General information for g6094.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as E3 ubiquitin-protein ligase Su(dx).
Parent gene
- The parent gene g6094 is located on chr_2: 14090824..14093246 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g6094 | g6094.t1 | TTS | g6094.t1 | 14087703 | 14087703 |
| chr_2 | g6094 | g6094.t1 | isoform | g6094.t1 | 14088596 | 14091621 |
| chr_2 | g6094 | g6094.t1 | exon | g6094.t1.exon1 | 14088596 | 14088681 |
| chr_2 | g6094 | g6094.t1 | cds | g6094.t1.CDS1 | 14088596 | 14088681 |
| chr_2 | g6094 | g6094.t1 | exon | g6094.t1.exon2 | 14088743 | 14088829 |
| chr_2 | g6094 | g6094.t1 | cds | g6094.t1.CDS2 | 14088743 | 14088829 |
| chr_2 | g6094 | g6094.t1 | exon | g6094.t1.exon3 | 14088902 | 14088998 |
| chr_2 | g6094 | g6094.t1 | cds | g6094.t1.CDS3 | 14088902 | 14088998 |
| chr_2 | g6094 | g6094.t1 | exon | g6094.t1.exon4 | 14089057 | 14089558 |
| chr_2 | g6094 | g6094.t1 | cds | g6094.t1.CDS4 | 14089057 | 14089558 |
| chr_2 | g6094 | g6094.t1 | exon | g6094.t1.exon5 | 14089634 | 14090171 |
| chr_2 | g6094 | g6094.t1 | cds | g6094.t1.CDS5 | 14089634 | 14090171 |
| chr_2 | g6094 | g6094.t1 | exon | g6094.t1.exon6 | 14090229 | 14091621 |
| chr_2 | g6094 | g6094.t1 | cds | g6094.t1.CDS6 | 14090229 | 14091621 |
| chr_2 | g6094 | g6094.t1 | TSS | g6094.t1 | NA | NA |
Sequences
>g6094.t1 Gene=g6094 Length=2703
ATGGCAGATTCAAATTCGTCAAATAGAACTCCTGCAATTAATCAAGGCTTTCATCAATTA
CAAATAACAATAGAGCATGCATCATTACGTAATTCATCGTTTTTAAAGCCAAATCCATAT
GTAGAACTTTCGGTCGATTCAAATCCTGCTCGCAAAACAGATTATCAAAAGACGACATAT
CTGCCTAAATGGAATGACACATTTACTGTGTTGGTCACACCAACATCAATTTTGCAATTC
CGAGTATATGACCATTCAAATTTTCGCAAAGATTCATTAATTGGTGAACAAACAGTGCAT
TTAGTTCAAATATTACAACATTATAATGGTCGTTGTGAGAATTTAGAATTGGCAATGGAC
CTTCTTTATGAATCAAAATCAGAAGGAAGACAAATAAAAAATGGTGAGCTAGTTGCAGTA
CTAAATGGTTTAAAAATCGATATGGTACAGAATAATGGTAATGATACTCAAGCTCGATCT
GTAACAGATCTCTCGTTTCAAAATGGTGCAATGTTGAGAAGTTCGATACTGAATGGCGGT
ATACGATCACGCATGAGGCTAAGAAGTAGTAATAACAATGGTTCAATACCGACACAACAA
CAACAAAATGGAAATGTGATACCTGCTGGTCAGAATGGTGTAAATAATAGTAGTGGATTA
GTTCAAAGTCCATCAACAGGTGCTGTAAGAAGATCTAGTGGAATGAATCAATGGGATCAA
CCACCATCACAACCGATGAATAACTATCAACGACTTACACCAGCCTTTTCAAATCCTCCT
ATAATGAATCCACAACAAGTTCCTCAACCTCCACCTCAATTGCAAGCTTCTCCTTCGCCA
AATTCTAATAACGCTGTAGTTGCACCGACAGCAGCAGCAGCAGGTGTTGTAGTACCTGCA
CAAAATGGTGAAGTAATGCGAGCTGCTGATGATGATGATGAAGAATTACCTTCAGGTTGG
GAAAGACGAACTGATCCATTTGGAAGAAGATATTATGTAGATCATAATACACGATCAACT
TATTGGGAAAAACCATCGCCTTTACCACCTGGTTGGGAGATTCGTAGAGACCCGAGAGGT
CGAGTTTATTATGTTGATCATAATACAAGAACAACAACATGGCAACGTCCAAATAGTGAG
CGATTAATGCATTTTCAACATTGGCAGGGTCAACGAGCACATGTAATGACACAGGGAAAC
CAAAGATTTCTCTATCCACAACATGCTCAGCAATCAAATACAACTCAAGCTCCAGTGCAA
GATGATGAAGATGGCCTTGGTCCATTGCCTGATGGCTGGGAAAAACGAGTGCAACCTGAT
AATCGAGTTTATTTTGTTAATCATAAAAATAGAACGACACAATGGGAGGATCCAAGAACA
CAGGGACAAGAAGTAAGTTTAATGGGAGCAGAAGGACCTTTACCAAGCGGATGGGAAATA
CGATACACAGCAACTGGTGAAAGATTTTTCGTTGATCATAATACGAGAAGAACAACATTT
GAAGATCCTCGACCAGGAGCTCAAAAAGGTGCAAAAGGAATGTATGGTGTACCTCGTGCA
TATGAAAGATCCTTCCGTTGGAAATTAAGTCAGTTCCGTTATTTATGTCAATCAAATGCT
TTACCGTCACATATAAAGATTACTCTCACGAGACAAACACTTTTCGAAGATTCTTATCAT
CAAATTATGCGATTACCTGCTTATGAACTACGGCGAAGGCTTTACATTATATTTCGAGGA
GAAGAAGGGCTCGATTATGGTGGTGTATCACGTGAATGGTTTTTCTTGTTATCACATGAA
GTTCTTAATCCTATGTACTGCCTATTCGAGTACGCTAACAAATCAAATTATTCGTTACAA
ATTAATCCAGCCTCTTATGTCAATCCAGATCATCTGCAATATTTTAAATTTATAGGACGT
TTCTTAGCTATGGCATTATATCACGGAAGATTTATTTATAGTGGTTTTACGATGCCCTTT
TACAAGCGAATGCTTAATAAAAAGTTGACGACCAAAGATATAGAATCGATAGATCCAGAA
TTTTATAATTCGCTTATATGGGTGCGAGATAATAATATTGATGAATGCGGCTTAGAGCTT
TGGTTTTCAGTAGATTTCGAGGTACTAGGACAAATCATACATCATGAGCTAAAAGCGAAT
GGTGATAAAGAGCGTGTAACTGAAGAAAATAAGGAAGAATATATAACATTAATGACTGAA
TGGAGAATGACAAGAGGTATTGAGGAACAAACTAAGACATTCCTCGATGGTTTTAATGAA
GTCGTGCCGTTGGAATGGTTGAAATATTTTGATGAAAGAGAATTAGAATTAATGCTTTGT
GGAATGCAAGAAATTGATGTCGATGATTGGCAACGGAATTCAATATATCGTCATTACAAT
AGAAATAGTAAACAAGTTGTGTGGTTCTGGCAGTTTGTTCGAGAGACTGATAACGAAAAG
CGTGCACGCTTACTTCAATTTGTCTGTGGTACTTGTCGAGTTCCCGTTGGAGGGTTTGCA
GAATTAATGGGTTCGAATGGGCCTCAAAGATTTTGTATTGAAAAAGTTGGAAAAGACACA
TGGCTGCCTCGTTCTCATACTTGTTTTAATCGATTAGACTTACCACCATATAAAAGTTAT
GATCAACTTGTTGAAAAATTAAATTACGCAATAGAAGAGACAGAAGGATTTGGCCAAGAA
TGA
>g6094.t1 Gene=g6094 Length=900
MADSNSSNRTPAINQGFHQLQITIEHASLRNSSFLKPNPYVELSVDSNPARKTDYQKTTY
LPKWNDTFTVLVTPTSILQFRVYDHSNFRKDSLIGEQTVHLVQILQHYNGRCENLELAMD
LLYESKSEGRQIKNGELVAVLNGLKIDMVQNNGNDTQARSVTDLSFQNGAMLRSSILNGG
IRSRMRLRSSNNNGSIPTQQQQNGNVIPAGQNGVNNSSGLVQSPSTGAVRRSSGMNQWDQ
PPSQPMNNYQRLTPAFSNPPIMNPQQVPQPPPQLQASPSPNSNNAVVAPTAAAAGVVVPA
QNGEVMRAADDDDEELPSGWERRTDPFGRRYYVDHNTRSTYWEKPSPLPPGWEIRRDPRG
RVYYVDHNTRTTTWQRPNSERLMHFQHWQGQRAHVMTQGNQRFLYPQHAQQSNTTQAPVQ
DDEDGLGPLPDGWEKRVQPDNRVYFVNHKNRTTQWEDPRTQGQEVSLMGAEGPLPSGWEI
RYTATGERFFVDHNTRRTTFEDPRPGAQKGAKGMYGVPRAYERSFRWKLSQFRYLCQSNA
LPSHIKITLTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHE
VLNPMYCLFEYANKSNYSLQINPASYVNPDHLQYFKFIGRFLAMALYHGRFIYSGFTMPF
YKRMLNKKLTTKDIESIDPEFYNSLIWVRDNNIDECGLELWFSVDFEVLGQIIHHELKAN
GDKERVTEENKEEYITLMTEWRMTRGIEEQTKTFLDGFNEVVPLEWLKYFDERELELMLC
GMQEIDVDDWQRNSIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVCGTCRVPVGGFA
ELMGSNGPQRFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYDQLVEKLNYAIEETEGFGQE
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 24 | g6094.t1 | CDD | cd04021 | C2_E3_ubiquitin_ligase | 17 | 142 | 4.49136E-51 |
| 25 | g6094.t1 | CDD | cd00201 | WW | 317 | 347 | 3.35148E-10 |
| 27 | g6094.t1 | CDD | cd00201 | WW | 349 | 377 | 7.1322E-12 |
| 26 | g6094.t1 | CDD | cd00201 | WW | 430 | 459 | 6.87965E-11 |
| 28 | g6094.t1 | CDD | cd00201 | WW | 475 | 505 | 8.12794E-9 |
| 29 | g6094.t1 | CDD | cd00078 | HECTc | 545 | 898 | 1.89595E-163 |
| 18 | g6094.t1 | Gene3D | G3DSA:2.60.40.150 | - | 16 | 156 | 1.8E-27 |
| 20 | g6094.t1 | Gene3D | G3DSA:2.20.70.10 | - | 308 | 346 | 2.2E-13 |
| 21 | g6094.t1 | Gene3D | G3DSA:2.20.70.10 | - | 347 | 383 | 6.7E-17 |
| 19 | g6094.t1 | Gene3D | G3DSA:2.20.70.10 | - | 396 | 464 | 1.1E-18 |
| 15 | g6094.t1 | Gene3D | G3DSA:3.90.1750.10 | Hect | 473 | 779 | 2.0E-136 |
| 16 | g6094.t1 | Gene3D | G3DSA:3.30.2160.10 | Hect | 668 | 746 | 2.0E-136 |
| 17 | g6094.t1 | Gene3D | G3DSA:3.30.2410.10 | Hect | 781 | 900 | 1.4E-47 |
| 39 | g6094.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 221 | 243 | - |
| 7 | g6094.t1 | PANTHER | PTHR11254:SF396 | NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2 | 5 | 900 | 0.0 |
| 8 | g6094.t1 | PANTHER | PTHR11254 | HECT DOMAIN UBIQUITIN-PROTEIN LIGASE | 5 | 900 | 0.0 |
| 22 | g6094.t1 | PIRSF | PIRSF001569 | E3_ub_ligase_SMURF1 | 3 | 347 | 1.5E-37 |
| 23 | g6094.t1 | PIRSF | PIRSF001569 | E3_ub_ligase_SMURF1 | 346 | 900 | 3.8E-263 |
| 1 | g6094.t1 | Pfam | PF00168 | C2 domain | 19 | 108 | 2.4E-15 |
| 2 | g6094.t1 | Pfam | PF00397 | WW domain | 316 | 345 | 4.3E-10 |
| 5 | g6094.t1 | Pfam | PF00397 | WW domain | 348 | 377 | 4.2E-13 |
| 3 | g6094.t1 | Pfam | PF00397 | WW domain | 429 | 458 | 3.6E-12 |
| 4 | g6094.t1 | Pfam | PF00397 | WW domain | 474 | 503 | 6.4E-8 |
| 6 | g6094.t1 | Pfam | PF00632 | HECT-domain (ubiquitin-transferase) | 596 | 898 | 9.5E-95 |
| 37 | g6094.t1 | ProSitePatterns | PS01159 | WW/rsp5/WWP domain signature. | 352 | 377 | - |
| 36 | g6094.t1 | ProSitePatterns | PS01159 | WW/rsp5/WWP domain signature. | 433 | 458 | - |
| 38 | g6094.t1 | ProSitePatterns | PS01159 | WW/rsp5/WWP domain signature. | 478 | 503 | - |
| 40 | g6094.t1 | ProSiteProfiles | PS50004 | C2 domain profile. | 19 | 98 | 11.996 |
| 42 | g6094.t1 | ProSiteProfiles | PS50020 | WW/rsp5/WWP domain profile. | 314 | 347 | 17.574 |
| 41 | g6094.t1 | ProSiteProfiles | PS50020 | WW/rsp5/WWP domain profile. | 346 | 379 | 18.776 |
| 43 | g6094.t1 | ProSiteProfiles | PS50020 | WW/rsp5/WWP domain profile. | 427 | 460 | 18.283 |
| 44 | g6094.t1 | ProSiteProfiles | PS50020 | WW/rsp5/WWP domain profile. | 472 | 505 | 15.447 |
| 45 | g6094.t1 | ProSiteProfiles | PS50237 | HECT domain profile. | 566 | 900 | 103.969 |
| 30 | g6094.t1 | SMART | SM00239 | C2_3c | 19 | 113 | 4.4E-9 |
| 32 | g6094.t1 | SMART | SM00456 | ww_5 | 315 | 347 | 8.8E-11 |
| 33 | g6094.t1 | SMART | SM00456 | ww_5 | 348 | 379 | 1.2E-11 |
| 35 | g6094.t1 | SMART | SM00456 | ww_5 | 428 | 460 | 3.3E-13 |
| 34 | g6094.t1 | SMART | SM00456 | ww_5 | 473 | 505 | 2.9E-11 |
| 31 | g6094.t1 | SMART | SM00119 | hect_3 | 564 | 900 | 8.9E-172 |
| 10 | g6094.t1 | SUPERFAMILY | SSF49562 | C2 domain (Calcium/lipid-binding domain, CaLB) | 16 | 130 | 2.53E-17 |
| 13 | g6094.t1 | SUPERFAMILY | SSF51045 | WW domain | 309 | 346 | 8.31E-12 |
| 11 | g6094.t1 | SUPERFAMILY | SSF51045 | WW domain | 346 | 379 | 4.3E-13 |
| 14 | g6094.t1 | SUPERFAMILY | SSF51045 | WW domain | 423 | 461 | 8.73E-14 |
| 12 | g6094.t1 | SUPERFAMILY | SSF51045 | WW domain | 468 | 505 | 3.86E-11 |
| 9 | g6094.t1 | SUPERFAMILY | SSF56204 | Hect, E3 ligase catalytic domain | 526 | 894 | 1.23E-131 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0061630 | ubiquitin protein ligase activity | MF |
| GO:0006511 | ubiquitin-dependent protein catabolic process | BP |
| GO:0005515 | protein binding | MF |
| GO:0004842 | ubiquitin-protein transferase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K05633 (NEDD4-like E3 ubiquitin-protein ligase WWP1)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
