General information for g8076.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Diphosphomevalonate decarboxylase.
Parent gene
- The parent gene g8076 is located on chr_2: 28481800..28483005 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g8076 | g8076.t1 | TTS | g8076.t1 | 28481389 | 28481389 |
| chr_2 | g8076 | g8076.t1 | isoform | g8076.t1 | 28481621 | 28483005 |
| chr_2 | g8076 | g8076.t1 | exon | g8076.t1.exon1 | 28481621 | 28481716 |
| chr_2 | g8076 | g8076.t1 | cds | g8076.t1.CDS1 | 28481621 | 28481716 |
| chr_2 | g8076 | g8076.t1 | exon | g8076.t1.exon2 | 28481783 | 28482679 |
| chr_2 | g8076 | g8076.t1 | cds | g8076.t1.CDS2 | 28481783 | 28482679 |
| chr_2 | g8076 | g8076.t1 | exon | g8076.t1.exon3 | 28482790 | 28482860 |
| chr_2 | g8076 | g8076.t1 | cds | g8076.t1.CDS3 | 28482790 | 28482860 |
| chr_2 | g8076 | g8076.t1 | exon | g8076.t1.exon4 | 28482951 | 28483005 |
| chr_2 | g8076 | g8076.t1 | cds | g8076.t1.CDS4 | 28482951 | 28483005 |
| chr_2 | g8076 | g8076.t1 | TSS | g8076.t1 | 28483155 | 28483155 |
Sequences
>g8076.t1 Gene=g8076 Length=1119
ATGCAGAATTCAGTTACTGTTATTGCACCAGTAAATATAGCCGTGATTAAATATTGGGGA
AAAAGAAATGAACAATTAATTCTACCAATTAATGATTCGCTCTCCGTTACCTTATCAACT
GCTGACCTATGCAGTAAAACGACAATAACCGCAGACCCAAGTTACGAAGAAAACAAAATC
GTGTTGAATGGAAAAGAAGAGAATTTCGATAATGAACGCATCACGCGGTGTGTTGAAATG
ATCAAACATCGTGCTCTTGAGTCCGAATCTTGTTCTAAAGAATTGCTTGCATATAAAATA
CATGTTGATTCGGAAAACAACTTTCCAACAGCTGCCGGTTTAGCTAGTAGTGCTAGTGGA
TATGCATGTTTAGTATACGCACTCGCTCAACTTTATGGTCTCAAAAAACAAGAGATTAGC
GATATCGCTCGAATGGGTTCTGGTTCAGCATGTAGAAGTATTTATGGTGGTTTTGTGCAA
TGGCAAAAAGGCGTTCAATTAGATGGAAAAGATTCTATTGCAGTGCAAATTGCACCGGCA
TCACATTGGCCTGATCTTCATGTATTGATTCTTGTTGTTAATGATAGCAAAAAGAAGGTT
GGGTCGACTTCTGGAATGGCACGAAGTGTTTTGACATCAGAATTAATCAAATATCGTGTA
GAAAAATGTGTTCCTCAGCGAATTCATTCGATAACGCAGGCGATCAAAGATCGTGATTTT
TCGAAATTTGCTGAAATCACTATGAAGGACAGCAATCAATTTCATGCAATTTGCCTTGAT
ACTTATCCTCCGTGTGTTTATATGAACGATGTATCTCATGCTATCGTAAATTTTGTCCAC
GAATTTAATCGAAATGAAGGAGAAACCAAAGTGGCTTATACTTTTGATGCAGGCCCAAAT
GCTTGTTTATATCTGCCAGAGAAATACGTTAAACGTGTTCTCGCTTTCTTTAATCACGTG
CTGCCAAATGATAATCAAAATTCAGTTGAATATTTGCGTGGCACTCCTGTTGACATAGAT
GAGGAAACTGAATTTAGTCAATATACTCCATATGAAAGAAATGCTTTGAAATATATAATT
CATACAAAAGTTGGTGATGGACCTTCTATTGTTGATTAG
>g8076.t1 Gene=g8076 Length=372
MQNSVTVIAPVNIAVIKYWGKRNEQLILPINDSLSVTLSTADLCSKTTITADPSYEENKI
VLNGKEENFDNERITRCVEMIKHRALESESCSKELLAYKIHVDSENNFPTAAGLASSASG
YACLVYALAQLYGLKKQEISDIARMGSGSACRSIYGGFVQWQKGVQLDGKDSIAVQIAPA
SHWPDLHVLILVVNDSKKKVGSTSGMARSVLTSELIKYRVEKCVPQRIHSITQAIKDRDF
SKFAEITMKDSNQFHAICLDTYPPCVYMNDVSHAIVNFVHEFNRNEGETKVAYTFDAGPN
ACLYLPEKYVKRVLAFFNHVLPNDNQNSVEYLRGTPVDIDEETEFSQYTPYERNALKYII
HTKVGDGPSIVD
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g8076.t1 | Gene3D | G3DSA:3.30.230.10 | - | 5 | 178 | 0 |
| 8 | g8076.t1 | Gene3D | G3DSA:3.30.70.890 | - | 179 | 370 | 0 |
| 3 | g8076.t1 | PANTHER | PTHR10977:SF3 | DIPHOSPHOMEVALONATE DECARBOXYLASE | 2 | 372 | 0 |
| 4 | g8076.t1 | PANTHER | PTHR10977 | DIPHOSPHOMEVALONATE DECARBOXYLASE | 2 | 372 | 0 |
| 10 | g8076.t1 | PIRSF | PIRSF015950 | Mev_P_decrbx | 1 | 372 | 0 |
| 1 | g8076.t1 | Pfam | PF00288 | GHMP kinases N terminal domain | 101 | 157 | 0 |
| 2 | g8076.t1 | Pfam | PF18376 | Mevalonate 5-diphosphate decarboxylase C-terminal domain | 188 | 371 | 0 |
| 5 | g8076.t1 | SUPERFAMILY | SSF54211 | Ribosomal protein S5 domain 2-like | 4 | 184 | 0 |
| 6 | g8076.t1 | SUPERFAMILY | SSF55060 | GHMP Kinase, C-terminal domain | 186 | 370 | 0 |
| 9 | g8076.t1 | TIGRFAM | TIGR01240 | mevDPdecarb: diphosphomevalonate decarboxylase | 6 | 318 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016831 | carboxy-lyase activity | MF |
| GO:0008299 | isoprenoid biosynthetic process | BP |
| GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway | BP |
| GO:0005524 | ATP binding | MF |
| GO:0005829 | cytosol | CC |
| GO:0004163 | diphosphomevalonate decarboxylase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K01597 (diphosphomevalonate decarboxylase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
