General information for g7777.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein.
Parent gene
- The parent gene g7777 is located on chr_2: 25923442..25925006 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7777 | g7777.t1 | isoform | g7777.t1 | 25904811 | 25924508 |
| chr_2 | g7777 | g7777.t1 | exon | g7777.t1.exon1 | 25904811 | 25905008 |
| chr_2 | g7777 | g7777.t1 | cds | g7777.t1.CDS1 | 25904811 | 25905008 |
| chr_2 | g7777 | g7777.t1 | exon | g7777.t1.exon2 | 25905079 | 25905255 |
| chr_2 | g7777 | g7777.t1 | cds | g7777.t1.CDS2 | 25905079 | 25905255 |
| chr_2 | g7777 | g7777.t1 | exon | g7777.t1.exon3 | 25905317 | 25905405 |
| chr_2 | g7777 | g7777.t1 | cds | g7777.t1.CDS3 | 25905317 | 25905405 |
| chr_2 | g7777 | g7777.t1 | exon | g7777.t1.exon4 | 25905463 | 25905567 |
| chr_2 | g7777 | g7777.t1 | cds | g7777.t1.CDS4 | 25905463 | 25905567 |
| chr_2 | g7777 | g7777.t1 | exon | g7777.t1.exon5 | 25905629 | 25906021 |
| chr_2 | g7777 | g7777.t1 | cds | g7777.t1.CDS5 | 25905629 | 25906021 |
| chr_2 | g7777 | g7777.t1 | exon | g7777.t1.exon6 | 25906077 | 25906236 |
| chr_2 | g7777 | g7777.t1 | cds | g7777.t1.CDS6 | 25906077 | 25906236 |
| chr_2 | g7777 | g7777.t1 | exon | g7777.t1.exon7 | 25906760 | 25908085 |
| chr_2 | g7777 | g7777.t1 | cds | g7777.t1.CDS7 | 25906760 | 25908085 |
| chr_2 | g7777 | g7777.t1 | exon | g7777.t1.exon8 | 25908163 | 25908325 |
| chr_2 | g7777 | g7777.t1 | cds | g7777.t1.CDS8 | 25908163 | 25908325 |
| chr_2 | g7777 | g7777.t1 | exon | g7777.t1.exon9 | 25908387 | 25908727 |
| chr_2 | g7777 | g7777.t1 | cds | g7777.t1.CDS9 | 25908387 | 25908727 |
| chr_2 | g7777 | g7777.t1 | exon | g7777.t1.exon10 | 25908801 | 25909019 |
| chr_2 | g7777 | g7777.t1 | cds | g7777.t1.CDS10 | 25908801 | 25909019 |
| chr_2 | g7777 | g7777.t1 | exon | g7777.t1.exon11 | 25924383 | 25924508 |
| chr_2 | g7777 | g7777.t1 | cds | g7777.t1.CDS11 | 25924383 | 25924508 |
| chr_2 | g7777 | g7777.t1 | TSS | g7777.t1 | 25925006 | 25925006 |
| chr_2 | g7777 | g7777.t1 | TTS | g7777.t1 | NA | NA |
Sequences
>g7777.t1 Gene=g7777 Length=3297
ATGCCAGCATTAATAGGAGTGTCAGAGTTTGTCGAAGAGACAACTGCGGATTACAAAAGT
CCAATCACGAGTACATTTGTATCAAGAATGCAAAATATGAAGCAGACGATATCGACACTC
GAAGAGACACTTGAATTTGATCGCGATGGATTGACAAAGCTGAAAAAAGCGGCAAAAGCA
ATACACAATAGCGGTAACATTCATGTGGAGAATGAGATGTGTTTAGTTCGTGCATTAGAA
AGATTAGGAACTGTAGCGTTATCAAAAGAAGAACCAGATATTGGAGCAGCATTCCTGAAA
TTCTCTGTTGTCACAAAAGAGCTGTCAGCTCTGATGAAGACCTTGATGCAAAATATTAGT
AATGTCATAATGTTCCCAGTAGACTCACTTCTCAAATCAGAGTTACGCGGTGTTAAAGGT
GAAATGAAAAGACCATTCGATAAAGCTGCCAAAGACTTTGACACAAAATATATAAAAATC
GAAAAGGAAAGAAAAGCACAAGCCAAAGAAGTAGGCATGATACGCACAGAAATATCAGCA
GCAGAAATTGCTGAAGAGATGGAAAAGGAACGGCGCGTATTTCAATTGCAAATGTGCGAA
TATCTCATCAAGTTTAATGAAATCAAAACCAAAAAAGGCATTGAATTGCTGCAACATTTA
GTTGAATATTATCATGCTCAGAATAATTATTTTAAGGATGGTCTCAAAACAATTGCTCAT
TTTGGAACATACATTGAAGACTTAAGTATGAAATTACAAGCAATTAGGCAGAAGCAGGAT
GAAGAAAAGAAAAAACTTATTGAATTAAGAACCCTTCTAAGAAGTACTCCCGATTTTGAT
AGAGTTGAAAATGTCGTAACAGACAAGGGCACAGCTTATAGTCTCCATCAGCTACAGGGC
GATAAAAACCATGGTGTAACACGTTCAGGACATTTGTATAAGAAAAGTGAGGGCAAGGTG
AGACGCGTGTGGCAAAAAAGGCGATGTCGCGTCACTGAAGATGGATTTCTTGACATTTGC
CATGCGGACGAAACGAAACCACCAACACGCGTAAATTTGCTCACCTGCCAAATCAAACCC
GTACCCGATGACAAACGGAGTTTTGATCTCATTAGTTACAATCGGCCATATCATTTCCAA
GCAGAAGATGAAGCAGATCAGAAAGCATGGATGTCAGTGTTGATTAATTGCAAAGAAAAA
GCATTAACAAAATCCTTCCAACATGAAAATCAACAACAACAAATGAGTCCAGGCTTAATG
GAGCTTCAAAAAACTCTTATTCGGCATATTCAAAATTTGCCAGGCAATGATCAATGCTGT
GATTGTGGTTCACGAAATGACGTCACATGGATAAGCATCAATTTTGGGATTATTGTTTGT
ATTCAGTGCTCAGGTGTGCATCGTGATCTTGGCGTGCATCATTCTCGAATACAATCCTTA
ACATTGGATAATTTGAAAACGGCACACTTGTTGATTGCTCGTGCAATGGGTAACAATCAG
TTGAATGAAATTCTTGAAGCAACATTAGGAAAATCAATGAAAATTCATCCTGAGTCTAGC
ATGGAAGAGCGATATGATTTTATTCGAGCCAAATATGTAGCAAAACGTTATATCATGCGA
ACGTGTGCAGACGAGAGTGATTTACGAGTAGATTTAGAACAAGCAGTGATAAATGCAGAT
CTCAGTCAGCTGTTACAAGTATGGGCAGAAGGTGCAGATTTCACAGCGCCTCTTCCTTCA
TCTGATTACGGTGAAAATGCACTTCATATTGCTGTACTTCGTGAAATGGGTTCTTCACTT
CATATAGTAGATTTTCTTATTCAAAATATGCCACCACAAGGTCTCAACAAACCGACGAAT
CCGCAAATGAATGCTGTAAGTGGTGATGATGGAAAAATGACACCATTGCATTTCTGTGCA
GCATATGATAGACGAGAATGCATGAAATTATTGTTGAGATCTGGCGCTGATATTGACATC
AAAAACTCGAGCGGAAAAACGGCATTTGATCTTGCTATTGAAAATGGTCGTGATGTGTGT
AAGGAAATGCTCGAACAAGCAATGAGAAGAGAAAAAAGCGCTTTTGATCATATCAATACT
GACTGGAATCTTCCACCACCACATGATGATGGATCAACTGACTTTTCTGATGATGATACA
GGACTCGATGAACGTATTTCTAGCTTTGCACATGGTTTAGGAACGAGTCCAAAGCAACAA
ATGAGCTTCCCACAATATGGTGCACAAAGTGGCACAGGAGCTTCAAGTCCAAGCTCAATT
ACTAGTCGATCATCACATTCTATTGCAAGTAATCAAAGTAGAAAAACTACTGGAGTAATA
AATCCAACAACAGCGTCAGCAAAGAAAAGAAATGCTCCAAATGCACCAAATTCACAGCAA
CAACAGCAACAGCCAGTTTATGGAACACTTCCACATAGTGTAGGTCGCTATCAACAGAAT
TATGATCTCTCTGATATTTATAACAACACCAATTCAACGCTACCACATCCAGCACGAAAT
TCAATGATTGAACACCAACGGCAGAACAACAATAATGTAACTGCAAATAATAACATCAAT
AGCAACAACAATAATAATAAGAATCAAGCACCACAGCAACATTTTGATAATAAAGTATAT
GAAAGATTTGAGCCATATATGATGCAAAATAAAACTAGTCATAAACGATCACCAAGTAGT
GACTCGATATCAAGAAGTATCAATTTGGCTGGTGCAAAACTTGTATTACCACCAACGGGT
GAAATTCCTCAATTAAAACCAGTGAATATGAATAGACCAAGAATTGCACCACCATCATCT
AATTCTCAAAATGAAAAATCCATATCAAATGGTCAATCAAGTGAAAGTCTGAATTCATTA
AATGATGCATCACGTGTCCAAACTGGAACTCCTTTAAGAAAATCTTTCAATGATTCAATT
TCAAATTCATTCAATGATTATGGAAAATTTGGCGAATTAGATTCATCATGTGGAACAATC
GACACTTCAAATAATTTGCATTCAAACAGTAGCTATTTAACAGATGAAGGCTCACCACGA
AGTAGTCCAGGCGGTGTTACAATACAACCAATTAATTATGCTGGCTTGAAGAGATGTCGC
GCACTTTACGATTGCAATGCAGATAATGATGATGAATTGGAGTTCAAGGAGGGGGAAATT
CTTGTTGTGCTCAATGAACGTACAGATGATGAAAATTGGATGGAAGGAGTTATTGAATCT
GATCCATCGCGTCGAGGCATGTTTCCAGTTAGTTTTGTTCACATTTTACCCGATTAA
>g7777.t1 Gene=g7777 Length=1098
MPALIGVSEFVEETTADYKSPITSTFVSRMQNMKQTISTLEETLEFDRDGLTKLKKAAKA
IHNSGNIHVENEMCLVRALERLGTVALSKEEPDIGAAFLKFSVVTKELSALMKTLMQNIS
NVIMFPVDSLLKSELRGVKGEMKRPFDKAAKDFDTKYIKIEKERKAQAKEVGMIRTEISA
AEIAEEMEKERRVFQLQMCEYLIKFNEIKTKKGIELLQHLVEYYHAQNNYFKDGLKTIAH
FGTYIEDLSMKLQAIRQKQDEEKKKLIELRTLLRSTPDFDRVENVVTDKGTAYSLHQLQG
DKNHGVTRSGHLYKKSEGKVRRVWQKRRCRVTEDGFLDICHADETKPPTRVNLLTCQIKP
VPDDKRSFDLISYNRPYHFQAEDEADQKAWMSVLINCKEKALTKSFQHENQQQQMSPGLM
ELQKTLIRHIQNLPGNDQCCDCGSRNDVTWISINFGIIVCIQCSGVHRDLGVHHSRIQSL
TLDNLKTAHLLIARAMGNNQLNEILEATLGKSMKIHPESSMEERYDFIRAKYVAKRYIMR
TCADESDLRVDLEQAVINADLSQLLQVWAEGADFTAPLPSSDYGENALHIAVLREMGSSL
HIVDFLIQNMPPQGLNKPTNPQMNAVSGDDGKMTPLHFCAAYDRRECMKLLLRSGADIDI
KNSSGKTAFDLAIENGRDVCKEMLEQAMRREKSAFDHINTDWNLPPPHDDGSTDFSDDDT
GLDERISSFAHGLGTSPKQQMSFPQYGAQSGTGASSPSSITSRSSHSIASNQSRKTTGVI
NPTTASAKKRNAPNAPNSQQQQQQPVYGTLPHSVGRYQQNYDLSDIYNNTNSTLPHPARN
SMIEHQRQNNNNVTANNNINSNNNNNKNQAPQQHFDNKVYERFEPYMMQNKTSHKRSPSS
DSISRSINLAGAKLVLPPTGEIPQLKPVNMNRPRIAPPSSNSQNEKSISNGQSSESLNSL
NDASRVQTGTPLRKSFNDSISNSFNDYGKFGELDSSCGTIDTSNNLHSNSSYLTDEGSPR
SSPGGVTIQPINYAGLKRCRALYDCNADNDDELEFKEGEILVVLNERTDDENWMEGVIES
DPSRRGMFPVSFVHILPD
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 28 | g7777.t1 | CDD | cd07604 | BAR_ASAPs | 34 | 248 | 4.9064E-123 |
| 26 | g7777.t1 | CDD | cd13251 | PH_ASAP | 297 | 404 | 1.2751E-61 |
| 27 | g7777.t1 | CDD | cd08834 | ArfGap_ASAP | 422 | 539 | 6.25346E-66 |
| 25 | g7777.t1 | CDD | cd11821 | SH3_ASAP | 1038 | 1092 | 2.61632E-28 |
| 24 | g7777.t1 | Coils | Coil | Coil | 245 | 272 | - |
| 23 | g7777.t1 | Gene3D | G3DSA:1.20.1270.60 | Arfaptin | 32 | 279 | 1.6E-68 |
| 22 | g7777.t1 | Gene3D | G3DSA:2.30.29.30 | - | 300 | 417 | 6.0E-27 |
| 20 | g7777.t1 | Gene3D | G3DSA:3.30.40.160 | - | 420 | 539 | 4.8E-39 |
| 19 | g7777.t1 | Gene3D | G3DSA:1.25.40.20 | - | 541 | 704 | 1.7E-46 |
| 21 | g7777.t1 | Gene3D | G3DSA:2.30.30.40 | SH3 Domains | 1036 | 1097 | 2.3E-18 |
| 36 | g7777.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 746 | 806 | - |
| 35 | g7777.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 936 | 974 | - |
| 6 | g7777.t1 | PANTHER | PTHR45854 | ASAP FAMILY MEMBER | 1 | 1097 | 0.0 |
| 7 | g7777.t1 | PANTHER | PTHR45854:SF3 | ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN | 1 | 1097 | 0.0 |
| 9 | g7777.t1 | PRINTS | PR00405 | HIV Rev interacting protein signature | 437 | 456 | 1.1E-9 |
| 8 | g7777.t1 | PRINTS | PR00405 | HIV Rev interacting protein signature | 456 | 473 | 1.1E-9 |
| 10 | g7777.t1 | PRINTS | PR00405 | HIV Rev interacting protein signature | 477 | 498 | 1.1E-9 |
| 12 | g7777.t1 | PRINTS | PR00452 | SH3 domain signature | 1037 | 1047 | 1.7E-5 |
| 13 | g7777.t1 | PRINTS | PR00452 | SH3 domain signature | 1051 | 1066 | 1.7E-5 |
| 11 | g7777.t1 | PRINTS | PR00452 | SH3 domain signature | 1084 | 1096 | 1.7E-5 |
| 4 | g7777.t1 | Pfam | PF16746 | BAR domain of APPL family | 34 | 266 | 2.4E-24 |
| 3 | g7777.t1 | Pfam | PF00169 | PH domain | 306 | 398 | 5.8E-9 |
| 5 | g7777.t1 | Pfam | PF01412 | Putative GTPase activating protein for Arf | 425 | 539 | 2.4E-34 |
| 2 | g7777.t1 | Pfam | PF12796 | Ankyrin repeats (3 copies) | 552 | 662 | 5.4E-11 |
| 1 | g7777.t1 | Pfam | PF14604 | Variant SH3 domain | 1041 | 1093 | 1.1E-9 |
| 41 | g7777.t1 | ProSiteProfiles | PS50003 | PH domain profile. | 305 | 399 | 12.257 |
| 40 | g7777.t1 | ProSiteProfiles | PS50115 | ARF GTPase-activating proteins domain profile. | 424 | 545 | 23.21 |
| 37 | g7777.t1 | ProSiteProfiles | PS50297 | Ankyrin repeat region circular profile. | 631 | 677 | 14.902 |
| 39 | g7777.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 631 | 663 | 11.888 |
| 38 | g7777.t1 | ProSiteProfiles | PS50002 | Src homology 3 (SH3) domain profile. | 1034 | 1098 | 26.989 |
| 30 | g7777.t1 | SMART | SM00233 | PH_update | 306 | 401 | 3.0E-16 |
| 31 | g7777.t1 | SMART | SM00105 | arf_gap_3 | 424 | 545 | 4.0E-34 |
| 32 | g7777.t1 | SMART | SM00248 | ANK_2a | 583 | 617 | 4.1 |
| 34 | g7777.t1 | SMART | SM00248 | ANK_2a | 631 | 660 | 8.0E-5 |
| 33 | g7777.t1 | SMART | SM00248 | ANK_2a | 664 | 696 | 1100.0 |
| 29 | g7777.t1 | SMART | SM00326 | SH3_2 | 1037 | 1097 | 3.0E-18 |
| 16 | g7777.t1 | SUPERFAMILY | SSF103657 | BAR/IMD domain-like | 34 | 329 | 3.49E-61 |
| 15 | g7777.t1 | SUPERFAMILY | SSF50729 | PH domain-like | 303 | 409 | 6.16E-19 |
| 18 | g7777.t1 | SUPERFAMILY | SSF57863 | ArfGap/RecO-like zinc finger | 424 | 540 | 1.44E-36 |
| 14 | g7777.t1 | SUPERFAMILY | SSF48403 | Ankyrin repeat | 544 | 704 | 8.39E-48 |
| 17 | g7777.t1 | SUPERFAMILY | SSF50044 | SH3-domain | 1019 | 1097 | 4.2E-17 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005515 | protein binding | MF |
| GO:0043547 | positive regulation of GTPase activity | BP |
| GO:0005096 | GTPase activator activity | MF |
KEGG
Orthology
- This transcript has been annotated with K12488 (Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
