General information for g7588.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial.
Parent gene
- The parent gene g7588 is located on chr_2: 24742621..24743704 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7588 | g7588.t1 | TTS | g7588.t1 | 24742066 | 24742066 |
| chr_2 | g7588 | g7588.t1 | isoform | g7588.t1 | 24742231 | 24743704 |
| chr_2 | g7588 | g7588.t1 | exon | g7588.t1.exon1 | 24742231 | 24742364 |
| chr_2 | g7588 | g7588.t1 | cds | g7588.t1.CDS1 | 24742231 | 24742364 |
| chr_2 | g7588 | g7588.t1 | exon | g7588.t1.exon2 | 24742440 | 24743127 |
| chr_2 | g7588 | g7588.t1 | cds | g7588.t1.CDS2 | 24742440 | 24743127 |
| chr_2 | g7588 | g7588.t1 | exon | g7588.t1.exon3 | 24743579 | 24743704 |
| chr_2 | g7588 | g7588.t1 | cds | g7588.t1.CDS3 | 24743579 | 24743704 |
| chr_2 | g7588 | g7588.t1 | TSS | g7588.t1 | 24743809 | 24743809 |
Sequences
>g7588.t1 Gene=g7588 Length=948
ATGGCATTCCGTATAATAAAATTGACTCCAAATTTTGCACGCATGATGTCAACAAGTGCA
ACAAAAGTTGGGTTCATTGGTTTGGGACAAATGGGAAATCGTATGGCTACAAATCTAATC
AATAAGGGCTACAAATTGAATGTCTTTGATGTTTCACCAGAAGCATGTGATGCGATGAAA
GCAAAAGGTGCTCAAGTCTACAAAACCACACAAGAGTTGGCAAAGGAGTCAGAATTTGTT
GTCACAATGCTTCCTAATAATGATATCGTAAAAGAAACATATGAAGTCATGATTAAGGAT
GGTGTAAATAACAAAACAATGTTTGTCGATTCCTCAACAGTTGATCCATCAGTCTCACAG
TATGTGCAAAAAATTGTATCTAAAGCTGGCGCCAGATTTGTTGACGCTCCAGTATCGGGA
GGTGTCATGGGTGCTCAGAATGCAACCTTGACTTTCATGGTTGGTGGTACAAAAGAGGAA
TACGAACATGTCAAGGACTTTTTAGCCGGAATGGGAAAGAAAATTACACATTGTGGCACA
TATGGTATGGGTGAAGCTGCTAAAATTTGCAATAACATGATGTTGGCTATCAGTATGATT
GGAACAGCTGAAACGATGAATTTGGCATTACGCCTTGGTTTAGATGCAAAAGTATTTAAT
GAAATTATCAACTCATCAACGGGACGTTCATGGGCATCAGAAATTAATAATCCTGTGCCA
GGACTCAATCCAGGCACTCCACCAAGTGATGGCTATAAAGGCGGTTTCTCGACAGCACTC
ATTACCAAGGACTTGGGCTTGGCAAGCAGTGTCGCAACTGGCTCGAATTCTCCCATCATG
CTTGGCGCCCTTGCTCATCACATTTATCGTTTAATGTGTACCCACGATCTGGGCAATAAG
GACTTTTCAGTTATATACGACTTCATTAAAAACAAGTCAGGAAAATAA
>g7588.t1 Gene=g7588 Length=315
MAFRIIKLTPNFARMMSTSATKVGFIGLGQMGNRMATNLINKGYKLNVFDVSPEACDAMK
AKGAQVYKTTQELAKESEFVVTMLPNNDIVKETYEVMIKDGVNNKTMFVDSSTVDPSVSQ
YVQKIVSKAGARFVDAPVSGGVMGAQNATLTFMVGGTKEEYEHVKDFLAGMGKKITHCGT
YGMGEAAKICNNMMLAISMIGTAETMNLALRLGLDAKVFNEIINSSTGRSWASEINNPVP
GLNPGTPPSDGYKGGFSTALITKDLGLASSVATGSNSPIMLGALAHHIYRLMCTHDLGNK
DFSVIYDFIKNKSGK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g7588.t1 | Gene3D | G3DSA:3.40.50.720 | - | 17 | 180 | 5.3E-54 |
| 9 | g7588.t1 | Gene3D | G3DSA:1.10.1040.10 | - | 182 | 315 | 8.2E-42 |
| 3 | g7588.t1 | PANTHER | PTHR22981 | 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED | 11 | 313 | 3.9E-115 |
| 4 | g7588.t1 | PANTHER | PTHR22981:SF7 | 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL | 11 | 313 | 3.9E-115 |
| 10 | g7588.t1 | PIRSF | PIRSF000103 | HIBADH | 15 | 315 | 3.7E-75 |
| 2 | g7588.t1 | Pfam | PF03446 | NAD binding domain of 6-phosphogluconate dehydrogenase | 22 | 179 | 2.2E-49 |
| 1 | g7588.t1 | Pfam | PF14833 | NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase | 182 | 308 | 3.7E-29 |
| 11 | g7588.t1 | ProSitePatterns | PS00895 | 3-hydroxyisobutyrate dehydrogenase signature. | 25 | 38 | - |
| 5 | g7588.t1 | SUPERFAMILY | SSF51735 | NAD(P)-binding Rossmann-fold domains | 21 | 180 | 2.82E-44 |
| 6 | g7588.t1 | SUPERFAMILY | SSF48179 | 6-phosphogluconate dehydrogenase C-terminal domain-like | 181 | 311 | 1.93E-35 |
| 7 | g7588.t1 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM | 1 | 15 | - |
| 12 | g7588.t1 | TIGRFAM | TIGR01692 | HIBADH: 3-hydroxyisobutyrate dehydrogenase | 25 | 309 | 1.4E-106 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0050661 | NADP binding | MF |
| GO:0008442 | 3-hydroxyisobutyrate dehydrogenase activity | MF |
| GO:0051287 | NAD binding | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K23146 (3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
