General information for g7122.t11
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Protein henna.
Parent gene
- The parent gene g7122 is located on chr_2: 21344827..21345609 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7122 | g7122.t11 | TTS | g7122.t11 | 21342968 | 21342968 |
| chr_2 | g7122 | g7122.t11 | isoform | g7122.t11 | 21343416 | 21345609 |
| chr_2 | g7122 | g7122.t11 | exon | g7122.t11.exon1 | 21343416 | 21343446 |
| chr_2 | g7122 | g7122.t11 | cds | g7122.t11.CDS1 | 21343416 | 21343446 |
| chr_2 | g7122 | g7122.t11 | exon | g7122.t11.exon2 | 21343500 | 21343652 |
| chr_2 | g7122 | g7122.t11 | cds | g7122.t11.CDS2 | 21343500 | 21343652 |
| chr_2 | g7122 | g7122.t11 | exon | g7122.t11.exon3 | 21343712 | 21344085 |
| chr_2 | g7122 | g7122.t11 | cds | g7122.t11.CDS3 | 21343712 | 21344085 |
| chr_2 | g7122 | g7122.t11 | exon | g7122.t11.exon4 | 21344164 | 21344469 |
| chr_2 | g7122 | g7122.t11 | cds | g7122.t11.CDS4 | 21344164 | 21344469 |
| chr_2 | g7122 | g7122.t11 | exon | g7122.t11.exon5 | 21344564 | 21344877 |
| chr_2 | g7122 | g7122.t11 | cds | g7122.t11.CDS5 | 21344564 | 21344877 |
| chr_2 | g7122 | g7122.t11 | exon | g7122.t11.exon6 | 21344950 | 21345139 |
| chr_2 | g7122 | g7122.t11 | cds | g7122.t11.CDS6 | 21344950 | 21345139 |
| chr_2 | g7122 | g7122.t11 | exon | g7122.t11.exon7 | 21345420 | 21345609 |
| chr_2 | g7122 | g7122.t11 | cds | g7122.t11.CDS7 | 21345420 | 21345458 |
| chr_2 | g7122 | g7122.t11 | TSS | g7122.t11 | 21345607 | 21345607 |
Sequences
>g7122.t11 Gene=g7122 Length=1558
GTCAGTCGAAATACAGTCGTGCAAGATTTAACTTCGATAGAGGTAGAAAATAAGAAATTT
CAAAAAGTCAGTTGAAAGTGAACAAGTGTTGTTCATCATTATAACATCTTATTATAGTGC
ATTTAATAATTGAAAATGTACGCAAAATCTAATGGAACAAATGGCACGAATCTTTCAGAA
GTTATCGGAACCAAAGTTGAAGGAAGGCGGATCGTACATTATGGAGTCACATTCCTCATC
AAGTTCTGGAAAAACAATTATAATATTTTCACCAACTGATCAAAGCAGTGCCGGTAGCTT
AGCAAAAGTGCTTAAAATTTTCGACGTATTTAGTGTCGATCTTACTCATATCGAATCACG
ATCATCACTGAGAGTTCCAGGCTATGAATTCATGGTCGAGTGCGACGTTCACAAAAATCC
CCATTTACACGATGCCCTGGAAATTCTCAAGGAAAAATGTTCATATTTTCAAGTAATATC
GCGTGCATATAATGAAGAAGAAACAAAAGAAGCAGCTGATGAAGTTGTTCCTTGGTTCCC
AAGACGTATTCGTGAATTAGATCGCTTCGCAAATCAAATTTTATCGTATGGTGCTGAGCT
CGATTCAGATCATCCTGGCTTCACAGACCCAGTCTATAGAGAACGTCGTAAATATTTTGC
CGATATAGCATATCACTATAAACACGGCCAACCGCTTCCACGAGTTGAATATACAGATGA
AGAAATAAAAACATGGGGTGTTGTTTTTAAAAATCTAACAAAGCTCTATCCAACACATGC
ATGTTATCAACACAACCATGTCTTCCAATTGTTGATAGAAAACTGCGGTTATCGCGAAGA
TAATATTCCACAATTAGAAGATGTTTCTAATTTCCTTAAAGATTGTACTGGTTTCACATT
GCGACCTGTTGCTGGTCTTCTCTCATCACGCGATTTTCTCGCTGGTCTTGCATTTCGAGT
TTTTCATTCTACACAATACATTCGTCATCCAAGTAAGCCGTTATACACGCCTGAACCTGA
TGTTGTTCATGAATTGATGGGACATGCTCCACTTTTTGCTGATCCAGCATTTGCACAATT
TTCACAAGAAATTGGTTTAGCATCACTTGGTGCACCTGATGATTATATTGAAAAATTAGC
AACATGCTTTTGGTTTACAGTTGAGTATGGCTTGTGTAGAGAAAATGGAAATCTCAAGGC
ATACGGTGCTGGTTTACTTTCGAGTTACGGTGAATTAGAATATTGTTTGAGTGACAAACC
ACAAATCAAAGATTTTGAACCTGAAGTAACTGGTTTACAAAAATATCCAATCACTGAGTA
TCAACCAATTTACTTTGTTGCTGATAGCTTCGACAATGCAAAGGATAAAATGATTAAATT
TGCTGATACGATTCCTCGTCCATTTGGAGTCCGCTACAACGCATACACTCAATCAATTGA
AGTTCTCGATACAAAACCACAGCTGAATAATTTGCTTTCGAATATCAATTTGGAGATGCA
TATATTGCAGAACGCATTACAAAAATTAATGATTGATCCAGAAGTGAAATGTCCATGA
>g7122.t11 Gene=g7122 Length=468
MEQMARIFQKLSEPKLKEGGSYIMESHSSSSSGKTIIIFSPTDQSSAGSLAKVLKIFDVF
SVDLTHIESRSSLRVPGYEFMVECDVHKNPHLHDALEILKEKCSYFQVISRAYNEEETKE
AADEVVPWFPRRIRELDRFANQILSYGAELDSDHPGFTDPVYRERRKYFADIAYHYKHGQ
PLPRVEYTDEEIKTWGVVFKNLTKLYPTHACYQHNHVFQLLIENCGYREDNIPQLEDVSN
FLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPLYTPEPDVVHELMGHAP
LFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFTVEYGLCRENGNLKAYGAGLLSSYG
ELEYCLSDKPQIKDFEPEVTGLQKYPITEYQPIYFVADSFDNAKDKMIKFADTIPRPFGV
RYNAYTQSIEVLDTKPQLNNLLSNINLEMHILQNALQKLMIDPEVKCP
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 14 | g7122.t11 | CDD | cd03347 | eu_PheOH | 127 | 432 | 0.0 |
| 12 | g7122.t11 | Coils | Coil | Coil | 442 | 462 | - |
| 11 | g7122.t11 | Gene3D | G3DSA:1.10.800.10 | Phenylalanine Hydroxylase | 20 | 437 | 3.8E-185 |
| 2 | g7122.t11 | PANTHER | PTHR11473 | AROMATIC AMINO ACID HYDROXYLASE | 26 | 459 | 6.7E-195 |
| 13 | g7122.t11 | PIRSF | PIRSF000336 | TH | 2 | 462 | 5.8E-206 |
| 8 | g7122.t11 | PRINTS | PR00372 | Biopterin-dependent aromatic amino acid hydroxylase signature | 155 | 174 | 1.8E-69 |
| 7 | g7122.t11 | PRINTS | PR00372 | Biopterin-dependent aromatic amino acid hydroxylase signature | 246 | 268 | 1.8E-69 |
| 6 | g7122.t11 | PRINTS | PR00372 | Biopterin-dependent aromatic amino acid hydroxylase signature | 310 | 329 | 1.8E-69 |
| 3 | g7122.t11 | PRINTS | PR00372 | Biopterin-dependent aromatic amino acid hydroxylase signature | 350 | 368 | 1.8E-69 |
| 5 | g7122.t11 | PRINTS | PR00372 | Biopterin-dependent aromatic amino acid hydroxylase signature | 381 | 400 | 1.8E-69 |
| 4 | g7122.t11 | PRINTS | PR00372 | Biopterin-dependent aromatic amino acid hydroxylase signature | 416 | 434 | 1.8E-69 |
| 1 | g7122.t11 | Pfam | PF00351 | Biopterin-dependent aromatic amino acid hydroxylase | 127 | 457 | 1.1E-175 |
| 17 | g7122.t11 | ProSiteProfiles | PS51671 | ACT domain profile. | 38 | 114 | 10.425 |
| 16 | g7122.t11 | ProSiteProfiles | PS51410 | Biopterin-dependent aromatic amino acid hydroxylase family profile. | 114 | 460 | 143.329 |
| 10 | g7122.t11 | SUPERFAMILY | SSF55021 | ACT-like | 27 | 132 | 5.95E-15 |
| 9 | g7122.t11 | SUPERFAMILY | SSF56534 | Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 126 | 459 | 3.27E-144 |
| 15 | g7122.t11 | TIGRFAM | TIGR01268 | Phe4hydrox_tetr: phenylalanine-4-hydroxylase | 21 | 459 | 5.6E-230 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0009072 | aromatic amino acid family metabolic process | BP |
| GO:0004505 | phenylalanine 4-monooxygenase activity | MF |
| GO:0005506 | iron ion binding | MF |
| GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | MF |
| GO:0004497 | monooxygenase activity | MF |
| GO:0055114 | NA | NA |
| GO:0006559 | L-phenylalanine catabolic process | BP |
KEGG
Orthology
- This transcript has been annotated with K00500 (phenylalanine-4-hydroxylase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
