Gene loci information

Transcript annotation

  • This transcript has been annotated as Tyrosine 3-monooxygenase.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_2 g6789 g6789.t2 isoform g6789.t2 18653867 18660982
chr_2 g6789 g6789.t2 exon g6789.t2.exon1 18653867 18654268
chr_2 g6789 g6789.t2 cds g6789.t2.CDS1 18653867 18654268
chr_2 g6789 g6789.t2 exon g6789.t2.exon2 18654840 18654966
chr_2 g6789 g6789.t2 cds g6789.t2.CDS2 18654840 18654966
chr_2 g6789 g6789.t2 exon g6789.t2.exon3 18655710 18656529
chr_2 g6789 g6789.t2 cds g6789.t2.CDS3 18655710 18656529
chr_2 g6789 g6789.t2 exon g6789.t2.exon4 18657368 18657460
chr_2 g6789 g6789.t2 cds g6789.t2.CDS4 18657368 18657460
chr_2 g6789 g6789.t2 exon g6789.t2.exon5 18658043 18658154
chr_2 g6789 g6789.t2 cds g6789.t2.CDS5 18658043 18658154
chr_2 g6789 g6789.t2 exon g6789.t2.exon6 18660905 18660982
chr_2 g6789 g6789.t2 cds g6789.t2.CDS6 18660905 18660982
chr_2 g6789 g6789.t2 TSS g6789.t2 18661289 18661289
chr_2 g6789 g6789.t2 TTS g6789.t2 NA NA

Sequences

>g6789.t2 Gene=g6789 Length=1632
ATGGCAGTTTCAGTAGCAGCTCATTCAGCACCAAAAAATCGCGAAATGTTTGCAATTAAA
AAATCTTACAGCATTGAGAATGGCTATCCATCACGTCGTCGTTCATTAGTCGATGACGCA
CGGTTCGAAAGTTCCGTCGTTAAACAGACAAAACAAGCTGTTTTGGAAGAAGCACGCCTT
AAGGCAAATGATGAAAAAGAACTCGACATTCCTAATGGCGAAAATAGTGAGAATGAAGAA
GAGGAGCAACCAGAAGTTGATGAACAGGAATACTATGTTGAAGACTCTGAGATGACCGAA
GAGGAAATGATTTTGCAAAATGCTGCCGCTGTCTCAGAAGAGGCTGCAAATGAATTGATC
AAGGCAGCTTTAGTTGTACGTTTACGTGATGGTATGGGCGCATTGGGTCGAATTCTTAAA
GCTGTTGAAACATTCAAAGGAACAGTCATTCACTTGGAATCACGCCAATCTCGCGAAAAA
AATATTCAATTTGATGTTTTGATAAAGATTGAAATGGCACGCTCAAGTTTATTGCAATTA
TGCCGTTCACTTCGTCAATCAATGTCATTTGGTGGTATGACTGTACTAGCAGAAAACAAT
GTCAATGTCAAGGCCCCATGGTTCCCAAAACACGCCTCTGAATTGGACGGTTGCAATCAT
TTGATGACCAAATACGAACCTGATTTGGACATGAATCATCCAGGTTTTGCCGATAAAGAA
TATAGAGCACGCAGAAAGTTGATTGCTGAAGTTGCTTTTGCTTATAAATATGGTGATCCT
ATTCCAGTCATTGAATACACTGAAACAGAAAACAAAACATGGGGATCCGTCTTTAAAGTT
GTTAAAGATTTAGTTCCAAAACATGCTTGCAAGGAATACATTCAAGTTTTCAAGAAGCTC
GAAGAAGAGAAAATTTTCACACCAGAACGCATTCCACAATTGCAAGAAATGAATGACTTT
TTGCGCAAAAACACTGGCTTCACTCTTCGACCAGCTGCTGGTCTTTTAACATCACGTGAC
TTTCTCGCTTCATTAGCATTCCGAGTTTTCCAAAGTACACAATACGTTCGTCATGGCAAT
AGTCCTATGCATACACCAGAACCTGATTATATTCATGAGATGCTTGGACACATGCCGCTA
CTTGGAGATGCATCATTTGCTCAATTCTCACAAGAAATTGGTCTCGCTTCATTAGGCGCA
TCAGATGAGGAAATCGAAAAATTATCGACCGTCTACTGGTTTACAGTTGAATTTGGTTTG
TGCAAGGAAGAAAATCAGGTTAAAGCATATGGTGCTGGTTTGTTGTCAGCATATGGAGAA
TTGTTGCATGCAGTAAGTGACAAACCAGAACATCGTCCATTCGATCCAGAAAAGACAGCA
GTCCAACCATATCAAGATCAAGAATATCAACCAATCTACTTTGTTGCCGAAAGCTTCGAA
GATGCGAAAGAAAAATTCCGTCGTTGGGTTTCAAGCATGTCACGCCCATTCGAAGTTCGC
TACAATCCACACACCGAACGCGTTGAAATCCTCGATTCAGTTGAAAAATTAGAAGCACTT
GTATCACAATTAAACACAGAAATGTTGCATTTGACGAATGCTATTGAAAAATTGAGGAAA
CCACTTCTCTAA

>g6789.t2 Gene=g6789 Length=543
MAVSVAAHSAPKNREMFAIKKSYSIENGYPSRRRSLVDDARFESSVVKQTKQAVLEEARL
KANDEKELDIPNGENSENEEEEQPEVDEQEYYVEDSEMTEEEMILQNAAAVSEEAANELI
KAALVVRLRDGMGALGRILKAVETFKGTVIHLESRQSREKNIQFDVLIKIEMARSSLLQL
CRSLRQSMSFGGMTVLAENNVNVKAPWFPKHASELDGCNHLMTKYEPDLDMNHPGFADKE
YRARRKLIAEVAFAYKYGDPIPVIEYTETENKTWGSVFKVVKDLVPKHACKEYIQVFKKL
EEEKIFTPERIPQLQEMNDFLRKNTGFTLRPAAGLLTSRDFLASLAFRVFQSTQYVRHGN
SPMHTPEPDYIHEMLGHMPLLGDASFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGL
CKEENQVKAYGAGLLSAYGELLHAVSDKPEHRPFDPEKTAVQPYQDQEYQPIYFVAESFE
DAKEKFRRWVSSMSRPFEVRYNPHTERVEILDSVEKLEALVSQLNTEMLHLTNAIEKLRK
PLL

Protein features from InterProScan

Transcript Database ID Name Start End E.value
15 g6789.t2 CDD cd03345 eu_TyrOH 207 504 0.0
13 g6789.t2 Coils Coil Coil 507 534 -
12 g6789.t2 Gene3D G3DSA:1.10.800.10 Phenylalanine Hydroxylase 106 516 5.0E-170
16 g6789.t2 MobiDBLite mobidb-lite consensus disorder prediction 58 73 -
18 g6789.t2 MobiDBLite mobidb-lite consensus disorder prediction 58 89 -
17 g6789.t2 MobiDBLite mobidb-lite consensus disorder prediction 74 89 -
2 g6789.t2 PANTHER PTHR11473:SF15 TYROSINE 3-MONOOXYGENASE 24 541 4.7E-234
3 g6789.t2 PANTHER PTHR11473 AROMATIC AMINO ACID HYDROXYLASE 24 541 4.7E-234
14 g6789.t2 PIRSF PIRSF000336 TH 14 542 1.6E-214
9 g6789.t2 PRINTS PR00372 Biopterin-dependent aromatic amino acid hydroxylase signature 234 253 2.7E-67
6 g6789.t2 PRINTS PR00372 Biopterin-dependent aromatic amino acid hydroxylase signature 325 347 2.7E-67
5 g6789.t2 PRINTS PR00372 Biopterin-dependent aromatic amino acid hydroxylase signature 389 408 2.7E-67
7 g6789.t2 PRINTS PR00372 Biopterin-dependent aromatic amino acid hydroxylase signature 429 447 2.7E-67
4 g6789.t2 PRINTS PR00372 Biopterin-dependent aromatic amino acid hydroxylase signature 460 479 2.7E-67
8 g6789.t2 PRINTS PR00372 Biopterin-dependent aromatic amino acid hydroxylase signature 495 513 2.7E-67
1 g6789.t2 Pfam PF00351 Biopterin-dependent aromatic amino acid hydroxylase 206 535 3.2E-166
20 g6789.t2 ProSiteProfiles PS51410 Biopterin-dependent aromatic amino acid hydroxylase family profile. 193 539 141.294
11 g6789.t2 SUPERFAMILY SSF55021 ACT-like 116 211 2.29E-9
10 g6789.t2 SUPERFAMILY SSF56534 Aromatic aminoacid monoxygenases, catalytic and oligomerization domains 205 538 1.96E-132
19 g6789.t2 TIGRFAM TIGR01269 Tyr_3_monoox: tyrosine 3-monooxygenase 94 539 3.4E-221

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0042423 catecholamine biosynthetic process BP
GO:0009072 aromatic amino acid family metabolic process BP
GO:0005506 iron ion binding MF
GO:0004511 tyrosine 3-monooxygenase activity MF
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen MF
GO:0004497 monooxygenase activity MF
GO:0055114 NA NA

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values