General information for g7786.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative Cathepsin L1.
Parent gene
- The parent gene g7786 is located on chr_2: 26098663..26099930 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7786 | g7786.t1 | isoform | g7786.t1 | 26098663 | 26099930 |
| chr_2 | g7786 | g7786.t1 | exon | g7786.t1.exon1 | 26098663 | 26098728 |
| chr_2 | g7786 | g7786.t1 | cds | g7786.t1.CDS1 | 26098663 | 26098728 |
| chr_2 | g7786 | g7786.t1 | exon | g7786.t1.exon2 | 26098865 | 26098895 |
| chr_2 | g7786 | g7786.t1 | cds | g7786.t1.CDS2 | 26098865 | 26098895 |
| chr_2 | g7786 | g7786.t1 | exon | g7786.t1.exon3 | 26098970 | 26099339 |
| chr_2 | g7786 | g7786.t1 | cds | g7786.t1.CDS3 | 26098970 | 26099339 |
| chr_2 | g7786 | g7786.t1 | exon | g7786.t1.exon4 | 26099393 | 26099930 |
| chr_2 | g7786 | g7786.t1 | cds | g7786.t1.CDS4 | 26099393 | 26099930 |
| chr_2 | g7786 | g7786.t1 | TSS | g7786.t1 | NA | NA |
| chr_2 | g7786 | g7786.t1 | TTS | g7786.t1 | NA | NA |
Sequences
>g7786.t1 Gene=g7786 Length=1005
ATGAAGCTTTTAGTAATAGCAATTTGTTTAATTTTGGGGGTTGCACTTGCAGCTCAACTT
ACACCAGAAGAAGAAGATAGAATTTTTGAGCAATGGCTTCGTGAACACAACATTAAAGTT
CCTCATGATGAAGCTTATAAACAGTGGAAAGCAAATGTTATTCAAAGATTGAACGAAATT
GAAGCTCACAATGAAGATTTCCGTAATGGCAAAGTTAAATTTAAGCAAGTTTTGAATCAT
TTTGCTCATTTATCATCTGAAGAAATCAGTAAAACAAAACATGGTCATAAAAATATTGCT
CCAGATCCTTCAAAAGTTATACCAGTCGTTACTCGACCAAAACGTGCAGCAGATGATATT
CCTGCATATTGGAATTGGTATGAAAAAGGAATAGTTAGTCCTCCATTAGATCAAAGATGT
GGTTGTTGTTATGCGCATGCTGGAACTGGTGTTATTGAAGCTCATGCTTGTAAACATTTC
GGAAAATGCATAAAATTGTCAGAACAAGAAGCTCTGGAATGCACAAAGAAATGTGAAGGT
GGTAATTATGAAATGATTTTTCAATATGCAAAAGACAATGGTGGAATGGCTAGTGATTTA
GACCATCCGTATGTTCTTCCTGACCTTACTGAATGCTCTATTGATGTTAAAAATAATGCT
CGTGTACCAAATACTAAAGTTGTTGATTGGAAAGTAATGCCAAATGATTCTTATACTATT
ATGCATACTTTGTACAATAAAGGACCATTGTATGCTGGTCTTCATATATTCTGGAACTTT
TATTTCCATCATGAGGGAGTTTATGATACACCAAAGAATGAAACTAATGACTGGCACGCT
TTAATGTTAGTTGGATACGGGACAGAATCTGATGGAACAGATTATTGGATTGTAAGAAAT
TCGTGGAGTACAAAATGGGGAGTAAATGGATTAGCTAAGATCAAACGAGGAGTTGATATT
CTTAAAATTGAGTCAGCAGGAGTTGCTTATCCAATTCTTGAATAA
>g7786.t1 Gene=g7786 Length=334
MKLLVIAICLILGVALAAQLTPEEEDRIFEQWLREHNIKVPHDEAYKQWKANVIQRLNEI
EAHNEDFRNGKVKFKQVLNHFAHLSSEEISKTKHGHKNIAPDPSKVIPVVTRPKRAADDI
PAYWNWYEKGIVSPPLDQRCGCCYAHAGTGVIEAHACKHFGKCIKLSEQEALECTKKCEG
GNYEMIFQYAKDNGGMASDLDHPYVLPDLTECSIDVKNNARVPNTKVVDWKVMPNDSYTI
MHTLYNKGPLYAGLHIFWNFYFHHEGVYDTPKNETNDWHALMLVGYGTESDGTDYWIVRN
SWSTKWGVNGLAKIKRGVDILKIESAGVAYPILE
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 17 | g7786.t1 | CDD | cd02248 | Peptidase_C1A | 121 | 331 | 3.67139E-59 |
| 11 | g7786.t1 | Gene3D | G3DSA:3.90.70.10 | Cysteine proteinases | 21 | 332 | 5.1E-71 |
| 3 | g7786.t1 | PANTHER | PTHR12411 | CYSTEINE PROTEASE FAMILY C1-RELATED | 22 | 319 | 8.3E-48 |
| 4 | g7786.t1 | PANTHER | PTHR12411:SF57 | CATHEPSIN L1 | 22 | 319 | 8.3E-48 |
| 7 | g7786.t1 | PRINTS | PR00705 | Papain cysteine protease (C1) family signature | 137 | 152 | 2.2E-5 |
| 5 | g7786.t1 | PRINTS | PR00705 | Papain cysteine protease (C1) family signature | 279 | 289 | 2.2E-5 |
| 6 | g7786.t1 | PRINTS | PR00705 | Papain cysteine protease (C1) family signature | 295 | 301 | 2.2E-5 |
| 1 | g7786.t1 | Pfam | PF08246 | Cathepsin propeptide inhibitor domain (I29) | 29 | 88 | 2.2E-8 |
| 2 | g7786.t1 | Pfam | PF00112 | Papain family cysteine protease | 120 | 326 | 2.9E-42 |
| 13 | g7786.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 17 | - |
| 14 | g7786.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 2 | - |
| 15 | g7786.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 3 | 12 | - |
| 16 | g7786.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 13 | 17 | - |
| 12 | g7786.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 18 | 334 | - |
| 20 | g7786.t1 | SMART | SM00848 | Inhibitor_I29_2 | 29 | 89 | 2.0E-7 |
| 19 | g7786.t1 | SMART | SM00645 | pept_c1 | 120 | 332 | 1.8E-37 |
| 8 | g7786.t1 | SUPERFAMILY | SSF54001 | Cysteine proteinases | 25 | 331 | 7.45E-66 |
| 10 | g7786.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 17 | - |
| 18 | g7786.t1 | SignalP_GRAM_NEGATIVE | SignalP-noTM | SignalP-noTM | 1 | 17 | - |
| 9 | g7786.t1 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM | 1 | 17 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0008234 | cysteine-type peptidase activity | MF |
| GO:0006508 | proteolysis | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed