General information for g6712.t3
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Potassium voltage-gated channel subfamily KQT member 5.
Parent gene
- The parent gene g6712 is located on chr_2: 18228170..18259288 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g6712 | g6712.t3 | isoform | g6712.t3 | 18228170 | 18259288 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon1 | 18228170 | 18228351 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS1 | 18228170 | 18228351 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon2 | 18231884 | 18232072 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS2 | 18231884 | 18232072 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon3 | 18232816 | 18232950 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS3 | 18232816 | 18232950 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon4 | 18234313 | 18234395 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS4 | 18234313 | 18234395 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon5 | 18234456 | 18234628 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS5 | 18234456 | 18234628 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon6 | 18236100 | 18236228 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS6 | 18236100 | 18236228 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon7 | 18236310 | 18236325 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS7 | 18236310 | 18236325 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon8 | 18236449 | 18236543 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS8 | 18236449 | 18236543 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon9 | 18237164 | 18237351 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS9 | 18237164 | 18237351 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon10 | 18245999 | 18246180 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS10 | 18245999 | 18246180 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon11 | 18246264 | 18246350 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS11 | 18246264 | 18246350 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon12 | 18248348 | 18248418 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS12 | 18248348 | 18248418 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon13 | 18249332 | 18249459 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS13 | 18249332 | 18249459 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon14 | 18253087 | 18253183 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS14 | 18253087 | 18253183 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon15 | 18253342 | 18253560 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS15 | 18253342 | 18253560 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon16 | 18253915 | 18254102 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS16 | 18253915 | 18254102 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon17 | 18254193 | 18254347 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS17 | 18254193 | 18254347 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon18 | 18258883 | 18259091 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS18 | 18258883 | 18259091 |
| chr_2 | g6712 | g6712.t3 | exon | g6712.t3.exon19 | 18259163 | 18259288 |
| chr_2 | g6712 | g6712.t3 | cds | g6712.t3.CDS19 | 18259163 | 18259288 |
| chr_2 | g6712 | g6712.t3 | TSS | g6712.t3 | NA | NA |
| chr_2 | g6712 | g6712.t3 | TTS | g6712.t3 | NA | NA |
Sequences
>g6712.t3 Gene=g6712 Length=2652
ATGAATAATATTGCTTCAAAAGTACCAAAAATTATAATAACAGAGGATGAAATTCAAAAA
GAAGAATTTGAAGAAACTTCACTACAAATTTATGCGACCAGCAGTGAATCGGAAAATGAA
GAAATTTCAAGAATTAATACATTTGAATCAAGAAACAAATTATTGAGACCAAATTCAATT
AGTGTTTGCAAATTATCCGACAAAAATAGAGTTGACAGACTTTCAAGGCCCCGAATGTCT
TTACTCGGGAAGCCCCTCAATTATAATCGAGGAGCCCGACGAGATGCTCGCTATCGGCGC
CTTCAATCACGTGTATACAACTTTCTTGAACGTCCTCGTGGGCTGCCAGCCGTTATCTAT
CATGTATTGGTATTTTTAATGGTTTTCACATGTTTGGCCTTGAGTGTCTTTTCGACAATC
GAAGAGTTCGAAAAGGAGGCACTGTCTTTGCTATTTGTTATGGAAATCATTGTCGTGATA
TGGTTTACTATAGAATTTGGACTCAGGATATGGGCATCAGGATGTCGTTCGAGATATCAA
GGAGGCATAGGCCGACTGAAATTTCTAAAAAGACCATTCTGTATTATAGACATAATAACA
ATAGCAGCATCAATTGTTGTAATCAGTATAGGAGCATCGAGTATGTTTGCAACAAGTGCT
CTTCGTGGTCTACGTTTTTTCCAAATCCTTCGAATGGTTCGCATGGATCGACGAGGTGGT
ACTTGGAAACTATTAGGAAGTGTGGTGTACGCCCATAGACAAGAACTCATAACAACTTTG
TATATTGGATTTCTAGGCCTTATATTCGCTTCATTTTTAGTTTATTTAATAGAAAAAGAC
ATTCAAAACACAAAATTTAAGAACTTCGCTCAAGCATTATGGTGGGGTGTTATTACTTTG
TGCACAGTTGGCTATGGGGATATGGTTCCGGAAACTTGGCAAGGAAAAATTGTTGCATCA
TTCTGTGCACTCCTCGGAATATCATTTTTCGCATTGCCCGCGGGTATTTTGGGCAGTGGA
TTTGCTTTAAAAGTACAACAGCAACAGAGACAGAAACATATGATCCGAAGAAGACAACCT
GCGGCTACATTGATACAATCATTATGGCGATGTTATGCAGCAGATGAACATTCCTTATCA
GAAGCAACATGGAAAATTCACCAAGTGCCATTGCCTTCTCCTCCTCCATCGCGAGCATCA
TCGAGCTTTAAGCACAACGCATCATTTGTGGCGAGACTTCCAACGATTCGACGGCATAAA
AGTCAATCACTTCACTCACCGGGTCAGAATCTGAAGCCAAGTGGGGGTAGTCAACGTGGT
CGAAATTGTCCAAGGACAATGAATGAAATCAATAATTCCGCTGAGAATCTTGATGTAACC
AACAATGGAAAGCCAATGAACGCGAGTCTATCAGAGGATTCAGTTGCAGAAACTGCTCTT
GCCAAAAAGAATTCCGACGATGAAGACGATGAACCCCGATGTGTTCAATTGACAAATCAA
CACAAGGGAGCAATTCGATTCATCAGAAAGATGAAATATTTCGTTGCACGAAGGAAATTC
AAAGAAGCGCTTAAACCTTATGATGTAAAAGATGTGATGGAACAATACGCATCAGGTCAT
GTTGATCTACTAGGACGCGTAAAAAATGTTCAAACTAGACTCGACCAGATATTAGGAAAG
CAGGGGTCCAAAGCAAAAGATGTATATGCGTCAAAAATTAGCCTGGCATCCCGTGTTGTA
AAAATTGAAAGACAGGTCGACGATGTTGAAACCAAATTAGATAATTTGATTGAATTGTAT
ATGCAAGACAGGAAGCGTTTACTTTCACTTCCGATTTGTCCCGATTCATCACATTCCAAT
AATCTTCCACCGCAACTGCCACCACCAAATGGTTCGGGTTCATCGATCGTAATTAGCAAT
AATATGGCAGTAAACAGTAGTACTAATGGTGCTAGTAGTAGTGGATCATTAAAGCCTAAG
CCAATTTTAGTTGATAAACAATCAAGCGAGCCTAATTCTCCAATCGCCAAATCTTTTGAT
GATCATCAACAAAAACATCAAAAACAGCATCAACTGCAACAGCAGCAACATCAAAATCGT
CCACCAATGCATCGTGGATTTTCAGATTTAGGCAATAGAATGAAGAAGCGAGTAACATTA
AGCGGTAATAGTGGTGACGTTGTGATAGTTGTACCATCAATGGACAACCTTCCTGAAGCT
GTTCGATCTGATACTCATCCACATCATCATATCTGCATCGATGCAGAAGGTGAAGTAGAA
GCACCAAATAGTCCTAAAACTATAACTGAAAGTTCAATGGTAATGTTTGAAGAAGAGGAA
GTTGAAGATGAATTAGACGAAGAAGAAGATCTTGATATTGGTACTGAAATAGATACCGAT
TCGCCACCTTGGGATTTCTTACATGTCGAGCCTGAGATCGATGATAATGATGATTCTAAT
GAAGATACTGCTCTTTTACGTTCAAAAGCTAAAAGAACGGAAATAGTAATAACACCAATT
AGTCCTGTAAGTTCATCAAATGATATTGTTCGTATGGGACATGATAGTCGTAGAAATGTG
ACCCGAGGAATGGATTTGCTTAAACCAGATATACAACAGTCATCATCTCAACGGATTTCC
GAAGAAATTTGA
>g6712.t3 Gene=g6712 Length=883
MNNIASKVPKIIITEDEIQKEEFEETSLQIYATSSESENEEISRINTFESRNKLLRPNSI
SVCKLSDKNRVDRLSRPRMSLLGKPLNYNRGARRDARYRRLQSRVYNFLERPRGLPAVIY
HVLVFLMVFTCLALSVFSTIEEFEKEALSLLFVMEIIVVIWFTIEFGLRIWASGCRSRYQ
GGIGRLKFLKRPFCIIDIITIAASIVVISIGASSMFATSALRGLRFFQILRMVRMDRRGG
TWKLLGSVVYAHRQELITTLYIGFLGLIFASFLVYLIEKDIQNTKFKNFAQALWWGVITL
CTVGYGDMVPETWQGKIVASFCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQP
AATLIQSLWRCYAADEHSLSEATWKIHQVPLPSPPPSRASSSFKHNASFVARLPTIRRHK
SQSLHSPGQNLKPSGGSQRGRNCPRTMNEINNSAENLDVTNNGKPMNASLSEDSVAETAL
AKKNSDDEDDEPRCVQLTNQHKGAIRFIRKMKYFVARRKFKEALKPYDVKDVMEQYASGH
VDLLGRVKNVQTRLDQILGKQGSKAKDVYASKISLASRVVKIERQVDDVETKLDNLIELY
MQDRKRLLSLPICPDSSHSNNLPPQLPPPNGSGSSIVISNNMAVNSSTNGASSSGSLKPK
PILVDKQSSEPNSPIAKSFDDHQQKHQKQHQLQQQQHQNRPPMHRGFSDLGNRMKKRVTL
SGNSGDVVIVVPSMDNLPEAVRSDTHPHHHICIDAEGEVEAPNSPKTITESSMVMFEEEE
VEDELDEEEDLDIGTEIDTDSPPWDFLHVEPEIDDNDDSNEDTALLRSKAKRTEIVITPI
SPVSSSNDIVRMGHDSRRNVTRGMDLLKPDIQQSSSQRISEEI
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 15 | g6712.t3 | Coils | Coil | Coil | 579 | 599 | - |
| 14 | g6712.t3 | Gene3D | G3DSA:1.10.287.70 | - | 117 | 344 | 6.5E-61 |
| 39 | g6712.t3 | MobiDBLite | mobidb-lite | consensus disorder prediction | 418 | 441 | - |
| 37 | g6712.t3 | MobiDBLite | mobidb-lite | consensus disorder prediction | 420 | 441 | - |
| 36 | g6712.t3 | MobiDBLite | mobidb-lite | consensus disorder prediction | 468 | 492 | - |
| 35 | g6712.t3 | MobiDBLite | mobidb-lite | consensus disorder prediction | 666 | 702 | - |
| 34 | g6712.t3 | MobiDBLite | mobidb-lite | consensus disorder prediction | 860 | 883 | - |
| 38 | g6712.t3 | MobiDBLite | mobidb-lite | consensus disorder prediction | 868 | 883 | - |
| 3 | g6712.t3 | PANTHER | PTHR11537:SF259 | KCNQ POTASSIUM CHANNEL, ISOFORM F | 67 | 670 | 5.4E-284 |
| 4 | g6712.t3 | PANTHER | PTHR11537 | VOLTAGE-GATED POTASSIUM CHANNEL | 67 | 670 | 5.4E-284 |
| 7 | g6712.t3 | PRINTS | PR00169 | Potassium channel signature | 153 | 176 | 2.2E-25 |
| 12 | g6712.t3 | PRINTS | PR01459 | KCNQ voltage-gated potassium channel family signature | 161 | 180 | 7.9E-22 |
| 11 | g6712.t3 | PRINTS | PR01459 | KCNQ voltage-gated potassium channel family signature | 181 | 200 | 7.9E-22 |
| 8 | g6712.t3 | PRINTS | PR00169 | Potassium channel signature | 226 | 252 | 2.2E-25 |
| 10 | g6712.t3 | PRINTS | PR01459 | KCNQ voltage-gated potassium channel family signature | 242 | 261 | 7.9E-22 |
| 9 | g6712.t3 | PRINTS | PR00169 | Potassium channel signature | 255 | 278 | 2.2E-25 |
| 6 | g6712.t3 | PRINTS | PR00169 | Potassium channel signature | 286 | 308 | 2.2E-25 |
| 5 | g6712.t3 | PRINTS | PR00169 | Potassium channel signature | 315 | 341 | 2.2E-25 |
| 2 | g6712.t3 | Pfam | PF00520 | Ion transport protein | 121 | 346 | 2.2E-30 |
| 1 | g6712.t3 | Pfam | PF03520 | KCNQ voltage-gated potassium channel | 495 | 604 | 1.0E-33 |
| 19 | g6712.t3 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1 | 117 | - |
| 27 | g6712.t3 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 118 | 138 | - |
| 21 | g6712.t3 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 139 | 149 | - |
| 25 | g6712.t3 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 150 | 172 | - |
| 18 | g6712.t3 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 173 | 192 | - |
| 26 | g6712.t3 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 193 | 217 | - |
| 22 | g6712.t3 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 218 | 255 | - |
| 28 | g6712.t3 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 256 | 277 | - |
| 17 | g6712.t3 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 278 | 288 | - |
| 24 | g6712.t3 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 289 | 306 | - |
| 20 | g6712.t3 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 307 | 317 | - |
| 23 | g6712.t3 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 318 | 343 | - |
| 16 | g6712.t3 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 344 | 883 | - |
| 13 | g6712.t3 | SUPERFAMILY | SSF81324 | Voltage-gated potassium channels | 113 | 342 | 9.99E-47 |
| 33 | g6712.t3 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 118 | 140 | - |
| 30 | g6712.t3 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 150 | 172 | - |
| 29 | g6712.t3 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 193 | 215 | - |
| 31 | g6712.t3 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 255 | 277 | - |
| 32 | g6712.t3 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 317 | 339 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0055085 | transmembrane transport | BP |
| GO:0006813 | potassium ion transport | BP |
| GO:0005249 | voltage-gated potassium channel activity | MF |
| GO:0005216 | ion channel activity | MF |
| GO:0006811 | ion transport | BP |
| GO:0008076 | voltage-gated potassium channel complex | CC |
KEGG
Orthology
- This transcript has been annotated with K04930 (potassium voltage-gated channel KQT-like subfamily member 5)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed