGSHSTTNAFIEHNFDGECMELDDNRKLSFRGYIGSGNFGVVYKGTIG
PLIFNPMEDEEEEVAIKCFKPIDSLNQAKDFLREVRMMKALNHENIVKIYDFHEDWLLII
MEYMSGGSLQEFVAIHRHELTVDDILQFALHIAKGMHYLEQNKIVHRDLAARNVLVTRNS
SLLLSDTVCKIADFGLAQFTNHYGYYESTNNRDLPLQWYAPETISCLKFSSKNDVWSFGI
TLWEMFSFGDTPRLVPKSDFKGEDLLQALEKGERLKCPKHCPQNIYEELMRDVCWSYNSD
KRPNFAGIIEKIRNLLIRNGELV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 9 | g4919.t3 | CDD | cd00192 | PTKc | 105 | 373 | 4.89821E-109 |
| 8 | g4919.t3 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 94 | 377 | 3.0E-75 |
| 2 | g4919.t3 | PANTHER | PTHR24418 | TYROSINE-PROTEIN KINASE | 51 | 373 | 1.9E-85 |
| 3 | g4919.t3 | PANTHER | PTHR24418:SF372 | TYROSINE-PROTEIN KINASE SHARK | 51 | 373 | 1.9E-85 |
| 4 | g4919.t3 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 181 | 194 | 3.3E-18 |
| 5 | g4919.t3 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 218 | 236 | 3.3E-18 |
| 6 | g4919.t3 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 293 | 315 | 3.3E-18 |
| 1 | g4919.t3 | Pfam | PF07714 | Protein tyrosine and serine/threonine kinase | 102 | 371 | 1.1E-80 |
| 11 | g4919.t3 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 106 | 137 | - |
| 10 | g4919.t3 | ProSitePatterns | PS00109 | Tyrosine protein kinases specific active-site signature. | 224 | 236 | - |
| 13 | g4919.t3 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 100 | 376 | 35.269 |
| 12 | g4919.t3 | SMART | SM00219 | tyrkin_6 | 100 | 372 | 6.8E-100 |
| 7 | g4919.t3 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 97 | 373 | 4.18E-68 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | MF |
| GO:0005524 | ATP binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
