General information for g7716.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Myotubularin-related protein 8.
Parent gene
- The parent gene g7716 is located on chr_2: 25435961..25442759 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7716 | g7716.t1 | TTS | g7716.t1 | 25435619 | 25435619 |
| chr_2 | g7716 | g7716.t1 | isoform | g7716.t1 | 25435961 | 25442759 |
| chr_2 | g7716 | g7716.t1 | exon | g7716.t1.exon1 | 25435961 | 25436098 |
| chr_2 | g7716 | g7716.t1 | cds | g7716.t1.CDS1 | 25435961 | 25436098 |
| chr_2 | g7716 | g7716.t1 | exon | g7716.t1.exon2 | 25436172 | 25436510 |
| chr_2 | g7716 | g7716.t1 | cds | g7716.t1.CDS2 | 25436172 | 25436510 |
| chr_2 | g7716 | g7716.t1 | exon | g7716.t1.exon3 | 25436590 | 25437015 |
| chr_2 | g7716 | g7716.t1 | cds | g7716.t1.CDS3 | 25436590 | 25437015 |
| chr_2 | g7716 | g7716.t1 | exon | g7716.t1.exon4 | 25437077 | 25437141 |
| chr_2 | g7716 | g7716.t1 | cds | g7716.t1.CDS4 | 25437077 | 25437141 |
| chr_2 | g7716 | g7716.t1 | exon | g7716.t1.exon5 | 25437202 | 25437249 |
| chr_2 | g7716 | g7716.t1 | cds | g7716.t1.CDS5 | 25437202 | 25437249 |
| chr_2 | g7716 | g7716.t1 | exon | g7716.t1.exon6 | 25437894 | 25438170 |
| chr_2 | g7716 | g7716.t1 | cds | g7716.t1.CDS6 | 25437894 | 25438170 |
| chr_2 | g7716 | g7716.t1 | exon | g7716.t1.exon7 | 25438230 | 25438648 |
| chr_2 | g7716 | g7716.t1 | cds | g7716.t1.CDS7 | 25438230 | 25438648 |
| chr_2 | g7716 | g7716.t1 | exon | g7716.t1.exon8 | 25441414 | 25441576 |
| chr_2 | g7716 | g7716.t1 | cds | g7716.t1.CDS8 | 25441414 | 25441576 |
| chr_2 | g7716 | g7716.t1 | exon | g7716.t1.exon9 | 25441986 | 25442102 |
| chr_2 | g7716 | g7716.t1 | cds | g7716.t1.CDS9 | 25441986 | 25442102 |
| chr_2 | g7716 | g7716.t1 | exon | g7716.t1.exon10 | 25442481 | 25442759 |
| chr_2 | g7716 | g7716.t1 | cds | g7716.t1.CDS10 | 25442481 | 25442759 |
| chr_2 | g7716 | g7716.t1 | TSS | g7716.t1 | NA | NA |
Sequences
>g7716.t1 Gene=g7716 Length=2271
ATGAATAGAATTTCTGACTATACTGATATCGAAGACAACGCAAACTGTAGTGACTTTAAG
CAAAACTTTGACTTAGTTTCGCCCGAAGAAATTCAATATTATAGTGAACTACTCACACAA
GACTTTGAAGAACTCAATAGAAAATCATGCATATTTGGACTTCCATTTCCTCAAAAAATT
GTGGATCTTAGAAAATGGATCGAAGAGAACTTGCATCCACAATTGCAGCTTCATGAGAAC
ATACCTACATTCTTTCATAATATTCTTGTGCTGAGAAAGGTTGAAAATGTACGAATGATT
GATAGATATAATAGCAAAAATTCAATTGTTGGAACACTCTATTTGACCGCAACTCACCTT
ATATTTGTAGATCCCGAGGCAAATAAAGAAACCTGGATTCTTCATATGCATATTGCAAAC
ATAGAAAAACAGCCATTGAGTACAACTGGATCTCCACTTTTAATTCGATGTAAAACATTT
CTATCAGTGACGTTTGTAATTGCAAAAGAGCGTGAATGTCATGATGTTTATACCACTCTT
ATTAAACTTTGTCAACCAGTCAATATTCAAAATCTCTACTGTTTTCAATACACATCAAGT
AGTGAGGAGTTGAGTAAATCCGCAGGATGGGACTTCTTTAAATTAGAAAATGAATACAAG
CGAATGAAAGTACCAAACGATTATTGGCAATTGACTACAATGAACAAAAATTATGAGCTA
TGTGATACATATCCAAGCCAAATTTACATTCCAACTACAGTTGACAAAACAGTTTTACTA
GGAAGTTCAAGATTTCGTAGCAAAGGACGTTTACCTGCTTTGACATATTTGCACCCAAAC
AAAGCATCTATATGTCGATGCTCACAACCTTTGTCAGGTTTCTCTGCTCGTTGTGTTGAA
GACGAACAAATGTTGCAGGAAATTCGTAAAACAAATCCCAATTCCAACATTCTTTATGTA
GTAGATACACGACCAAGGATTAATGCAATGGCAAATAGAGCTGCCGGCAAGGGCTACGAA
AACGAATTATTCTATGAAAATACAAAATTTCACTTTTTGGGTATAGAAAATATTCATACA
ATGAGAGCGAGTTTGCAAAAGCTGATTGAGACGTGTGAGCAAAAATCAATGAGTGGATTT
TTAAGTGCACTCGAATCGTCAGGATGGTTGAAGCACATTCGTTCAATGTTGGATACATCA
TATTTTATTGCAAATGCTGTTTACAAAGGAATTTCTGTAGTTGTACATTGCTCAGATCCA
TTCTACCGTACAATTAAAGGTTTTCAATCTCTTATTGAAAAAGATTGGCTTTCCTTTGGT
CATAAATTTAGCGAACGATGTGGGCATTTGCAAACCGATCCAAAAGAGATTTCACCCATA
TTTACACAGTTTTTGGAGAGCGTATGGCAAATAATGCAACAGCGAGTTGATGCATTTGAA
TTTAATGAAAGATTTTTATTGATTCTTCATGACCATGTTATGAGCTGTCAATTTGGTACA
TTTATTGGAAATTGTGAAAAAGATAGAATAGACCTTAAATTGTCTGAAAAGACTTTTTCG
CTTTGGGGATACATGGCAAATCATATGAATGAATATTTAAACCCAATTTATAAGCCAGGA
GAGGTCGATGATATCATTGTTCCTAATCTTGCTCCTCAATGCATAAAATATTGGAGAGGC
ATGTATAGTAGATTCGAGAGCGGTGTTCATCCGCGAGAGGATTTATCTGACTTATTGCTA
GCAAATAAAGAGCACTGTAGTTCTCTCGATGACCATGTGCAACACTTAACGAAGCGCATC
GGAAATTTAAAAAATTTGATATCCAAATCAGCAAAAAAATTACAAGCAAATAGTGCAACA
CTTTTGCAAAACGCAACTGGAAAAAATAGTACAGACAATAAGTTTAACTATGATAATAAA
AAATTGAGCGAGCTTCAATCAGCTGATCACGACCATCCTCTTAAATTAAATGATAATAAC
TATTCATTTTCGAATTTATCTGTATCAGACTGCAATACTGCTGAAATAGATCAAATTACA
TCTGAAATTAATTCAGTTGCTTTAGATTGGAAATCTCTAAGAAGTGCAAATGCATGTTCA
TGTTCAACTCCATTTTCACAAGAAATGAAAAAGACACACTGTTGGCGATGTGGCGAAATT
TTCTGCACGCGATGCATTGATAAGTCTATTCCTCTACCAGGACAACATTCACAAAAACCG
CGACCTGTATGTAGAACATGCTTTAAATTAGTTACAACAGTTAGTCCTTAA
>g7716.t1 Gene=g7716 Length=756
MNRISDYTDIEDNANCSDFKQNFDLVSPEEIQYYSELLTQDFEELNRKSCIFGLPFPQKI
VDLRKWIEENLHPQLQLHENIPTFFHNILVLRKVENVRMIDRYNSKNSIVGTLYLTATHL
IFVDPEANKETWILHMHIANIEKQPLSTTGSPLLIRCKTFLSVTFVIAKERECHDVYTTL
IKLCQPVNIQNLYCFQYTSSSEELSKSAGWDFFKLENEYKRMKVPNDYWQLTTMNKNYEL
CDTYPSQIYIPTTVDKTVLLGSSRFRSKGRLPALTYLHPNKASICRCSQPLSGFSARCVE
DEQMLQEIRKTNPNSNILYVVDTRPRINAMANRAAGKGYENELFYENTKFHFLGIENIHT
MRASLQKLIETCEQKSMSGFLSALESSGWLKHIRSMLDTSYFIANAVYKGISVVVHCSDP
FYRTIKGFQSLIEKDWLSFGHKFSERCGHLQTDPKEISPIFTQFLESVWQIMQQRVDAFE
FNERFLLILHDHVMSCQFGTFIGNCEKDRIDLKLSEKTFSLWGYMANHMNEYLNPIYKPG
EVDDIIVPNLAPQCIKYWRGMYSRFESGVHPREDLSDLLLANKEHCSSLDDHVQHLTKRI
GNLKNLISKSAKKLQANSATLLQNATGKNSTDNKFNYDNKKLSELQSADHDHPLKLNDNN
YSFSNLSVSDCNTAEIDQITSEINSVALDWKSLRSANACSCSTPFSQEMKKTHCWRCGEI
FCTRCIDKSIPLPGQHSQKPRPVCRTCFKLVTTVSP
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g7716.t1 | CDD | cd13210 | PH-GRAM_MTMR6-like | 93 | 186 | 0.000000 |
| 14 | g7716.t1 | CDD | cd15738 | FYVE_MTMR_unchar | 688 | 748 | 0.000000 |
| 9 | g7716.t1 | Gene3D | G3DSA:2.30.29.30 | - | 87 | 183 | 0.000000 |
| 10 | g7716.t1 | Gene3D | G3DSA:3.30.40.10 | Zinc/RING finger domain | 688 | 752 | 0.000000 |
| 3 | g7716.t1 | PANTHER | PTHR10807 | MYOTUBULARIN-RELATED | 90 | 651 | 0.000000 |
| 4 | g7716.t1 | PANTHER | PTHR10807:SF36 | MYOTUBULARIN-RELATED PROTEIN 8 | 90 | 651 | 0.000000 |
| 2 | g7716.t1 | Pfam | PF06602 | Myotubularin-like phosphatase domain | 192 | 509 | 0.000000 |
| 1 | g7716.t1 | Pfam | PF01363 | FYVE zinc finger | 690 | 751 | 0.000000 |
| 11 | g7716.t1 | ProSiteProfiles | PS51339 | Myotubularin phosphatase domain. | 209 | 562 | 106.245000 |
| 12 | g7716.t1 | ProSiteProfiles | PS50178 | Zinc finger FYVE/FYVE-related type profile. | 701 | 752 | 9.764000 |
| 8 | g7716.t1 | SMART | SM00064 | fyve_4 | 685 | 753 | 0.000001 |
| 5 | g7716.t1 | SUPERFAMILY | SSF50729 | PH domain-like | 90 | 197 | 0.000000 |
| 6 | g7716.t1 | SUPERFAMILY | SSF52799 | (Phosphotyrosine protein) phosphatases II | 206 | 565 | 0.000000 |
| 7 | g7716.t1 | SUPERFAMILY | SSF57903 | FYVE/PHD zinc finger | 690 | 753 | 0.000000 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0046872 | metal ion binding | MF |
| GO:0010506 | regulation of autophagy | BP |
| GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | MF |
| GO:0046856 | phosphatidylinositol dephosphorylation | BP |
| GO:0004438 | phosphatidylinositol-3-phosphatase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K18083 (myotubularin-related protein 6/7/8)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
