Gene loci information

Transcript annotation

  • This transcript has been annotated as Sodium/hydrogen exchanger 7.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_2 g7512 g7512.t6 TSS g7512.t6 24141805 24141805
chr_2 g7512 g7512.t6 isoform g7512.t6 24141868 24146415
chr_2 g7512 g7512.t6 exon g7512.t6.exon1 24141868 24141997
chr_2 g7512 g7512.t6 cds g7512.t6.CDS1 24141868 24141997
chr_2 g7512 g7512.t6 exon g7512.t6.exon2 24142112 24142204
chr_2 g7512 g7512.t6 cds g7512.t6.CDS2 24142112 24142204
chr_2 g7512 g7512.t6 exon g7512.t6.exon3 24142889 24143763
chr_2 g7512 g7512.t6 cds g7512.t6.CDS3 24142889 24143763
chr_2 g7512 g7512.t6 exon g7512.t6.exon4 24143823 24143994
chr_2 g7512 g7512.t6 cds g7512.t6.CDS4 24143823 24143994
chr_2 g7512 g7512.t6 exon g7512.t6.exon5 24144053 24144363
chr_2 g7512 g7512.t6 cds g7512.t6.CDS5 24144053 24144363
chr_2 g7512 g7512.t6 exon g7512.t6.exon6 24144756 24144874
chr_2 g7512 g7512.t6 cds g7512.t6.CDS6 24144756 24144874
chr_2 g7512 g7512.t6 exon g7512.t6.exon7 24144932 24145143
chr_2 g7512 g7512.t6 cds g7512.t6.CDS7 24144932 24145143
chr_2 g7512 g7512.t6 exon g7512.t6.exon8 24145811 24146415
chr_2 g7512 g7512.t6 cds g7512.t6.CDS8 24145811 24145845
chr_2 g7512 g7512.t6 TTS g7512.t6 NA NA

Sequences

>g7512.t6 Gene=g7512 Length=2517
ATGAAAACTCTAATAATTGTGACTTTATTAGGATTAATAAATGACATAAGAGCAGACAAT
TTTGATATTTTAATAGATACAAAAGCAAACTCTATTCATCGACTGGATTCTTTGAATTTA
TTGATTTATTGTTCACTATTGGCACTCACTGTTCTGACAATATGGGTTTTTAAGTACAGA
AGAGTATCGTGGTTGAATGAGACAGGCTTAGCAGTTATTTATGGTCTCATTGTAGGAGCG
ATAATTCGTTTTGCTGGAAACAGTTCACCAACAACACATTTACGTGTTGAAGCTGATAAG
TCAACAAAATACAATGACACTCTACCACCTGATGCTTTGTGGTTAAAATTTCCAGGAAAT
TTAAATATTTCTGGCCCAACACAAAATCAAACTTATGCATACTCATTTCGTGGTCAACTT
TATGGCAATTTAAATGAAATCGATTTGAAAGCAACTTTCGATCCAGAAATTTTTTTCAAC
ATTATTCTACCGCCAATTATTTTCTATGCTGGTTATAGCTTGAAGCGAAAATATTTCTTT
AGAAATTTGGGAACAATTCTAACTTTTGCTATAATTGGAACAACTCTTTCGGCATTGCTG
ATTGGTGCACTTATGTATTGCTTTGTACAACTGATTTCAATTCGCGAAAGCTTTACCTTC
TTAGACACACTTTATTTTGGTGCACTCATAAGTCCAACCGATCCGCTCACAATTTTGGCA
ATATTTAGTGAGAAAAATGTTGATGTTAATCTATACGCTCTGGTTTTTGGTGAGAGCGTG
CTCAATGATGCCGTTGCAATAGTTTTGAGTGGAGCTATTCAAAATTATGGCGAGCATTAT
TCAAAAACAGGAGATTTTGAGACACATGCGTTTATACATGCTCTTAAAGACTTCTTTTTT
ATATTTTTCTTCTCACTGGTTGTCGGCACTTCAATGGGCTGTCTCACATCGCTTATGACA
AAGTTTACAAAAATTAGAGAATTCCCGCTACTTGAATCTGCATTATTTGTGCTCATGTCG
TACAGTACTTTCCTCATTGCTGAGGTTTTTGAATTGACTGGAGTTGTAGCTGTGCTATTT
TGTGGAATTTGTCAAGCACATTATACATTCAATAATTTATCAGAAGAGTCAAGGACAAGA
ACAAAGCAGTTGTTTGAGCTTTTGAACTTTTTAGCAGAAAATTTTATCTTTTCATATATT
GGTGTGTCGATGTTTTCATTTCCTCGACATCATTTTGATGCTCTTTTCATCATTGGTGGA
TTTTTATGTGCAATGATTGGTAGAGCAGTAAATGTTTATCCTTTAGCATGGGTAATTAAC
TTGGGACGAAAGCCTAAAATGCCTTGGAACTTTCAACATATGTTGTTCTTTGCTGGTCTT
CGTGGTGCAATGTCTTTTGCTCTTGCGATTCGCAACACTGTCTCAGAAGCACGTCAAACT
ATGCTCACATGTACATCATTAATTGTAATTGTGTCAGTACTTTTTCAAGGTGGTGCAGCA
AATTTCGTCCTACAATTTCTAAAAATTCCAATTGGAGTTGAAGATGAAACAGAGCAGCTA
ACTTATCAGTCTGTCAAAAGTGATTTGGAAAGTCCTGATCCCCATTCACCAAGTGGTAGT
GATCAACCTCAAACAAGTACATCAACTAGAAAGAATGAAAAAGCATTGTTGGCTAGAATA
TGGGGAAATTTCGATTCAAGATATATGAAGCCATTTTTAACAAATTCACGTCCAACACTG
TTAGAAACATTACCAGAATTTTTGACACCACTTGCACGAGTGCTTACTACAACCGAACAA
TTAAATCAAAGTGGTCGTACTAGGAAACTCGATTCAGATTCAGATTTATGCATAGATGAA
ACAAATGGCGGTGGTGGTGGAAGTACGAGAAGAAATTCAATAAGTCGAGTGATCCTCATT
CATCAGCTATTATTTGAACACACATAAATATACTTATTATTATTTTCATTTGTTGATCCT
TGGTTCCTCGGTCTCAGAGTCTATTAATTAATTATAACCCTTGTTAAAATTTTACCTTCC
TCGTTAGCTTATAATTATTACAAACAAACCAACCAACAAAATAATTGTATTCTGGGGGTG
CTACATAGTTATTATTAGAAATTTTAAATTTCATTTTATTATTTTATCGAAAAAAAAGGA
AAAGGAATGTGAAAATGAAAATTTTAAATATTATTATTGAACTGTGATTTTATAAAAAGA
AAAAAATTGGTTTATTTAGTTTATAGGTTGATAAAAATTTTACCGAAAGAAGAGTATAGC
ATGTCAAACATTTTTTCTCTATAGTTTATTTAAATTATTCAATACTTTTTTTATGTTCTA
TCTTTATAAGGTTAATCAGAATAGTTTTTCTTTTCGATTTAATAAACAACAAAATTTATT
TATTTAAGTCGCAAAAATTGCAACAACTTTAAAATGTCAGATTGTTTTCTATTTTTAGTT
TAGTAAATAAAATTTTTTTCCTATGGTGGACAAAAAAATGAAAAAATATTGCCTTTT

>g7512.t6 Gene=g7512 Length=648
MKTLIIVTLLGLINDIRADNFDILIDTKANSIHRLDSLNLLIYCSLLALTVLTIWVFKYR
RVSWLNETGLAVIYGLIVGAIIRFAGNSSPTTHLRVEADKSTKYNDTLPPDALWLKFPGN
LNISGPTQNQTYAYSFRGQLYGNLNEIDLKATFDPEIFFNIILPPIIFYAGYSLKRKYFF
RNLGTILTFAIIGTTLSALLIGALMYCFVQLISIRESFTFLDTLYFGALISPTDPLTILA
IFSEKNVDVNLYALVFGESVLNDAVAIVLSGAIQNYGEHYSKTGDFETHAFIHALKDFFF
IFFFSLVVGTSMGCLTSLMTKFTKIREFPLLESALFVLMSYSTFLIAEVFELTGVVAVLF
CGICQAHYTFNNLSEESRTRTKQLFELLNFLAENFIFSYIGVSMFSFPRHHFDALFIIGG
FLCAMIGRAVNVYPLAWVINLGRKPKMPWNFQHMLFFAGLRGAMSFALAIRNTVSEARQT
MLTCTSLIVIVSVLFQGGAANFVLQFLKIPIGVEDETEQLTYQSVKSDLESPDPHSPSGS
DQPQTSTSTRKNEKALLARIWGNFDSRYMKPFLTNSRPTLLETLPEFLTPLARVLTTTEQ
LNQSGRTRKLDSDSDLCIDETNGGGGGSTRRNSISRVILIHQLLFEHT

Protein features from InterProScan

Transcript Database ID Name Start End E.value
52 g7512.t6 MobiDBLite mobidb-lite consensus disorder prediction 524 552 -
2 g7512.t6 PANTHER PTHR10110 SODIUM/HYDROGEN EXCHANGER 20 620 2.3E-194
3 g7512.t6 PANTHER PTHR10110:SF94 SODIUM/HYDROGEN EXCHANGER 6 20 620 2.3E-194
5 g7512.t6 PRINTS PR01088 Na+/H+ exchanger isoform 6 (NHE6) signature 30 54 8.2E-15
4 g7512.t6 PRINTS PR01088 Na+/H+ exchanger isoform 6 (NHE6) signature 55 73 8.2E-15
7 g7512.t6 PRINTS PR01088 Na+/H+ exchanger isoform 6 (NHE6) signature 74 100 8.2E-15
10 g7512.t6 PRINTS PR01084 Na+/H+ exchanger signature 157 168 7.1E-18
11 g7512.t6 PRINTS PR01084 Na+/H+ exchanger signature 171 185 7.1E-18
8 g7512.t6 PRINTS PR01084 Na+/H+ exchanger signature 186 194 7.1E-18
9 g7512.t6 PRINTS PR01084 Na+/H+ exchanger signature 227 237 7.1E-18
6 g7512.t6 PRINTS PR01088 Na+/H+ exchanger isoform 6 (NHE6) signature 598 619 8.2E-15
1 g7512.t6 Pfam PF00999 Sodium/hydrogen exchanger family 46 504 6.7E-73
26 g7512.t6 Phobius SIGNAL_PEPTIDE Signal peptide region 1 18 -
27 g7512.t6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide. 1 2 -
28 g7512.t6 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide. 3 13 -
41 g7512.t6 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide. 14 18 -
25 g7512.t6 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 19 36 -
32 g7512.t6 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 37 57 -
18 g7512.t6 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 58 68 -
30 g7512.t6 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 69 86 -
19 g7512.t6 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 87 156 -
35 g7512.t6 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 157 174 -
17 g7512.t6 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 175 185 -
39 g7512.t6 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 186 212 -
24 g7512.t6 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 213 223 -
40 g7512.t6 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 224 242 -
16 g7512.t6 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 243 248 -
36 g7512.t6 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 249 273 -
23 g7512.t6 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 274 297 -
29 g7512.t6 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 298 320 -
13 g7512.t6 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 321 340 -
33 g7512.t6 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 341 368 -
21 g7512.t6 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 369 387 -
31 g7512.t6 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 388 407 -
15 g7512.t6 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 408 413 -
34 g7512.t6 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 414 439 -
20 g7512.t6 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 440 450 -
37 g7512.t6 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 451 470 -
14 g7512.t6 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 471 481 -
38 g7512.t6 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 482 504 -
22 g7512.t6 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 505 648 -
12 g7512.t6 SignalP_EUK SignalP-TM SignalP-TM 1 18 -
53 g7512.t6 TIGRFAM TIGR00840 b_cpa1: sodium/hydrogen exchanger 3 151 517 4.3E-95
49 g7512.t6 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 38 57 -
48 g7512.t6 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 64 86 -
47 g7512.t6 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 157 174 -
51 g7512.t6 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 187 209 -
46 g7512.t6 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 224 243 -
42 g7512.t6 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 298 320 -
50 g7512.t6 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 342 364 -
44 g7512.t6 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 385 407 -
45 g7512.t6 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 417 439 -
43 g7512.t6 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 481 503 -

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0055085 transmembrane transport BP
GO:0015385 sodium:proton antiporter activity MF
GO:0016021 integral component of membrane CC
GO:0006885 regulation of pH BP
GO:0015299 solute:proton antiporter activity MF
GO:0006812 cation transport BP
GO:0006814 sodium ion transport BP

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values