General information for g8687.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Glutaryl-CoA dehydrogenase, mitochondrial.
Parent gene
- The parent gene g8687 is located on chr_2: 32250287..32251461 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g8687 | g8687.t1 | TSS | g8687.t1 | 32249942 | 32249942 |
| chr_2 | g8687 | g8687.t1 | isoform | g8687.t1 | 32250072 | 32251461 |
| chr_2 | g8687 | g8687.t1 | exon | g8687.t1.exon1 | 32250072 | 32250144 |
| chr_2 | g8687 | g8687.t1 | cds | g8687.t1.CDS1 | 32250072 | 32250144 |
| chr_2 | g8687 | g8687.t1 | exon | g8687.t1.exon2 | 32250205 | 32250225 |
| chr_2 | g8687 | g8687.t1 | cds | g8687.t1.CDS2 | 32250205 | 32250225 |
| chr_2 | g8687 | g8687.t1 | exon | g8687.t1.exon3 | 32250287 | 32251461 |
| chr_2 | g8687 | g8687.t1 | cds | g8687.t1.CDS3 | 32250287 | 32251461 |
| chr_2 | g8687 | g8687.t1 | TTS | g8687.t1 | 32251519 | 32251519 |
Sequences
>g8687.t1 Gene=g8687 Length=1269
ATGTCACAAATTTTAAAACAATTTTCACGAAAGTTGTCACAGCCAAAATTGTATAATAAT
TTTCGAGTTCAAGCATTTGCATCAGCTAAATTTGCTGATTTTAATTGGGAAGATGCATTA
AATTTAAATTCATTATTAACTGATGAAGAAAAAGCTGTAAGAGATTCATTTAATCAATAC
TGCCAATCACAATTACTGCCAAGAGTTACAAAAGCAAATCGAGATGAATTTTTTGATCGT
GAAATTTACAAAGAAATGGGACAATACGGCGCACTAGGATGCACAATTAAAGGCTATGAT
TGTGCGGGAGTTTCAAATGTTGCTTATGGATTAATGGCACGTGAAGTTGAAAGAGTTGAT
TCAGCATACCGCAGTGCATTTTCAGTTCAAAGTAGTTTGGCAATGGGTGCAATTTACATG
TATGGAAATGAAGCACAAAAGCAAAAGTTTTTACCAAAAATGGCTAAGGGTGAATTAGTT
GGATGTTTTGGATTAACAGAACCAAATCATGGCTCAGATATTGGTACAATGGAGACAAAA
GCAAAATTTGATTCAAAAACAAAAACGTTTGTGCTATCTGGCAGTAAAACTTGGATTACA
AACAGTCCAATTGCTGACATTCTCATAATTTGGGCAAGATTTGAAGATGGAAAAGTTCGT
GGATTTATTGTTGAAAGATCTGAAAGTTCACAAGGCTTAGCAACACCAAAAATTGAAGGA
AAATTTTCACTTCGAGCATCAGAAACTGGAATGATTTTAATGGATGATGTGAGAGTTCCT
GAAGAAAATCTTTTACCAAATGCTGTTGGAATGAGTGGGCCTTTTGGATGTTTAAATAAT
GCTCGTTATGGAATTGCATGGGGTGCATTAGGAGCAGCTGAAGCTTGTCTTCATATCGCT
AGGCAATATACTTTAGATCGAAAACAATTTAAAAGACCACTTGCAAATACACAATTAATT
CAAAAGAAATTTGCCGACGCTTTGACAGAAATTAATTTGGGTTTAATGGCAGCATATCAA
GTTGGTCGATTGAAGGACAAAAATCTTCATTGTCCAGATATGATTTCAATGATAAAAAGA
AATAATGCAGGAAAATCTTTGGAAATTGCTCGACAAATGCGAGATGTTTTGGGTGGAAAT
GGAATTGCTGATGAATATCATATTATAAGACATGTGATGAATCTTGAAGCTGTTAATACA
TATGAAGGTACTCATGATATTCATGCATTAATCTTAGGTAAAGCAATTACTGGACTTGCT
GCATTTTAA
>g8687.t1 Gene=g8687 Length=422
MSQILKQFSRKLSQPKLYNNFRVQAFASAKFADFNWEDALNLNSLLTDEEKAVRDSFNQY
CQSQLLPRVTKANRDEFFDREIYKEMGQYGALGCTIKGYDCAGVSNVAYGLMAREVERVD
SAYRSAFSVQSSLAMGAIYMYGNEAQKQKFLPKMAKGELVGCFGLTEPNHGSDIGTMETK
AKFDSKTKTFVLSGSKTWITNSPIADILIIWARFEDGKVRGFIVERSESSQGLATPKIEG
KFSLRASETGMILMDDVRVPEENLLPNAVGMSGPFGCLNNARYGIAWGALGAAEACLHIA
RQYTLDRKQFKRPLANTQLIQKKFADALTEINLGLMAAYQVGRLKDKNLHCPDMISMIKR
NNAGKSLEIARQMRDVLGGNGIADEYHIIRHVMNLEAVNTYEGTHDIHALILGKAITGLA
AF
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g8687.t1 | CDD | cd01151 | GCD | 34 | 422 | 0.0 |
| 8 | g8687.t1 | Gene3D | G3DSA:1.10.540.10 | - | 33 | 159 | 4.8E-35 |
| 9 | g8687.t1 | Gene3D | G3DSA:2.40.110.10 | - | 161 | 269 | 1.0E-32 |
| 10 | g8687.t1 | Gene3D | G3DSA:1.20.140.10 | - | 271 | 422 | 3.0E-40 |
| 4 | g8687.t1 | PANTHER | PTHR42807 | GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL | 23 | 422 | 1.7E-209 |
| 3 | g8687.t1 | Pfam | PF02771 | Acyl-CoA dehydrogenase, N-terminal domain | 47 | 158 | 4.3E-26 |
| 1 | g8687.t1 | Pfam | PF02770 | Acyl-CoA dehydrogenase, middle domain | 162 | 257 | 1.1E-19 |
| 2 | g8687.t1 | Pfam | PF00441 | Acyl-CoA dehydrogenase, C-terminal domain | 276 | 416 | 4.5E-27 |
| 7 | g8687.t1 | ProSitePatterns | PS00073 | Acyl-CoA dehydrogenases signature 2. | 375 | 394 | - |
| 5 | g8687.t1 | SUPERFAMILY | SSF56645 | Acyl-CoA dehydrogenase NM domain-like | 33 | 267 | 1.44E-68 |
| 6 | g8687.t1 | SUPERFAMILY | SSF47203 | Acyl-CoA dehydrogenase C-terminal domain-like | 275 | 419 | 2.26E-39 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors | MF |
| GO:0050660 | flavin adenine dinucleotide binding | MF |
| GO:0003995 | acyl-CoA dehydrogenase activity | MF |
| GO:0055114 | NA | NA |
KEGG
Orthology
- This transcript has been annotated with K00252 (glutaryl-CoA dehydrogenase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
