General information for g6847.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Angiotensin-converting enzyme.
Parent gene
- The parent gene g6847 is located on chr_2: 19138641..19140899 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g6847 | g6847.t1 | isoform | g6847.t1 | 19138641 | 19140899 |
| chr_2 | g6847 | g6847.t1 | exon | g6847.t1.exon1 | 19138641 | 19138669 |
| chr_2 | g6847 | g6847.t1 | cds | g6847.t1.CDS1 | 19138641 | 19138669 |
| chr_2 | g6847 | g6847.t1 | exon | g6847.t1.exon2 | 19138734 | 19138906 |
| chr_2 | g6847 | g6847.t1 | cds | g6847.t1.CDS2 | 19138734 | 19138906 |
| chr_2 | g6847 | g6847.t1 | exon | g6847.t1.exon3 | 19138981 | 19139543 |
| chr_2 | g6847 | g6847.t1 | cds | g6847.t1.CDS3 | 19138981 | 19139543 |
| chr_2 | g6847 | g6847.t1 | exon | g6847.t1.exon4 | 19139622 | 19139709 |
| chr_2 | g6847 | g6847.t1 | cds | g6847.t1.CDS4 | 19139622 | 19139709 |
| chr_2 | g6847 | g6847.t1 | exon | g6847.t1.exon5 | 19139767 | 19140078 |
| chr_2 | g6847 | g6847.t1 | cds | g6847.t1.CDS5 | 19139767 | 19140078 |
| chr_2 | g6847 | g6847.t1 | exon | g6847.t1.exon6 | 19140137 | 19140248 |
| chr_2 | g6847 | g6847.t1 | cds | g6847.t1.CDS6 | 19140137 | 19140248 |
| chr_2 | g6847 | g6847.t1 | exon | g6847.t1.exon7 | 19140311 | 19140899 |
| chr_2 | g6847 | g6847.t1 | cds | g6847.t1.CDS7 | 19140311 | 19140899 |
| chr_2 | g6847 | g6847.t1 | TSS | g6847.t1 | NA | NA |
| chr_2 | g6847 | g6847.t1 | TTS | g6847.t1 | NA | NA |
Sequences
>g6847.t1 Gene=g6847 Length=1866
ATGTTGAAGTTGTTAATATTAAAATTTGTGTTGTCGCTTGTTGTTTTGACAAATTGCCTC
AGTAATGATGAGCAAGCAGCCGAAAAACTTGTAGAAAAAATTTGTGATGAATTAAAGACA
AAAATGTATGAAACTAATGTGGCAAGTTGGAATCATGCAACAAATTTGACAAATGATAAT
GAAAAGAAAAAGGAAGATGCAGAACTAAAAATGGCCAAATATAATAAAAAAGCAGCTTTA
GAATTGCTTAAATTTGATTATAAAAATTTTAAAAATGAAACATTAAAAAGATTAATGTCT
AAAATGACAATGATTGGTGACAATATTCTCGATGAAAAAGATTTTCGTGAATTGTCTTCA
GCAATCTCTCAAATGCAATCAAATTTTGCAAAATTCAAAATAGGATGCTTCAAAAATAAA
AATGAATTGTTAGAATTTGAGCCAGACATTATTGAAATTCTTTTAAAAAGTCGAGATCCA
GATGAACTTGAATATTACTGGACTAATTTTTATAATCTTGCTGGCACGCCTTCAGTTAAA
AACTTTTACAAATATGTCGAATTGAGAAATAAAGCTGCAGTGAAAAATAAATTCAAAGAC
GGCTCTGAAATGTGGCTAAGCAATTATGAAGATGAAAATTTTGAGAAAAATATTGAAGAA
ATTTTGGAACAAATTAAGCCGTTTTACATGCAACTTCATGCTTTCGTTCGTCATAAATTA
CATGAACACTATGGTCCTGAACATGTTGATTTAAAGAAGCCAATTCCTATGCATCTACTT
GGTAATATGTGGGGTCAATTATGGGAAATTGATGACCTTATTGTGCCATATCAAAATGCT
TCAAAAATTGAATTTACTGAAGAATTAGTTAAACAAGGTTATACAGCAAAGAAAATGTTC
GAAACTGCAGAAGAATTTTTCAAATCCATCAATTTATCGCCAATGCCAGAGTTATTTTGG
AAAAATAGTGTAATTGAGAAGCCGAAAGATCGTGAAATTGTTTGTCATGCAAGTGCATGG
GATTTTACTATTAATGATGATGTCCGTATTAAAATGTGTACTAAAGTTACTATGGGAGAT
TTTGTTATTATTCATCATGAAATGGGTCACATTGAGTATCATCTTCAATATAAAAATCTT
CCTCTTCCATTTCGTAATGGTGCAAATGAAGGCTTTCATGAAGCAGTTGGTGATACAATT
GCATTATCAGTTTCGTCACCAAAACATCTTAATCGTATTGGTTTGTTGAAATCAAAAGGT
GATGAAGGACAGGAAAGCAACATCAATCAATTAATGTCAAATGCTCTACGCAAATTGGCC
TTGCTACCTTTTGCATATGTCATGGATAAATTCCGTTATGAAGTTTTTCGTGGAACAATT
GAACCCGAGAATGCAAATTGTCACTTTTGGAGACTTCGTGAAAAGCATGGCGGCATTGCT
CCCGCATCGGTGAGAGGCAATCATGATTTTGACATTACAGCAAAGTATCATGTCAGCGCT
GATGTCGAATACATGAGGTATTTTGTGGCAAACATTATTCAATTCCAATTTCATAAAGCG
GCATGCATCAAAGCGGGTGAATATGAGAGCGACTCTAAGAATCCGACTAAGAGTCTTAAT
AATTGCGATATTTATCAAAGCAAGGAGGCTGGCAATGCCTTAAAGGAGATGTTGTCATTA
GGAGCATCAAAGCATTGGAGTGATGTTCTTGAAACATTGACAGGAGAACGAAAATTGGAT
GCAAGTGCATTTTTAGAATATTTTCAACCATTACAAGATTGGCTAATCAAAACAAATGAA
GAACTTGGTGTAAATATTGGATGGGAATTATCGGATAAAATTGATTGCCCAAATTTGTAT
GAATGA
>g6847.t1 Gene=g6847 Length=621
MLKLLILKFVLSLVVLTNCLSNDEQAAEKLVEKICDELKTKMYETNVASWNHATNLTNDN
EKKKEDAELKMAKYNKKAALELLKFDYKNFKNETLKRLMSKMTMIGDNILDEKDFRELSS
AISQMQSNFAKFKIGCFKNKNELLEFEPDIIEILLKSRDPDELEYYWTNFYNLAGTPSVK
NFYKYVELRNKAAVKNKFKDGSEMWLSNYEDENFEKNIEEILEQIKPFYMQLHAFVRHKL
HEHYGPEHVDLKKPIPMHLLGNMWGQLWEIDDLIVPYQNASKIEFTEELVKQGYTAKKMF
ETAEEFFKSINLSPMPELFWKNSVIEKPKDREIVCHASAWDFTINDDVRIKMCTKVTMGD
FVIIHHEMGHIEYHLQYKNLPLPFRNGANEGFHEAVGDTIALSVSSPKHLNRIGLLKSKG
DEGQESNINQLMSNALRKLALLPFAYVMDKFRYEVFRGTIEPENANCHFWRLREKHGGIA
PASVRGNHDFDITAKYHVSADVEYMRYFVANIIQFQFHKAACIKAGEYESDSKNPTKSLN
NCDIYQSKEAGNALKEMLSLGASKHWSDVLETLTGERKLDASAFLEYFQPLQDWLIKTNE
ELGVNIGWELSDKIDCPNLYE
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 20 | g6847.t1 | CDD | cd06461 | M2_ACE | 30 | 599 | 0.0 |
| 14 | g6847.t1 | Coils | Coil | Coil | 57 | 77 | - |
| 2 | g6847.t1 | PANTHER | PTHR10514 | ANGIOTENSIN-CONVERTING ENZYME | 21 | 613 | 1.0E-224 |
| 7 | g6847.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 218 | 245 | 6.8E-78 |
| 8 | g6847.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 253 | 274 | 6.8E-78 |
| 10 | g6847.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 329 | 354 | 6.8E-78 |
| 3 | g6847.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 361 | 377 | 6.8E-78 |
| 6 | g6847.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 389 | 409 | 6.8E-78 |
| 4 | g6847.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 431 | 456 | 6.8E-78 |
| 5 | g6847.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 466 | 493 | 6.8E-78 |
| 9 | g6847.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 494 | 522 | 6.8E-78 |
| 1 | g6847.t1 | Pfam | PF01401 | Angiotensin-converting enzyme | 22 | 608 | 7.8E-218 |
| 16 | g6847.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 21 | - |
| 17 | g6847.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 3 | - |
| 18 | g6847.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 4 | 16 | - |
| 19 | g6847.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 17 | 21 | - |
| 15 | g6847.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 22 | 621 | - |
| 11 | g6847.t1 | SUPERFAMILY | SSF55486 | Metalloproteases (zincins), catalytic domain | 25 | 609 | 8.96E-198 |
| 13 | g6847.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 21 | - |
| 21 | g6847.t1 | SignalP_GRAM_NEGATIVE | SignalP-noTM | SignalP-noTM | 1 | 26 | - |
| 12 | g6847.t1 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM | 1 | 26 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0008241 | peptidyl-dipeptidase activity | MF |
| GO:0008237 | metallopeptidase activity | MF |
| GO:0006508 | proteolysis | BP |
KEGG
Orthology
- This transcript has been annotated with K01283 (peptidyl-dipeptidase A)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed