General information for g7458.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Twitchin.
Parent gene
- The parent gene g7458 is located on chr_2: 23854685..23860102 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7458 | g7458.t1 | TSS | g7458.t1 | 23854139 | 23854139 |
| chr_2 | g7458 | g7458.t1 | isoform | g7458.t1 | 23854215 | 23860102 |
| chr_2 | g7458 | g7458.t1 | exon | g7458.t1.exon1 | 23854215 | 23854269 |
| chr_2 | g7458 | g7458.t1 | cds | g7458.t1.CDS1 | 23854215 | 23854269 |
| chr_2 | g7458 | g7458.t1 | exon | g7458.t1.exon2 | 23854682 | 23855196 |
| chr_2 | g7458 | g7458.t1 | cds | g7458.t1.CDS2 | 23854682 | 23855196 |
| chr_2 | g7458 | g7458.t1 | exon | g7458.t1.exon3 | 23855586 | 23855676 |
| chr_2 | g7458 | g7458.t1 | cds | g7458.t1.CDS3 | 23855586 | 23855676 |
| chr_2 | g7458 | g7458.t1 | exon | g7458.t1.exon4 | 23855733 | 23855807 |
| chr_2 | g7458 | g7458.t1 | cds | g7458.t1.CDS4 | 23855733 | 23855807 |
| chr_2 | g7458 | g7458.t1 | exon | g7458.t1.exon5 | 23856153 | 23856294 |
| chr_2 | g7458 | g7458.t1 | cds | g7458.t1.CDS5 | 23856153 | 23856294 |
| chr_2 | g7458 | g7458.t1 | exon | g7458.t1.exon6 | 23856363 | 23857966 |
| chr_2 | g7458 | g7458.t1 | cds | g7458.t1.CDS6 | 23856363 | 23857966 |
| chr_2 | g7458 | g7458.t1 | exon | g7458.t1.exon7 | 23858031 | 23860102 |
| chr_2 | g7458 | g7458.t1 | cds | g7458.t1.CDS7 | 23858031 | 23860102 |
| chr_2 | g7458 | g7458.t1 | TTS | g7458.t1 | 23860406 | 23860406 |
Sequences
>g7458.t1 Gene=g7458 Length=4554
ATGAAATATTTCACAGTTTTATTGTTTATTGGTGCTCAATTTATTGTGATAAACTCACTT
CCAACAAGATCAACTCTAAAAAAAGAACTTGATCAATTCAACGATGTGATAAATATTCAA
AGAATTTCAGAAATAATTCGTGAATATTGGGAAAATGATCCTTCAATACAAGCTCTCATT
AAATATTTAAAAAGTGACTCTTTCATGTCAGCATTGAACACATTTGTGAAATCAGAGGAA
GTCGATGATATTATTGAATGGATGCAATCGCATGGTGTTGACATTAAATTAGAAATTGAA
GAATTTAGTGAAGATATCAGCAGTATTCATCAATCATCATTGATTTTACAACAATTTTTC
TACGAGCAATTTTCATTGTCGACATTTGAGGAAGAAATCAGAAATGAAATCAAATATGAC
AAAATGAATGAACTGATTGACAATTTTTTACAAGATGGCAACGATTTTGCTCAACTATAT
TTAATTTTAAAAGTTAGTAAACCCTCTCTAGAGAATATTTTTATGAATGCAGAAATTCAA
AATGTGATTGGAGAATTGAAAAATTTAGGTAGAAAAAATGCTGCTAAAAATAGAAATTCT
TATCAATTTACGTTAGAACTTTTTAGTTTTGTAGGACATATTTTTATTGCGATTAGACTC
AGTGCTATGGGAAATCAGTCATCAAAAACACATAAAGAGAAATATAGCAGGAAAAATGTA
CACTGGAAATCCGCAGAACCACCACATGCACCTGGAAAGCCATATTTGCTACCAGGAGTT
CCAAGTGATGAACCAGATGTTGTCACAATAAAATGGCAAAAACCGACACTTGATGGCGGT
TCTTCAATTATTGGCTACATTGTTGAGCACAAGCGAACTGGCTCACCAAACTGGATTCGT
GCAAATCAACAGTTAATTCAATTAACAGAACTAACACTGACAGGTTTAGAGCCAGGTTGG
CGTTATCAATTTCGAATAATTGCTGAAAATGCTGTTGGTTGTTCACCACCAAGTGAAGCA
TCAGATCCATTAACTGTCACACTTCAACGTAATGCAGTTCAATCAACAGCACCAAAATTC
CTCGCTGAACTTGAAGATTTAAATGGAATTGAAAATGAAAAAGTTGAATTTAAAGTCAGA
GTGATTGGAACTCCTGCACCACAAATTTCATGGTTTAAAGATGGATTTGAAATTTTTAGT
AGTCGAAGAGCAAAAATTATAACAGAAAATGACACAAGCACTTTAATTTTCTATCAATCA
TCATTGACTGATGAAGGTGAAATTAAATGTACAGCAACAAATCGAGCTGGTTATGCATTT
ACAAAAGCTCGATTAATAATTGAAGCGCCGCCAAAAATTCGTTTGCCACGACAATATGAA
GACGGTTTAATAATTGAAGCTGAAGAAGTGATTAGATTAAAAGTTGGATTAGCTGGAAGA
CCAATACCATTAATTGAATGGAGTCATAATGGTGAAATTATTACAAGTGGTGGTCGTTAT
GAAATTTCAAGTAATGATAAAAATTCAACACTCAAAATTACCAATACATGTCGTACTGAT
CGTGGTGAATATCATTTAAAAGCTTCAAATTCACTTGGAGAAGATTCAACTTCATTTTTG
GTGACTGTCACAGCTCGTCCAACACAACCTGGTAAAATTGCAATAAAAATTCTTCCTGCT
AATACAGTTACACTTACCTGGGCTCCACCTGATGATGATGGCGGCTGTAAAATTGGAAAT
TACATTGTCGAATATTTTCGAATTGGTTGGAATGTTTGGTTGAAAGCTGCAACTTGTAGA
ACTCTTGCTGTAACTTTGAATGACTTGATTCCCGGCTCAGAATATAAATTTCGTGTGAAA
GCTGAAAATCCTTATGGTGTTAGTGATCCAAGTGAAGATTCAGATATTCTTTTTATTCCT
GATATTAAACGAGGCATAACAGATCCAACTAAAAGCAAATCACAACCCCAACTCGGTCTT
GATAGTGATTTTGCACCTAGAAGAAAACTTTCACCATCACCAGCACGATCAAAACTTACA
GAAAATATCGAAGAACAGCAGCAAAAGAAAGCTGCAACAATTCCACGAATAAAATTGAAT
ACAAAAATATTTGATGATGAAACAATTGAGCGTGATATGAATTATGGTGCATCTGATGAT
TTTTATAAATTTGGTGAAGTTCCATCGACATCACTTCATGAAAAATCAGAATTAGAACAT
CAAGTTAGACAACTAAAAAATGCCAAAAATAATGTAAAATTCAATGATAACTTGAAGACA
ACAAAAGTTGAAGACGAACCAATTTATGCGAATCTTCCAAAAGACAAACCACAAGAAACA
AGAGAAGATTTGCGTAAATATACAGGAAAACGCACATATTTAGATCTCTCAAAGACAGGT
GGTGATGCAGACAGAAGCATTCAAAATAGTAGTGAATTTATGCTTGTTCTTTATGCTGAT
AAAGACTCAAAAGGAGAACACAAAAATGACTCATTTGAGCTTGATGATTATTTTGAACTA
CCAAGACCATTATCACAATCAGCACCAGAACTTAATGCAATTGTTCCTGAAGGTCCAATT
TTACGTACAGCTGTAAGTTCAACCGAATTACTTTATGAACGTGCAATGGCAAGATTTTAT
AAAGCAGTTGAATACGAACAAACTGAAACAGCAAGAAAAAGAAGCATAAGTGTTGATCAA
GAAGCAAGACGAAGAAGTTTTAGTGTTGATCAAGAAGGAAAAAAAGTTGATGCACAAGAA
TCTGCATTGACACGTTTAAGAATAAATTCATTACCTGAAAGTGAGAAAATGAGTGTTCTA
AGACGAAGATTGTCAGGTGAAGTGCCAAATTTGCATATAAATATTCCCAAGAGATTAAGT
TTTAGTAAAGATGAAGAATCAGATGAAACTGATGCGACATATTTGAATACATTAAGAAAT
GAAGAACCTTATAGTGATGAACGATCTCCATCACCCTATATGTTAGCAAAGGAAAAAAAT
GAAGAACAAAAATTCAGTGATGATTATACAGATAGTACGGAATCATCAGATGATGAAGAA
GCTTCACCAAGACGTTCTCGATATCGTACTACTGAAAAAGATACTTACCATGCACGAATG
CTGTCACCATATAGACAACCACAGAAAGGTGAAGCTGCTGAAGTTCTAACTAAGCTTAAA
TCGCCAATTCCAGACCCAAATTTTGTTCCCAAACCAATTTTAAAACGACCAGCAAGTGCT
GATGGACGTAAACCTACAACACCAATCACACCACAACTGATTGTTACCAGTAGACGATCT
TTGTCACCATCGCCACCAATTAATCGAATTCATCGCAAGAGTGTCGAAATTGATACAACT
CCTGTGATTATTCAAGACTTAATTGATGATGTAAAAACAGAAATAGTTCCAGAAGTGCCA
AGAATTAAAGTTGAAGAACCAATAATTAAACAGCCATCACCTCCTAAGCCAGAACCAGAA
CCTGAAGAAGAAGAATTTAAACCCGATCCCGAAGTTATTAAACGAAATGAACAGACAAAA
CGAAAAATGCTCGAACGAAGACAAAGCTCAATTGAGGAGAATAAAGTGATGGCTGATTTT
TATGGTGACATAATTAAAACTCATTCTTTACCAACGAAACCAAAAATTCCTATTTATATG
GATCCAGAAGCACTCAAAAAGCTTGAAGCAGAAGAAGAACAACAACATGATTCTGGTGTG
ATTTCATCAGCAGAAATTTCACCTCAATCAAGCATAAGTAAACCTGTGCAGCAGCAACAA
AATCGAAGTCCATCACCATTTAGTAGAAGATCGTCTGATGTTGCTAAAATTTCACGACCA
TTCTCACCACCACCAAAGAATGAAGAAATTATAAAATCACGAAGAGCATCAGACAGTATG
AAAATTCAGAATGCGATAGGAAAGGAAAATTTCTCAAATCTTCCACTAAAAGACACAATT
GAAACTTTCAAATCAAATTATAATCGATTAGAATTAAATAAATCGCCTTCACCTCATAAT
TTCAATACAAGTGAAGCAAGTTCAACAGATGAGCTACAAACACGTGGTAGATTAATTGAA
AAATCACCAAAAGTAACTGGAACACTTCCAAAAAGAAGAAAAGCATCAAAATCACGTAGC
AGAGACAGCTCAATGATCCGAACACCTATTGAACTCAACTCGCAACCAACTCGACGCATG
AAGTCGTCATCTCGCACAAGAAATCGCAGTGAATCAAAATCACCAACAGCAATGAATAGA
AAAATTATTATAAATCGTGTGGCACCTCAAAATACGACACCAAAGTATGAACCTTCATCA
CCTTCACCACCACTTTCATCACGCACAGCAACACCAAGTGAACTGCAAGAAGAAGTTACA
TTGAAAGTTAAAAGCAACATGACATACGCCACTGATGTTTCAATCCTTGCATTTGCAACT
TATCTTTACTTTTTCAAAAGTGCTTTACTTGCACTTCCTATTTTAATCCTTCTAATCTAT
CGACAAATTGCAAACAAAATTCCTGATTGGTTAAAAAAGAAGAAAAAAAGTTAA
>g7458.t1 Gene=g7458 Length=1517
MKYFTVLLFIGAQFIVINSLPTRSTLKKELDQFNDVINIQRISEIIREYWENDPSIQALI
KYLKSDSFMSALNTFVKSEEVDDIIEWMQSHGVDIKLEIEEFSEDISSIHQSSLILQQFF
YEQFSLSTFEEEIRNEIKYDKMNELIDNFLQDGNDFAQLYLILKVSKPSLENIFMNAEIQ
NVIGELKNLGRKNAAKNRNSYQFTLELFSFVGHIFIAIRLSAMGNQSSKTHKEKYSRKNV
HWKSAEPPHAPGKPYLLPGVPSDEPDVVTIKWQKPTLDGGSSIIGYIVEHKRTGSPNWIR
ANQQLIQLTELTLTGLEPGWRYQFRIIAENAVGCSPPSEASDPLTVTLQRNAVQSTAPKF
LAELEDLNGIENEKVEFKVRVIGTPAPQISWFKDGFEIFSSRRAKIITENDTSTLIFYQS
SLTDEGEIKCTATNRAGYAFTKARLIIEAPPKIRLPRQYEDGLIIEAEEVIRLKVGLAGR
PIPLIEWSHNGEIITSGGRYEISSNDKNSTLKITNTCRTDRGEYHLKASNSLGEDSTSFL
VTVTARPTQPGKIAIKILPANTVTLTWAPPDDDGGCKIGNYIVEYFRIGWNVWLKAATCR
TLAVTLNDLIPGSEYKFRVKAENPYGVSDPSEDSDILFIPDIKRGITDPTKSKSQPQLGL
DSDFAPRRKLSPSPARSKLTENIEEQQQKKAATIPRIKLNTKIFDDETIERDMNYGASDD
FYKFGEVPSTSLHEKSELEHQVRQLKNAKNNVKFNDNLKTTKVEDEPIYANLPKDKPQET
REDLRKYTGKRTYLDLSKTGGDADRSIQNSSEFMLVLYADKDSKGEHKNDSFELDDYFEL
PRPLSQSAPELNAIVPEGPILRTAVSSTELLYERAMARFYKAVEYEQTETARKRSISVDQ
EARRRSFSVDQEGKKVDAQESALTRLRINSLPESEKMSVLRRRLSGEVPNLHINIPKRLS
FSKDEESDETDATYLNTLRNEEPYSDERSPSPYMLAKEKNEEQKFSDDYTDSTESSDDEE
ASPRRSRYRTTEKDTYHARMLSPYRQPQKGEAAEVLTKLKSPIPDPNFVPKPILKRPASA
DGRKPTTPITPQLIVTSRRSLSPSPPINRIHRKSVEIDTTPVIIQDLIDDVKTEIVPEVP
RIKVEEPIIKQPSPPKPEPEPEEEEFKPDPEVIKRNEQTKRKMLERRQSSIEENKVMADF
YGDIIKTHSLPTKPKIPIYMDPEALKKLEAEEEQQHDSGVISSAEISPQSSISKPVQQQQ
NRSPSPFSRRSSDVAKISRPFSPPPKNEEIIKSRRASDSMKIQNAIGKENFSNLPLKDTI
ETFKSNYNRLELNKSPSPHNFNTSEASSTDELQTRGRLIEKSPKVTGTLPKRRKASKSRS
RDSSMIRTPIELNSQPTRRMKSSSRTRNRSESKSPTAMNRKIIINRVAPQNTTPKYEPSS
PSPPLSSRTATPSELQEEVTLKVKSNMTYATDVSILAFATYLYFFKSALLALPILILLIY
RQIANKIPDWLKKKKKS
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 34 | g7458.t1 | CDD | cd00063 | FN3 | 258 | 345 | 3.65394E-19 |
| 33 | g7458.t1 | CDD | cd00096 | Ig | 375 | 444 | 3.10076E-14 |
| 35 | g7458.t1 | CDD | cd00063 | FN3 | 547 | 636 | 1.81337E-19 |
| 25 | g7458.t1 | Coils | Coil | Coil | 735 | 755 | - |
| 24 | g7458.t1 | Coils | Coil | Coil | 1174 | 1194 | - |
| 20 | g7458.t1 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins | 239 | 349 | 8.1E-26 |
| 23 | g7458.t1 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins | 351 | 459 | 3.1E-21 |
| 22 | g7458.t1 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins | 460 | 550 | 4.4E-19 |
| 21 | g7458.t1 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins | 551 | 655 | 7.8E-21 |
| 55 | g7458.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 648 | 691 | - |
| 47 | g7458.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 675 | 689 | - |
| 53 | g7458.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 890 | 916 | - |
| 46 | g7458.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 962 | 1049 | - |
| 52 | g7458.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 981 | 1039 | - |
| 51 | g7458.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1146 | 1193 | - |
| 50 | g7458.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1156 | 1193 | - |
| 44 | g7458.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1229 | 1298 | - |
| 45 | g7458.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1239 | 1272 | - |
| 49 | g7458.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1333 | 1353 | - |
| 54 | g7458.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1333 | 1453 | - |
| 43 | g7458.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1382 | 1401 | - |
| 48 | g7458.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1409 | 1435 | - |
| 6 | g7458.t1 | PANTHER | PTHR13817:SF10 | IMMUNOGLOBULIN SUPERFAMILY MEMBER 22 | 267 | 345 | 5.3E-72 |
| 9 | g7458.t1 | PANTHER | PTHR13817 | TITIN | 267 | 345 | 5.3E-72 |
| 7 | g7458.t1 | PANTHER | PTHR13817:SF10 | IMMUNOGLOBULIN SUPERFAMILY MEMBER 22 | 352 | 452 | 5.3E-72 |
| 10 | g7458.t1 | PANTHER | PTHR13817 | TITIN | 352 | 452 | 5.3E-72 |
| 8 | g7458.t1 | PANTHER | PTHR13817:SF10 | IMMUNOGLOBULIN SUPERFAMILY MEMBER 22 | 461 | 756 | 5.3E-72 |
| 11 | g7458.t1 | PANTHER | PTHR13817 | TITIN | 461 | 756 | 5.3E-72 |
| 15 | g7458.t1 | PRINTS | PR00014 | Fibronectin type III repeat signature | 561 | 570 | 2.1E-6 |
| 12 | g7458.t1 | PRINTS | PR00014 | Fibronectin type III repeat signature | 575 | 585 | 2.1E-6 |
| 13 | g7458.t1 | PRINTS | PR00014 | Fibronectin type III repeat signature | 597 | 615 | 2.1E-6 |
| 14 | g7458.t1 | PRINTS | PR00014 | Fibronectin type III repeat signature | 615 | 629 | 2.1E-6 |
| 1 | g7458.t1 | Pfam | PF06757 | Insect allergen related repeat, nitrile-specifier detoxification | 25 | 190 | 2.8E-22 |
| 4 | g7458.t1 | Pfam | PF00041 | Fibronectin type III domain | 264 | 338 | 9.5E-13 |
| 3 | g7458.t1 | Pfam | PF07679 | Immunoglobulin I-set domain | 358 | 447 | 1.2E-17 |
| 2 | g7458.t1 | Pfam | PF07679 | Immunoglobulin I-set domain | 465 | 543 | 6.7E-14 |
| 5 | g7458.t1 | Pfam | PF00041 | Fibronectin type III domain | 559 | 631 | 7.1E-10 |
| 28 | g7458.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 19 | - |
| 29 | g7458.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 3 | - |
| 30 | g7458.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 4 | 15 | - |
| 32 | g7458.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 16 | 19 | - |
| 27 | g7458.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 20 | 1474 | - |
| 31 | g7458.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 1475 | 1500 | - |
| 26 | g7458.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1501 | 1517 | - |
| 57 | g7458.t1 | ProSiteProfiles | PS50853 | Fibronectin type-III domain profile. | 250 | 350 | 21.318 |
| 59 | g7458.t1 | ProSiteProfiles | PS50835 | Ig-like domain profile. | 358 | 446 | 9.5 |
| 58 | g7458.t1 | ProSiteProfiles | PS50835 | Ig-like domain profile. | 451 | 544 | 7.268 |
| 56 | g7458.t1 | ProSiteProfiles | PS50853 | Fibronectin type-III domain profile. | 549 | 641 | 18.809 |
| 40 | g7458.t1 | SMART | SM00060 | FN3_2 | 251 | 335 | 2.3E-9 |
| 38 | g7458.t1 | SMART | SM00409 | IG_3c | 364 | 448 | 9.5E-4 |
| 41 | g7458.t1 | SMART | SM00408 | igc2_5 | 370 | 437 | 8.0E-4 |
| 37 | g7458.t1 | SMART | SM00409 | IG_3c | 460 | 544 | 0.088 |
| 42 | g7458.t1 | SMART | SM00408 | igc2_5 | 466 | 533 | 0.0069 |
| 39 | g7458.t1 | SMART | SM00060 | FN3_2 | 547 | 628 | 3.5E-13 |
| 16 | g7458.t1 | SUPERFAMILY | SSF49265 | Fibronectin type III | 247 | 637 | 7.86E-39 |
| 17 | g7458.t1 | SUPERFAMILY | SSF48726 | Immunoglobulin | 358 | 453 | 1.8E-21 |
| 18 | g7458.t1 | SUPERFAMILY | SSF48726 | Immunoglobulin | 463 | 550 | 5.77E-19 |
| 19 | g7458.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 19 | - |
| 36 | g7458.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 1477 | 1499 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005515 | protein binding | MF |
KEGG
Orthology
- This transcript has been annotated with K12567 (titin)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed