General information for g6789.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Tyrosine 3-monooxygenase.
Parent gene
- The parent gene g6789 is located on chr_2: 18653867..18660982 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g6789 | g6789.t1 | isoform | g6789.t1 | 18653867 | 18660982 |
| chr_2 | g6789 | g6789.t1 | exon | g6789.t1.exon1 | 18653867 | 18654268 |
| chr_2 | g6789 | g6789.t1 | cds | g6789.t1.CDS1 | 18653867 | 18654268 |
| chr_2 | g6789 | g6789.t1 | exon | g6789.t1.exon2 | 18654840 | 18654966 |
| chr_2 | g6789 | g6789.t1 | cds | g6789.t1.CDS2 | 18654840 | 18654966 |
| chr_2 | g6789 | g6789.t1 | exon | g6789.t1.exon3 | 18655710 | 18656529 |
| chr_2 | g6789 | g6789.t1 | cds | g6789.t1.CDS3 | 18655710 | 18656529 |
| chr_2 | g6789 | g6789.t1 | exon | g6789.t1.exon4 | 18657109 | 18657234 |
| chr_2 | g6789 | g6789.t1 | cds | g6789.t1.CDS4 | 18657109 | 18657234 |
| chr_2 | g6789 | g6789.t1 | exon | g6789.t1.exon5 | 18657368 | 18657460 |
| chr_2 | g6789 | g6789.t1 | cds | g6789.t1.CDS5 | 18657368 | 18657460 |
| chr_2 | g6789 | g6789.t1 | exon | g6789.t1.exon6 | 18658043 | 18658154 |
| chr_2 | g6789 | g6789.t1 | cds | g6789.t1.CDS6 | 18658043 | 18658154 |
| chr_2 | g6789 | g6789.t1 | exon | g6789.t1.exon7 | 18660905 | 18660982 |
| chr_2 | g6789 | g6789.t1 | cds | g6789.t1.CDS7 | 18660905 | 18660982 |
| chr_2 | g6789 | g6789.t1 | TSS | g6789.t1 | 18661289 | 18661289 |
| chr_2 | g6789 | g6789.t1 | TTS | g6789.t1 | NA | NA |
Sequences
>g6789.t1 Gene=g6789 Length=1758
ATGGCAGTTTCAGTAGCAGCTCATTCAGCACCAAAAAATCGCGAAATGTTTGCAATTAAA
AAATCTTACAGCATTGAGAATGGCTATCCATCACGTCGTCGTTCATTAGTCGATGACGCA
CGGTTCGAAAGTTCCGTCGTTAAACAGACAAAACAAGCTGTTTTGGAAGAAGCACGCCTT
AAGGCAAATGATGAAAAAGAACTCGACATTCCTAATGGCGAAAATAGTGAGAATGAAGAA
GAGGAGCAACCAGAAGTTGATGAACAGGAATACTATGTTGAAGTTGAGGATAATATTTAT
GTGAAACCGGTGGAAGGACCATCGTGCAATAATAAGCCATCAAATGATGATGATAAAAAA
GAAGAAAAGAAGGAAGAAGAAGAAAAAGAAAAAGTAGGCACGAGCGAAGACTCTGAGATG
ACCGAAGAGGAAATGATTTTGCAAAATGCTGCCGCTGTCTCAGAAGAGGCTGCAAATGAA
TTGATCAAGGCAGCTTTAGTTGTACGTTTACGTGATGGTATGGGCGCATTGGGTCGAATT
CTTAAAGCTGTTGAAACATTCAAAGGAACAGTCATTCACTTGGAATCACGCCAATCTCGC
GAAAAAAATATTCAATTTGATGTTTTGATAAAGATTGAAATGGCACGCTCAAGTTTATTG
CAATTATGCCGTTCACTTCGTCAATCAATGTCATTTGGTGGTATGACTGTACTAGCAGAA
AACAATGTCAATGTCAAGGCCCCATGGTTCCCAAAACACGCCTCTGAATTGGACGGTTGC
AATCATTTGATGACCAAATACGAACCTGATTTGGACATGAATCATCCAGGTTTTGCCGAT
AAAGAATATAGAGCACGCAGAAAGTTGATTGCTGAAGTTGCTTTTGCTTATAAATATGGT
GATCCTATTCCAGTCATTGAATACACTGAAACAGAAAACAAAACATGGGGATCCGTCTTT
AAAGTTGTTAAAGATTTAGTTCCAAAACATGCTTGCAAGGAATACATTCAAGTTTTCAAG
AAGCTCGAAGAAGAGAAAATTTTCACACCAGAACGCATTCCACAATTGCAAGAAATGAAT
GACTTTTTGCGCAAAAACACTGGCTTCACTCTTCGACCAGCTGCTGGTCTTTTAACATCA
CGTGACTTTCTCGCTTCATTAGCATTCCGAGTTTTCCAAAGTACACAATACGTTCGTCAT
GGCAATAGTCCTATGCATACACCAGAACCTGATTATATTCATGAGATGCTTGGACACATG
CCGCTACTTGGAGATGCATCATTTGCTCAATTCTCACAAGAAATTGGTCTCGCTTCATTA
GGCGCATCAGATGAGGAAATCGAAAAATTATCGACCGTCTACTGGTTTACAGTTGAATTT
GGTTTGTGCAAGGAAGAAAATCAGGTTAAAGCATATGGTGCTGGTTTGTTGTCAGCATAT
GGAGAATTGTTGCATGCAGTAAGTGACAAACCAGAACATCGTCCATTCGATCCAGAAAAG
ACAGCAGTCCAACCATATCAAGATCAAGAATATCAACCAATCTACTTTGTTGCCGAAAGC
TTCGAAGATGCGAAAGAAAAATTCCGTCGTTGGGTTTCAAGCATGTCACGCCCATTCGAA
GTTCGCTACAATCCACACACCGAACGCGTTGAAATCCTCGATTCAGTTGAAAAATTAGAA
GCACTTGTATCACAATTAAACACAGAAATGTTGCATTTGACGAATGCTATTGAAAAATTG
AGGAAACCACTTCTCTAA
>g6789.t1 Gene=g6789 Length=585
MAVSVAAHSAPKNREMFAIKKSYSIENGYPSRRRSLVDDARFESSVVKQTKQAVLEEARL
KANDEKELDIPNGENSENEEEEQPEVDEQEYYVEVEDNIYVKPVEGPSCNNKPSNDDDKK
EEKKEEEEKEKVGTSEDSEMTEEEMILQNAAAVSEEAANELIKAALVVRLRDGMGALGRI
LKAVETFKGTVIHLESRQSREKNIQFDVLIKIEMARSSLLQLCRSLRQSMSFGGMTVLAE
NNVNVKAPWFPKHASELDGCNHLMTKYEPDLDMNHPGFADKEYRARRKLIAEVAFAYKYG
DPIPVIEYTETENKTWGSVFKVVKDLVPKHACKEYIQVFKKLEEEKIFTPERIPQLQEMN
DFLRKNTGFTLRPAAGLLTSRDFLASLAFRVFQSTQYVRHGNSPMHTPEPDYIHEMLGHM
PLLGDASFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEENQVKAYGAGLLSAY
GELLHAVSDKPEHRPFDPEKTAVQPYQDQEYQPIYFVAESFEDAKEKFRRWVSSMSRPFE
VRYNPHTERVEILDSVEKLEALVSQLNTEMLHLTNAIEKLRKPLL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 15 | g6789.t1 | CDD | cd03345 | eu_TyrOH | 249 | 546 | 0.0 |
| 13 | g6789.t1 | Coils | Coil | Coil | 549 | 576 | - |
| 12 | g6789.t1 | Gene3D | G3DSA:1.10.800.10 | Phenylalanine Hydroxylase | 148 | 558 | 6.3E-170 |
| 16 | g6789.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 55 | 90 | - |
| 17 | g6789.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 55 | 73 | - |
| 19 | g6789.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 74 | 90 | - |
| 18 | g6789.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 102 | 143 | - |
| 20 | g6789.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 112 | 138 | - |
| 2 | g6789.t1 | PANTHER | PTHR11473:SF15 | TYROSINE 3-MONOOXYGENASE | 24 | 583 | 2.0E-233 |
| 3 | g6789.t1 | PANTHER | PTHR11473 | AROMATIC AMINO ACID HYDROXYLASE | 24 | 583 | 2.0E-233 |
| 14 | g6789.t1 | PIRSF | PIRSF000336 | TH | 14 | 584 | 1.8E-212 |
| 5 | g6789.t1 | PRINTS | PR00372 | Biopterin-dependent aromatic amino acid hydroxylase signature | 276 | 295 | 3.7E-67 |
| 7 | g6789.t1 | PRINTS | PR00372 | Biopterin-dependent aromatic amino acid hydroxylase signature | 367 | 389 | 3.7E-67 |
| 9 | g6789.t1 | PRINTS | PR00372 | Biopterin-dependent aromatic amino acid hydroxylase signature | 431 | 450 | 3.7E-67 |
| 8 | g6789.t1 | PRINTS | PR00372 | Biopterin-dependent aromatic amino acid hydroxylase signature | 471 | 489 | 3.7E-67 |
| 6 | g6789.t1 | PRINTS | PR00372 | Biopterin-dependent aromatic amino acid hydroxylase signature | 502 | 521 | 3.7E-67 |
| 4 | g6789.t1 | PRINTS | PR00372 | Biopterin-dependent aromatic amino acid hydroxylase signature | 537 | 555 | 3.7E-67 |
| 1 | g6789.t1 | Pfam | PF00351 | Biopterin-dependent aromatic amino acid hydroxylase | 248 | 577 | 3.9E-166 |
| 22 | g6789.t1 | ProSiteProfiles | PS51410 | Biopterin-dependent aromatic amino acid hydroxylase family profile. | 235 | 581 | 141.294 |
| 11 | g6789.t1 | SUPERFAMILY | SSF55021 | ACT-like | 158 | 253 | 2.52E-9 |
| 10 | g6789.t1 | SUPERFAMILY | SSF56534 | Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 247 | 580 | 2.35E-132 |
| 21 | g6789.t1 | TIGRFAM | TIGR01269 | Tyr_3_monoox: tyrosine 3-monooxygenase | 135 | 581 | 3.0E-221 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0042423 | catecholamine biosynthetic process | BP |
| GO:0009072 | aromatic amino acid family metabolic process | BP |
| GO:0005506 | iron ion binding | MF |
| GO:0004511 | tyrosine 3-monooxygenase activity | MF |
| GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | MF |
| GO:0004497 | monooxygenase activity | MF |
| GO:0055114 | NA | NA |
KEGG
Orthology
- This transcript has been annotated with K00501 (tyrosine 3-monooxygenase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
