General information for g7472.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Activin receptor type-1.
Parent gene
- The parent gene g7472 is located on chr_2: 23909334..23911249 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7472 | g7472.t2 | TTS | g7472.t2 | 23908268 | 23908268 |
| chr_2 | g7472 | g7472.t2 | isoform | g7472.t2 | 23908725 | 23910908 |
| chr_2 | g7472 | g7472.t2 | exon | g7472.t2.exon1 | 23908725 | 23909103 |
| chr_2 | g7472 | g7472.t2 | cds | g7472.t2.CDS1 | 23908725 | 23909103 |
| chr_2 | g7472 | g7472.t2 | exon | g7472.t2.exon2 | 23909158 | 23909260 |
| chr_2 | g7472 | g7472.t2 | cds | g7472.t2.CDS2 | 23909158 | 23909260 |
| chr_2 | g7472 | g7472.t2 | exon | g7472.t2.exon3 | 23909325 | 23909847 |
| chr_2 | g7472 | g7472.t2 | cds | g7472.t2.CDS3 | 23909325 | 23909847 |
| chr_2 | g7472 | g7472.t2 | exon | g7472.t2.exon4 | 23909917 | 23910463 |
| chr_2 | g7472 | g7472.t2 | cds | g7472.t2.CDS4 | 23909917 | 23910463 |
| chr_2 | g7472 | g7472.t2 | exon | g7472.t2.exon5 | 23910777 | 23910908 |
| chr_2 | g7472 | g7472.t2 | cds | g7472.t2.CDS5 | 23910777 | 23910880 |
| chr_2 | g7472 | g7472.t2 | TSS | g7472.t2 | 23911272 | 23911272 |
Sequences
>g7472.t2 Gene=g7472 Length=1684
AGCAAGTATAGAGAAAGAAAATCCAGGAATGCTTAAGGAATCTGTACCGGATTTAACAGA
GAGAAGTAATTTTGACCACAACTTTAATCGTGGAGATATTATTATAAAAAATTCATTGGA
TGCAACACCAAGGTATAAATGTCATGTATGTGATCATTCTGACTGTAAAAACGATACATC
GATCGGAGATCATGTATGTTTAAATGCTATAACGTGCTGGAAATCTAGAGTTCGAGATTC
AAGTGGATTAGAAAGAGTAACGCGTGGATGCACAACAAAATCTGAGCACTTGCCAATTTA
TTGTAGTCAAAGAGATGTCAACAATTCAGGTCCAAAAAAACGTGATGCAGCATCTTCAAA
TGAAAGCAGTGGTTTGGGAACATATAATATTGAATGCTGTACTGGAGATTTTTGTAATAG
CGGTAGCTTTCCCGCTCTACCTCCCCTCAAGAAAGAACTTCCATCGGATACAACTACAGA
TGACATTATAAAGTTGTGTTTAGCAATTTTTGGACCTGTTGTAATAATCGGCTTAATTGC
AATCGGTATAATTTTATTCATGAGACGAAATCATAAAAGAAGGCTGATAGATGCTAGAAA
TCAACAAGATGCTGACATATATTACGCAAGCGACGATTTATTAAAACGTTCACATGCTTG
TGGCGATTCAACTTTAAGAGAATATTTCGATCAATCTGTTACATCAGGCTCGGGTAGCGG
TTTGCCATTGTTGATTCAGAGAACTCTCGCAAGACAAGTGACTTTGGCTGAATGCATTGG
ACGAGGTCGTTATGGTGAAGTTTGGCGTGCTGTTTGGCATGGTGAAAATGTCGCTGTTAA
AATCTTCTTCAGTCGTGATGAAGAATCTTGGAAACGAGAAACTGAAATATATTCAACAGT
TCTTTTACGTCATGAAAATATTCTCGGGTATATTGGTTCAGATATGACATCAAGAAATTC
ATGCACACAATTATGGCTGATCACACATTATTATCAACTCGGTTCACTCTACGATCATCT
TAACAGAACAGCTCTTACACATCATCAAATGATGACAATCTGCCTGTCTATTGCATCAGG
ATTAGTTCATTTGCATACAGAGATTTTTGGGAAACAAGGAAAACCGGCTATTGCACATCG
CGATTTAAAATCTAAAAATATTTTAGTAAAAATGAATGGTCAATGTGTCATTGCTGATAT
GGGACTTGCTGTTACACATACGCAAAAGGATGGAAAAATTGATATTGGTAATAATCCAAA
AGTTGGCACTAAACGTTATATGGCACCCGAAGTTTTAGATGAAAGTATCAATATGCAATG
CTTCGAATCATTACGACGTGCTGACATTTATGCAATTGGTCTCTTATTCTGGGAAGTGTG
TAGAAGAACACTCAGTAATGGAATAGCTGAAGAATATAAAGTTCCATATTACGATTGTGT
TCCATCAGATCCATCATTTGAAGAAATGCGTAAAGTTGTTTGTGTCGAATCAATTCGTCC
ATCAATTCCTAACAGATGGATATCAGATCCAATATTAAATTCGTTATCAAAACTTATGAA
AGAGTGCTGGCATCAAAATCCAAATGTGCGACTACCTGCATTAAGAATCAAAAAGTCACT
TTTTAAGATGGCTGCAAACGATGAAAATATAAAACTAAACTATAATGGTGAGATTTGTGT
TTAA
>g7472.t2 Gene=g7472 Length=551
MLKESVPDLTERSNFDHNFNRGDIIIKNSLDATPRYKCHVCDHSDCKNDTSIGDHVCLNA
ITCWKSRVRDSSGLERVTRGCTTKSEHLPIYCSQRDVNNSGPKKRDAASSNESSGLGTYN
IECCTGDFCNSGSFPALPPLKKELPSDTTTDDIIKLCLAIFGPVVIIGLIAIGIILFMRR
NHKRRLIDARNQQDADIYYASDDLLKRSHACGDSTLREYFDQSVTSGSGSGLPLLIQRTL
ARQVTLAECIGRGRYGEVWRAVWHGENVAVKIFFSRDEESWKRETEIYSTVLLRHENILG
YIGSDMTSRNSCTQLWLITHYYQLGSLYDHLNRTALTHHQMMTICLSIASGLVHLHTEIF
GKQGKPAIAHRDLKSKNILVKMNGQCVIADMGLAVTHTQKDGKIDIGNNPKVGTKRYMAP
EVLDESINMQCFESLRRADIYAIGLLFWEVCRRTLSNGIAEEYKVPYYDCVPSDPSFEEM
RKVVCVESIRPSIPNRWISDPILNSLSKLMKECWHQNPNVRLPALRIKKSLFKMAANDEN
IKLNYNGEICV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g7472.t2 | Gene3D | G3DSA:2.10.60.10 | CD59 | 33 | 150 | 1.4E-10 |
| 9 | g7472.t2 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 207 | 323 | 9.6E-53 |
| 10 | g7472.t2 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 324 | 541 | 8.2E-57 |
| 4 | g7472.t2 | PANTHER | PTHR23255 | TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II | 32 | 543 | 2.5E-230 |
| 5 | g7472.t2 | PANTHER | PTHR23255:SF72 | RECEPTOR PROTEIN SERINE/THREONINE KINASE | 32 | 543 | 2.5E-230 |
| 3 | g7472.t2 | Pfam | PF01064 | Activin types I and II receptor domain | 36 | 131 | 2.2E-7 |
| 1 | g7472.t2 | Pfam | PF08515 | Transforming growth factor beta type I GS-motif | 215 | 242 | 3.7E-13 |
| 2 | g7472.t2 | Pfam | PF00069 | Protein kinase domain | 247 | 529 | 5.4E-35 |
| 12 | g7472.t2 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 1 | 152 | - |
| 13 | g7472.t2 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 153 | 177 | - |
| 11 | g7472.t2 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 178 | 551 | - |
| 16 | g7472.t2 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 250 | 271 | - |
| 15 | g7472.t2 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 368 | 380 | - |
| 19 | g7472.t2 | ProSiteProfiles | PS51256 | GS domain profile. | 214 | 243 | 15.936 |
| 20 | g7472.t2 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 244 | 532 | 36.414 |
| 17 | g7472.t2 | SMART | SM00467 | GS_4 | 214 | 244 | 1.4E-12 |
| 18 | g7472.t2 | SMART | SM00220 | serkin_6 | 244 | 533 | 2.5E-23 |
| 6 | g7472.t2 | SUPERFAMILY | SSF57302 | Snake toxin-like | 35 | 138 | 6.18E-8 |
| 7 | g7472.t2 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 220 | 534 | 7.96E-68 |
| 14 | g7472.t2 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 156 | 178 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0005524 | ATP binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
| GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | BP |
| GO:0004675 | transmembrane receptor protein serine/threonine kinase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K04675 (activin receptor type-1)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
