Gene loci information

Transcript annotation

  • This transcript has been annotated as Mitogen-activated protein kinase kinase kinase 15.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_2 g8333 g8333.t1 TSS g8333.t1 29797320 29797320
chr_2 g8333 g8333.t1 isoform g8333.t1 29797425 29802689
chr_2 g8333 g8333.t1 exon g8333.t1.exon1 29797425 29797455
chr_2 g8333 g8333.t1 cds g8333.t1.CDS1 29797425 29797455
chr_2 g8333 g8333.t1 exon g8333.t1.exon2 29797651 29797865
chr_2 g8333 g8333.t1 cds g8333.t1.CDS2 29797651 29797865
chr_2 g8333 g8333.t1 exon g8333.t1.exon3 29797939 29798094
chr_2 g8333 g8333.t1 cds g8333.t1.CDS3 29797939 29798094
chr_2 g8333 g8333.t1 exon g8333.t1.exon4 29798163 29798750
chr_2 g8333 g8333.t1 cds g8333.t1.CDS4 29798163 29798750
chr_2 g8333 g8333.t1 exon g8333.t1.exon5 29798822 29800304
chr_2 g8333 g8333.t1 cds g8333.t1.CDS5 29798822 29800304
chr_2 g8333 g8333.t1 exon g8333.t1.exon6 29800369 29800738
chr_2 g8333 g8333.t1 cds g8333.t1.CDS6 29800369 29800738
chr_2 g8333 g8333.t1 exon g8333.t1.exon7 29800894 29801007
chr_2 g8333 g8333.t1 cds g8333.t1.CDS7 29800894 29801007
chr_2 g8333 g8333.t1 exon g8333.t1.exon8 29801129 29801411
chr_2 g8333 g8333.t1 cds g8333.t1.CDS8 29801129 29801411
chr_2 g8333 g8333.t1 exon g8333.t1.exon9 29801468 29801732
chr_2 g8333 g8333.t1 cds g8333.t1.CDS9 29801468 29801732
chr_2 g8333 g8333.t1 exon g8333.t1.exon10 29801806 29802442
chr_2 g8333 g8333.t1 cds g8333.t1.CDS10 29801806 29802442
chr_2 g8333 g8333.t1 exon g8333.t1.exon11 29802503 29802689
chr_2 g8333 g8333.t1 cds g8333.t1.CDS11 29802503 29802689
chr_2 g8333 g8333.t1 TTS g8333.t1 29802830 29802830

Sequences

>g8333.t1 Gene=g8333 Length=4329
ATGAGCACTCGTGGAGCAGATGATGCTATAGAGCATCATCTTGTTAATACAGACTCAAGT
AGTGACATACATAAAGGTGCAAGTTCGACAAAAGGTGCATCAATCAAGGAAGTATGTCTA
ATTATAGATTTAAACGAGACCCAAGAGAATTATCAACATCGAAAAATGGCTTACGAAGAA
GTTAAACTTGCATGTCAATCAATTGCATCTAATTTGCAATTGGTACAATTTGGAAAACTT
GATTTTGGCGATACAAGGACGGCTGATATATTTCATAGTGCTGATGTTGCCATTGTTGAT
CTTTCTTTACAACATCAACAAAGTGCCTTATCATATAATTTGGGTCTTCGTGAAAGCTTT
GAAATGAAAAATAATATTGTTCTTTTTAATGATTTAGATCAAGAAGCTACATTGAGATTA
AAAATATCAACTTCTAATTACACATTTTTACCATATCGTCTTTCTGAAGAGAAAAATTCG
TGCATCATTACAAATCCAGTAAAAAGGGAAGGAGGTGAAGATAATATAGACAGTAGTAAG
CAACAAACTCTTTATCAAAAGATGAAAAAAATTCTTCTTGATGTGGAAATTCAGTCAAAA
GCTCATTTGAAAGAAAAATTTTTGGCTGATTTGCGTGCAATAAGAGAACTTAGTGAGATT
GATGACCAAAAGGAAAAGCTTCGACATTTAAGAAAGCGTCTGGACGATCCGAATGTATTA
TCCGGAGAAGTATTTCAACAGTATATGTATTCGTTACGTGATGTACAAGACTATGATGCT
ATGGTGAATTTAATGAATGACTTACAGACTGTGCCAAGTACACAAAAAGTTATGAATACA
GGGCAAATGTCATATCTTTATGCATTTGCATTAAACCGTAGAAATAAAACAGGTGATCGT
GATAAGGCTCTACAAACTTGTGTTAAAGCACTCGAAAAGAAGCAAAATCATTTCCCTGAT
ATGTTATGTTTATGTGGACGAATTTATAAAGATTTATTTGTTGAATCAAACTATACTGAT
AATGAATCTTTACAAAATGCAATACATTGGTATAGAAAATCATTTGAAGTTCAACCCAAC
GAATATGCCGGGATTAATCTTGCAACATTACTCGTTATTAAAGGAGATTCATTCGGTACA
TCACAAGAACTTCAGCATATTGCCATCATATTAAATTCATTTATTGGGCGACGAGGAGAA
TTATCACAACTCAAAGATTATTGGACTGTAGCGACATTCTTTGAGATATCAGTTCTTGCT
GAAGATTATACTAAAGCATCACAAGCCGCAGAGTGCATGTTCAAATTAAAACCACCAAAT
TGGTATTTAAAATCAACTATAGGCAATATTCAACTTATTAATCAATTTCGTGAAATCAAT
GAAAACGTAGCAATAAGTCCAGAAAGAAAAATATTTGATTTTTGGGTAGAATTTTTCTTA
GAAGCAATTAAAACAGAAGCAGGGACAGATATAAGATTTCCTATTTTGGTTTTTGAACCA
CAAGGGAGTAAAAGTACAAGCAATAATAATGTATATCTTCCATCTTATGTAAATGTGAAT
ATGGATGTTGAAGAAAAATCAATTCAAATCATCAACATGTGCGTAAATCATGAAAAAGAT
AATTGCAAAAAGAAACATGATTTTCTTTTTACGGCTGATCAGATTAAATCAGTGTCATTA
TACAAGCGTGATGAACGGTGTGCATATTTGTATGTGCATCAAAATTCAGATGATTTTCAA
ATGTTTTTCCCATCCGTATTATGTCGTCAAAGTTTTTATGACTTTATTCTTGAAATGACT
AAGGATGGATGCGATAGTTTTGTAAGATTGGATGAAGAGTTTACAGCTGACGATATTAAA
TATGAATACGAGTATGATGAAAACAAAATGAGAGTAGTATTGGGTAAAGGAACTTTCGGA
AGTGTGTTTGCAGCACGTGATATAAATACACAAATGAGAATTGCAATAAAAGAAGTGCCT
GAGAAAATATTCGACGCTGTTCAACCATTGCATGAAGAAATCAAGCTTCATTCACAATTG
AGACATAAAAATATTGTAACCTATTATGGTTCAATCTCTGAAAATGGATATTTTAAAATA
TTCATGGAACAAGTGCCTGGTGGATCTCTTTCTGCGTTACTTCGTTCAAAATGGGGTCCA
TTAAAAGATAATGAAAGCACAATAGCTTTTTATAGTAAACAAATCTTATTGGGTCTGAAA
TATTTGCATGATCAAAAAATCGTTCATCGTGATATAAAAGGAGACAATGTTCTCGTAAAT
ACATACAGTGGTGTAATTAAAATTTCCGATTTTGGGACTTCAAAACGTTTAGCTGGAATA
AATCCTAAGGCAGCTACATTTACTGGAACAGTTAATTTTATGGCCCCAGAAATTATTGAT
CAAGGCGCGCGTGGTTATGGACCACCGGCGGACATTTGGGCATTTGGTTGTACAAATGTC
GAAATGGCAACAGGAAAACCACCTTTCATTGAGCTTGGATCACAAGAAGCTGCAATGTTC
AAGATTGGTTTCTACAAAAAACATCCTGAAATACCAGAAGAAATGTCAACATTGGCAAAA
AAATTTATTTTGAGATGCTTCACTGTAGATGTTGATCAACGTGCAACAGCAGCTCAATTG
CTTGAAGATCCATTTTTATCAGATAAACATAGGCGATCAAGAACTCAAATGATGCCTACA
TCAACTACTAATAACACAGGTCATGTAGATTTTAATAGAAGCTATTCTGTTCCTGCTGAT
CGTTTAGTATCAAAATCATCAAATACAGTAAATCATCAACAGAGTGTATCGGCATGTAAT
ACACCAACAACTCCAGAATTCGAGACACCTAGTTCTCATTTTACATCACCTTCTTCACTA
TCGAAATCCGATCATAAAAAATTGTCTGCCAAAAATCACTTATCACCTATCCAGATACCT
ACCATCAGCACAGTCAGCTCAATAACAACACCATCAGTTGATGCAGTAGAAAATGATTTT
AATGTATCATTTAGAAGAAGTTCTACAGGAGTTCTTCTCTCACCTGAAGTCGATGTGCCA
TCATCAACTTCAAAATTACCAGTTGGTGAAACAAATGAAAGTGATGGATTTTATTTGCTC
AAAAAAGATTCACAACGCCGGCAGACTTTATCAAAAGTACTTTCTCAAGATGAAACGAAA
ATATGCGAAGTGTGGATAGAAAAAATTGCACACGATCGGCCTGAAAAAATAATTGATATT
ACTCATCTCGAAAAACTAATTCGTGCTTTACGCGATTACATCACAGATCAAAAGAAAGAA
TTTCTTAAAAAGGCTTTGAATGAACTTAAAAATGAACTAGATTTCGATCCAACTGCTATA
GATCATCTTCACTATGCTTTATACAAATTTCAAGATGCAGTCATCACAGTACTAAGAAGT
GTTAGTATTAAACCGCATTGGATGTTTGCTCTCGATAATTTAGTTAAAGGCGCAGTTCAT
GCATCACTCATGATCTTATCTCCAGAACTTGGTGCAAATTTAGCTGGTAATGAACGTGAT
TTTGTAGATGGTGATGATGATGAGGTGGAGGATGAACTATCAAATTCAGGAATAAGTACA
GTTAATTCATTGAAAACAAAACATCACTCTATTAAAGATAATTATGATAAACTCTTACTT
GAGCAAGTAAAAGTACTTAAAATTGAAAATACAAAACTTATTAATGAATTATTAGAATCT
CACAAGAGTCTTCAAAGTTTATTAAAATCCAGTGAATGCGGAATGGACGCATTAAAAAAT
GTTTTACAACAATATACAAGCTTAACTAGAAGCTTTGAACGTAGTGCTTCGTATGGCTAT
TTCAGTGATGATCAAAATCTAAGAAAACCTTCGATATCAACTGAAAATAGTCCTACACCA
GAGGATAATGCAGAAAAGTCTATTACAAACGTTAATAGTAGAAAATTAAATTCATCACCA
CTTTTCAAAAACCCAACTCTAAAAACGCCATACAGACAGTGCAATGACATGAAACTGATA
GAGTGGCTTTCTCGCAATAATTTTGATGAAGAGGCAAAGCATCTAATCGCGTTTGCCGAT
TTTACTTATGAGGATCTAATGTATTTCTCAGATAAGGATGATATAAGAAGAATCGGTTTG
AGAGCCGGCACGGAAGTTCGTTTATGGAAATTAGTAAATGCACATCGTAAAAAATTTGGA
ACTTACCATGTTGAATTACAACGTAACATGAACGATTCATTAGTAAATGGTTTCTCGAAT
GATGCAGCGGCAAGCAGCTATGACTCGACTTCAAGCGCAACTAATAGTTCTTATGACTCA
TGTGAATGA

>g8333.t1 Gene=g8333 Length=1442
MSTRGADDAIEHHLVNTDSSSDIHKGASSTKGASIKEVCLIIDLNETQENYQHRKMAYEE
VKLACQSIASNLQLVQFGKLDFGDTRTADIFHSADVAIVDLSLQHQQSALSYNLGLRESF
EMKNNIVLFNDLDQEATLRLKISTSNYTFLPYRLSEEKNSCIITNPVKREGGEDNIDSSK
QQTLYQKMKKILLDVEIQSKAHLKEKFLADLRAIRELSEIDDQKEKLRHLRKRLDDPNVL
SGEVFQQYMYSLRDVQDYDAMVNLMNDLQTVPSTQKVMNTGQMSYLYAFALNRRNKTGDR
DKALQTCVKALEKKQNHFPDMLCLCGRIYKDLFVESNYTDNESLQNAIHWYRKSFEVQPN
EYAGINLATLLVIKGDSFGTSQELQHIAIILNSFIGRRGELSQLKDYWTVATFFEISVLA
EDYTKASQAAECMFKLKPPNWYLKSTIGNIQLINQFREINENVAISPERKIFDFWVEFFL
EAIKTEAGTDIRFPILVFEPQGSKSTSNNNVYLPSYVNVNMDVEEKSIQIINMCVNHEKD
NCKKKHDFLFTADQIKSVSLYKRDERCAYLYVHQNSDDFQMFFPSVLCRQSFYDFILEMT
KDGCDSFVRLDEEFTADDIKYEYEYDENKMRVVLGKGTFGSVFAARDINTQMRIAIKEVP
EKIFDAVQPLHEEIKLHSQLRHKNIVTYYGSISENGYFKIFMEQVPGGSLSALLRSKWGP
LKDNESTIAFYSKQILLGLKYLHDQKIVHRDIKGDNVLVNTYSGVIKISDFGTSKRLAGI
NPKAATFTGTVNFMAPEIIDQGARGYGPPADIWAFGCTNVEMATGKPPFIELGSQEAAMF
KIGFYKKHPEIPEEMSTLAKKFILRCFTVDVDQRATAAQLLEDPFLSDKHRRSRTQMMPT
STTNNTGHVDFNRSYSVPADRLVSKSSNTVNHQQSVSACNTPTTPEFETPSSHFTSPSSL
SKSDHKKLSAKNHLSPIQIPTISTVSSITTPSVDAVENDFNVSFRRSSTGVLLSPEVDVP
SSTSKLPVGETNESDGFYLLKKDSQRRQTLSKVLSQDETKICEVWIEKIAHDRPEKIIDI
THLEKLIRALRDYITDQKKEFLKKALNELKNELDFDPTAIDHLHYALYKFQDAVITVLRS
VSIKPHWMFALDNLVKGAVHASLMILSPELGANLAGNERDFVDGDDDEVEDELSNSGIST
VNSLKTKHHSIKDNYDKLLLEQVKVLKIENTKLINELLESHKSLQSLLKSSECGMDALKN
VLQQYTSLTRSFERSASYGYFSDDQNLRKPSISTENSPTPEDNAEKSITNVNSRKLNSSP
LFKNPTLKTPYRQCNDMKLIEWLSRNNFDEEAKHLIAFADFTYEDLMYFSDKDDIRRIGL
RAGTEVRLWKLVNAHRKKFGTYHVELQRNMNDSLVNGFSNDAAASSYDSTSSATNSSYDS
CE

Protein features from InterProScan

Transcript Database ID Name Start End E.value
10 g8333.t1 CDD cd06624 STKc_ASK 619 886 0.0
9 g8333.t1 Coils Coil Coil 213 233 -
6 g8333.t1 Gene3D G3DSA:1.25.40.10 - 222 383 2.1E-5
7 g8333.t1 Gene3D G3DSA:3.30.200.20 Phosphorylase Kinase; domain 1 608 705 4.0E-32
8 g8333.t1 Gene3D G3DSA:1.10.510.10 Transferase(Phosphotransferase) domain 1 706 887 1.0E-54
14 g8333.t1 MobiDBLite mobidb-lite consensus disorder prediction 890 909 -
15 g8333.t1 MobiDBLite mobidb-lite consensus disorder prediction 924 972 -
16 g8333.t1 MobiDBLite mobidb-lite consensus disorder prediction 924 963 -
17 g8333.t1 MobiDBLite mobidb-lite consensus disorder prediction 1288 1310 -
4 g8333.t1 PANTHER PTHR11584 SERINE/THREONINE PROTEIN KINASE 60 1398 0.0
2 g8333.t1 Pfam PF13281 Domain of unknown function (DUF4071) 110 478 1.3E-154
1 g8333.t1 Pfam PF19039 ASK kinase PH domain 490 600 1.2E-36
3 g8333.t1 Pfam PF00069 Protein kinase domain 633 886 2.1E-61
13 g8333.t1 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 634 657 -
12 g8333.t1 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 747 759 -
18 g8333.t1 ProSiteProfiles PS50011 Protein kinase domain profile. 628 886 47.227
11 g8333.t1 SMART SM00220 serkin_6 628 886 5.6E-88
5 g8333.t1 SUPERFAMILY SSF56112 Protein kinase-like (PK-like) 633 943 1.5E-77

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0000165 MAPK cascade BP
GO:0005524 ATP binding MF
GO:0005515 protein binding MF
GO:0004672 protein kinase activity MF
GO:0006468 protein phosphorylation BP

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values