General information for g7787.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative Cathepsin L1.
Parent gene
- The parent gene g7787 is located on chr_2: 26100986..26102124 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g7787 | g7787.t1 | isoform | g7787.t1 | 26100986 | 26102124 |
| chr_2 | g7787 | g7787.t1 | exon | g7787.t1.exon1 | 26100986 | 26101085 |
| chr_2 | g7787 | g7787.t1 | cds | g7787.t1.CDS1 | 26100986 | 26101085 |
| chr_2 | g7787 | g7787.t1 | exon | g7787.t1.exon2 | 26101156 | 26101522 |
| chr_2 | g7787 | g7787.t1 | cds | g7787.t1.CDS2 | 26101156 | 26101522 |
| chr_2 | g7787 | g7787.t1 | exon | g7787.t1.exon3 | 26101581 | 26102124 |
| chr_2 | g7787 | g7787.t1 | cds | g7787.t1.CDS3 | 26101581 | 26102124 |
| chr_2 | g7787 | g7787.t1 | TSS | g7787.t1 | NA | NA |
| chr_2 | g7787 | g7787.t1 | TTS | g7787.t1 | NA | NA |
Sequences
>g7787.t1 Gene=g7787 Length=1011
ATGAAATTCTTTGTAGTTGCAATTTTTGCTCTCTATGGAGCTGCTCTCGTAAGCTCAGCT
CTAACTCCCGAGGAAGAAGAGAAAATTTTTGATCATTGGCTTCGTAAGCATAACGTCAAA
GTGCCTCATAATGAAGCTTATAACAAGTGGAGAGCAAATGTCATCAAGAAATTGAACAAA
ATTGAAGAACACAACGAGAATTTCCGAAGCGGCAAAGTTGGATTTGAACAAGTTTTGAAT
GATTTGTCTCATTTATCACCAGAAGAACTTAAAGCTACCAAACACGGAATTGTTATACCA
GATAATTACAAACATGATGCTGACAAAGTCGCACCTGTTGTTACACGATCAAAACGTGCT
GATATTCCAGCTTACTGGAACTGGGCTGATAAGGGTATTGTTCAACCTGTTCAATACCAA
AAGTGCTCAGACTGCTACGCTTTTGCATCAACTGGTGTAATTGAAGCTCATGCTTGTCGC
TATCAAGGCCAATGCTCAAAATTGTCTGAACAAGAATCATTGGAATGTACAAATCAATGC
AATGGTGGTTGGGATGAATATGTTTACAATTATTCAAAGAATAATGGTGGTCTTACATTG
CTTTCAAACCATCAGTACACCGTTCCAAAACTTGCTCAATGTGCATCTGATATCAAGAGA
AATCCCCGTGCCCCAAGAACTAAAGTTGTTGATTGGAAAATCATGCCAAATGATACTTAC
ACAATTATGCATCATCTTTACAACGTTGGACCAATGTTTGTTGTTGTTCACATCTACGAC
AATTTCTATCATTTAGGAGGTGGTATTTATGATGCTCCAGATACTCCAACTAAAACATGG
CATGCAATTCAACTGGTCGGATATGGTACAGAAAATGGAAAAGACTATTGGATTGTTAAA
AACTCATGGGGTACCAATTGGGGAGTAAATGGTTACGGAAAACTGATTCGAGGACGAGAC
ATCATTAACATTGAATCAACTAAAGTTTCTTATCCAATTATAGGATCATAA
>g7787.t1 Gene=g7787 Length=336
MKFFVVAIFALYGAALVSSALTPEEEEKIFDHWLRKHNVKVPHNEAYNKWRANVIKKLNK
IEEHNENFRSGKVGFEQVLNDLSHLSPEELKATKHGIVIPDNYKHDADKVAPVVTRSKRA
DIPAYWNWADKGIVQPVQYQKCSDCYAFASTGVIEAHACRYQGQCSKLSEQESLECTNQC
NGGWDEYVYNYSKNNGGLTLLSNHQYTVPKLAQCASDIKRNPRAPRTKVVDWKIMPNDTY
TIMHHLYNVGPMFVVVHIYDNFYHLGGGIYDAPDTPTKTWHAIQLVGYGTENGKDYWIVK
NSWGTNWGVNGYGKLIRGRDIINIESTKVSYPIIGS
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 18 | g7787.t1 | CDD | cd02248 | Peptidase_C1A | 123 | 332 | 3.11477E-60 |
| 12 | g7787.t1 | Coils | Coil | Coil | 47 | 67 | - |
| 11 | g7787.t1 | Gene3D | G3DSA:3.90.70.10 | Cysteine proteinases | 26 | 334 | 2.4E-71 |
| 3 | g7787.t1 | PANTHER | PTHR12411 | CYSTEINE PROTEASE FAMILY C1-RELATED | 23 | 320 | 5.6E-44 |
| 4 | g7787.t1 | PANTHER | PTHR12411:SF57 | CATHEPSIN L1 | 23 | 320 | 5.6E-44 |
| 7 | g7787.t1 | PRINTS | PR00705 | Papain cysteine protease (C1) family signature | 139 | 154 | 5.8E-6 |
| 5 | g7787.t1 | PRINTS | PR00705 | Papain cysteine protease (C1) family signature | 281 | 291 | 5.8E-6 |
| 6 | g7787.t1 | PRINTS | PR00705 | Papain cysteine protease (C1) family signature | 296 | 302 | 5.8E-6 |
| 1 | g7787.t1 | Pfam | PF08246 | Cathepsin propeptide inhibitor domain (I29) | 30 | 89 | 1.0E-7 |
| 2 | g7787.t1 | Pfam | PF00112 | Papain family cysteine protease | 122 | 329 | 1.5E-45 |
| 14 | g7787.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 19 | - |
| 15 | g7787.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 2 | - |
| 16 | g7787.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 3 | 11 | - |
| 17 | g7787.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 12 | 19 | - |
| 13 | g7787.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 20 | 336 | - |
| 23 | g7787.t1 | ProSitePatterns | PS00639 | Eukaryotic thiol (cysteine) proteases histidine active site. | 279 | 289 | - |
| 22 | g7787.t1 | ProSitePatterns | PS00640 | Eukaryotic thiol (cysteine) proteases asparagine active site. | 296 | 315 | - |
| 21 | g7787.t1 | SMART | SM00848 | Inhibitor_I29_2 | 30 | 90 | 1.5E-6 |
| 20 | g7787.t1 | SMART | SM00645 | pept_c1 | 122 | 333 | 7.8E-43 |
| 8 | g7787.t1 | SUPERFAMILY | SSF54001 | Cysteine proteinases | 23 | 327 | 1.63E-66 |
| 10 | g7787.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 19 | - |
| 19 | g7787.t1 | SignalP_GRAM_NEGATIVE | SignalP-noTM | SignalP-noTM | 1 | 20 | - |
| 9 | g7787.t1 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM | 1 | 20 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0008234 | cysteine-type peptidase activity | MF |
| GO:0006508 | proteolysis | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed