Gene loci information

Transcript annotation

  • This transcript has been annotated as Kynurenine 3-monooxygenase.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_2 g8288 g8288.t1 TSS g8288.t1 29561664 29561664
chr_2 g8288 g8288.t1 isoform g8288.t1 29562061 29564006
chr_2 g8288 g8288.t1 exon g8288.t1.exon1 29562061 29562135
chr_2 g8288 g8288.t1 cds g8288.t1.CDS1 29562061 29562135
chr_2 g8288 g8288.t1 exon g8288.t1.exon2 29562364 29562433
chr_2 g8288 g8288.t1 cds g8288.t1.CDS2 29562364 29562433
chr_2 g8288 g8288.t1 exon g8288.t1.exon3 29562498 29562737
chr_2 g8288 g8288.t1 cds g8288.t1.CDS3 29562498 29562737
chr_2 g8288 g8288.t1 exon g8288.t1.exon4 29562799 29562886
chr_2 g8288 g8288.t1 cds g8288.t1.CDS4 29562799 29562886
chr_2 g8288 g8288.t1 exon g8288.t1.exon5 29562955 29563126
chr_2 g8288 g8288.t1 cds g8288.t1.CDS5 29562955 29563126
chr_2 g8288 g8288.t1 exon g8288.t1.exon6 29563185 29563692
chr_2 g8288 g8288.t1 cds g8288.t1.CDS6 29563185 29563692
chr_2 g8288 g8288.t1 exon g8288.t1.exon7 29563756 29564006
chr_2 g8288 g8288.t1 cds g8288.t1.CDS7 29563756 29564006
chr_2 g8288 g8288.t1 TTS g8288.t1 29564091 29564091

Sequences

>g8288.t1 Gene=g8288 Length=1404
ATGGCATTTACTAATGGGTTCACAAAACACACTAAGCAAGAATGCTTAGATATTGCAATC
GTCGGGGGTGGTCTGGTCGGTTCATTAGCAGCATTGCATATGGCAAAAAAGGGTCATAAA
GTTAGTCTTTATGAATATCGCGAGGACATTCGAACTGCTGAGCTGGTCATCGGACGAAGT
ATCAATTTGGCATTATCTGTTCGCGGACGTAAAGCATTGAAAGAGGTCGGCCTTGAAGAT
AAGCTTTTAGAACATGGGATTGCCATGTACGCACGTATGATTCATAATACTGATGGAACA
CGAAATGCAATTCCGTATGATAGACGTAATCATCAAGCTATATATTCTGTTGGTCGCAAA
TATTTGAATGAAGTTCTACTCACAGCGGCTGAAAAGTATCCAAACATAAATCTCAACTTT
AACAAGAAAATGGTCGGTGGAAAAGTGGATAAAGGCGAAGTGACTTTTATTGATACAACC
AATGAGGAGAAAAAAAATATTTTTGCCGATTTAATCATTGGATGTGATGGCGCTTTCTCA
TCTGTTCGACGCGAAATGCTCAAAAGAAATGGCTTTAATTATAGTCAAACTTACATAGAA
CATGGTTATCTTGAATTATGTATACCGCCAGCTGCAGATGGAGGATTTCAAATGCCTGAA
AATTATCTTCATATATGGCCAAGAGGAAAATTCATGATGATTGCATTGCCCAATCAAGAT
CGAACTTGGACTGTAACATTGTTCATGCCATTTGAAAATTTTGATAGTATCAAATCTTCA
GAAGAGCTTCTAAAGTTTTTTGAAATTTATTTTCCTGATGCAATTCCATTAATTGGCAAA
GAGCGTTTGGTCAAAGATTTTTTCAAAATTCCAGCTCAACATCTCATAGCAGTAAAATGT
CGTCCATATCATATATCATCAAAATGTGTTCTAATTGGAGATGCAGGGCATGCTGTTGTT
CCATTTTACGGCCAAGGAATGAATGCTGGCTTTGAAGACTGCAGTATACTTACAGAGTTA
TTTAACAAATACGGCTCTGACTTAGAAAAAATTCTCACTGAATTTAGCGAGACAAGATGG
ATCGATGCACACGCTGTTTGTGATCTAGCGATGTACAATTACATTGAAATGAGAGATTTA
GTCAACAAGAAATCATTTCTTATGAGAAAAGCATTAGATGATTTTTTGCATTGGATTGCA
CCGTCATATTGGGTTCCTCTTTATAGCAGTGTTTCATTTACATGTATGCCATATAAGAAA
TGCATTGAAAATCGTGAATGGCAGGATCGCGTTTTAAATAAAATTTTTACTGTCTGTAGT
TTTATCGGAGTAAGTTCATGCTTGTTAGGTGCTATTCACCTTTATAACACATATAACACT
ATGGAAGAATTGTCATTTAATTAA

>g8288.t1 Gene=g8288 Length=467
MAFTNGFTKHTKQECLDIAIVGGGLVGSLAALHMAKKGHKVSLYEYREDIRTAELVIGRS
INLALSVRGRKALKEVGLEDKLLEHGIAMYARMIHNTDGTRNAIPYDRRNHQAIYSVGRK
YLNEVLLTAAEKYPNINLNFNKKMVGGKVDKGEVTFIDTTNEEKKNIFADLIIGCDGAFS
SVRREMLKRNGFNYSQTYIEHGYLELCIPPAADGGFQMPENYLHIWPRGKFMMIALPNQD
RTWTVTLFMPFENFDSIKSSEELLKFFEIYFPDAIPLIGKERLVKDFFKIPAQHLIAVKC
RPYHISSKCVLIGDAGHAVVPFYGQGMNAGFEDCSILTELFNKYGSDLEKILTEFSETRW
IDAHAVCDLAMYNYIEMRDLVNKKSFLMRKALDDFLHWIAPSYWVPLYSSVSFTCMPYKK
CIENREWQDRVLNKIFTVCSFIGVSSCLLGAIHLYNTYNTMEELSFN

Protein features from InterProScan

Transcript Database ID Name Start End E.value
10 g8288.t1 Gene3D G3DSA:3.50.50.60 - 16 394 1.5E-132
4 g8288.t1 Hamap MF_01971 Kynurenine 3-monooxygenase [kmo]. 15 457 29.292517
2 g8288.t1 PANTHER PTHR46028:SF2 KYNURENINE 3-MONOOXYGENASE 14 457 2.8E-172
3 g8288.t1 PANTHER PTHR46028 KYNURENINE 3-MONOOXYGENASE 14 457 2.8E-172
8 g8288.t1 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 17 39 7.2E-17
5 g8288.t1 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 168 183 7.2E-17
7 g8288.t1 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 306 321 7.2E-17
6 g8288.t1 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 321 337 7.2E-17
1 g8288.t1 Pfam PF01494 FAD binding domain 17 339 1.9E-25
13 g8288.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 1 394 -
14 g8288.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 395 415 -
11 g8288.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 416 434 -
15 g8288.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 435 455 -
12 g8288.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 456 467 -
9 g8288.t1 SUPERFAMILY SSF51905 FAD/NAD(P)-binding domain 17 404 1.19E-50
17 g8288.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 395 414 -
16 g8288.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 435 457 -

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0006569 tryptophan catabolic process BP
GO:0019805 quinolinate biosynthetic process BP
GO:0071949 FAD binding MF
GO:0004502 kynurenine 3-monooxygenase activity MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values