General information for g7588.t3
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial.
Parent gene
- The parent gene g7588 is located on chr_2: 24742621..24743704 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7588 | g7588.t3 | TTS | g7588.t3 | 24742066 | 24742066 |
| chr_2 | g7588 | g7588.t3 | isoform | g7588.t3 | 24742231 | 24742855 |
| chr_2 | g7588 | g7588.t3 | exon | g7588.t3.exon1 | 24742231 | 24742364 |
| chr_2 | g7588 | g7588.t3 | cds | g7588.t3.CDS1 | 24742231 | 24742364 |
| chr_2 | g7588 | g7588.t3 | exon | g7588.t3.exon2 | 24742446 | 24742855 |
| chr_2 | g7588 | g7588.t3 | cds | g7588.t3.CDS2 | 24742446 | 24742827 |
| chr_2 | g7588 | g7588.t3 | TSS | g7588.t3 | 24743809 | 24743809 |
Sequences
>g7588.t3 Gene=g7588 Length=544
TGTTGACGCTCCAGTATCGGGAGGTGTCATGGGTGCTCAGAATGCAACCTTGACTTTCAT
GGTTGGTGGTACAAAAGAGGAATACGAACATGTCAAGGACTTTTTAGCCGGAATGGGAAA
GAAAATTACACATTGTGGCACATATGGTATGGGTGAAGCTGCTAAAATTTGCAATAACAT
GATGTTGGCTATCAGTATGATTGGAACAGCTGAAACGATGAATTTGGCATTACGCCTTGG
TTTAGATGCAAAAGTATTTAATGAAATTATCAACTCATCAACGGGACGTTCATGGGCATC
AGAAATTAATAATCCTGTGCCAGGACTCAATCCAGGCACTCCACCAAGTGATGGCTATAA
AGGCGGTTTCTCGACAGCACTCATTACCAAGGACTTGGGCTTGGCAAGCACAACTGGCTC
GAATTCTCCCATCATGCTTGGCGCCCTTGCTCATCACATTTATCGTTTAATGTGTACCCA
CGATCTGGGCAATAAGGACTTTTCAGTTATATACGACTTCATTAAAAACAAGTCAGGAAA
ATAA
>g7588.t3 Gene=g7588 Length=171
MGAQNATLTFMVGGTKEEYEHVKDFLAGMGKKITHCGTYGMGEAAKICNNMMLAISMIGT
AETMNLALRLGLDAKVFNEIINSSTGRSWASEINNPVPGLNPGTPPSDGYKGGFSTALIT
KDLGLASTTGSNSPIMLGALAHHIYRLMCTHDLGNKDFSVIYDFIKNKSGK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g7588.t3 | Gene3D | G3DSA:3.40.50.12340 | - | 1 | 38 | 0.00e+00 |
| 8 | g7588.t3 | Gene3D | G3DSA:1.10.1040.10 | - | 40 | 171 | 0.00e+00 |
| 3 | g7588.t3 | PANTHER | PTHR22981 | 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED | 2 | 169 | 0.00e+00 |
| 4 | g7588.t3 | PANTHER | PTHR22981:SF7 | 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL | 2 | 169 | 0.00e+00 |
| 2 | g7588.t3 | Pfam | PF03446 | NAD binding domain of 6-phosphogluconate dehydrogenase | 2 | 37 | 1.00e-07 |
| 1 | g7588.t3 | Pfam | PF14833 | NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase | 40 | 164 | 0.00e+00 |
| 5 | g7588.t3 | SUPERFAMILY | SSF51735 | NAD(P)-binding Rossmann-fold domains | 2 | 38 | 3.84e-05 |
| 6 | g7588.t3 | SUPERFAMILY | SSF48179 | 6-phosphogluconate dehydrogenase C-terminal domain-like | 39 | 167 | 0.00e+00 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0050661 | NADP binding | MF |
| GO:0051287 | NAD binding | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed