General information for g8687.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Glutaryl-CoA dehydrogenase, mitochondrial.
Parent gene
- The parent gene g8687 is located on chr_2: 32250287..32251461 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g8687 | g8687.t2 | TSS | g8687.t2 | 32249942 | 32249942 |
| chr_2 | g8687 | g8687.t2 | isoform | g8687.t2 | 32250072 | 32251461 |
| chr_2 | g8687 | g8687.t2 | exon | g8687.t2.exon1 | 32250072 | 32250148 |
| chr_2 | g8687 | g8687.t2 | exon | g8687.t2.exon2 | 32250271 | 32251461 |
| chr_2 | g8687 | g8687.t2 | cds | g8687.t2.CDS1 | 32250448 | 32251461 |
| chr_2 | g8687 | g8687.t2 | TTS | g8687.t2 | 32251519 | 32251519 |
Sequences
>g8687.t2 Gene=g8687 Length=1268
ATGTCACAAATTTTAAAACAATTTTCACGAAAGTTGTCACAGCCAAAATTGTATAATAAT
TTTCGAGTTCAAGGTCATTTCTACCTTAAACAGCTGATTTTAATTGGGAAGATGCATTAA
ATTTAAATTCATTATTAACTGATGAAGAAAAAGCTGTAAGAGATTCATTTAATCAATACT
GCCAATCACAATTACTGCCAAGAGTTACAAAAGCAAATCGAGATGAATTTTTTGATCGTG
AAATTTACAAAGAAATGGGACAATACGGCGCACTAGGATGCACAATTAAAGGCTATGATT
GTGCGGGAGTTTCAAATGTTGCTTATGGATTAATGGCACGTGAAGTTGAAAGAGTTGATT
CAGCATACCGCAGTGCATTTTCAGTTCAAAGTAGTTTGGCAATGGGTGCAATTTACATGT
ATGGAAATGAAGCACAAAAGCAAAAGTTTTTACCAAAAATGGCTAAGGGTGAATTAGTTG
GATGTTTTGGATTAACAGAACCAAATCATGGCTCAGATATTGGTACAATGGAGACAAAAG
CAAAATTTGATTCAAAAACAAAAACGTTTGTGCTATCTGGCAGTAAAACTTGGATTACAA
ACAGTCCAATTGCTGACATTCTCATAATTTGGGCAAGATTTGAAGATGGAAAAGTTCGTG
GATTTATTGTTGAAAGATCTGAAAGTTCACAAGGCTTAGCAACACCAAAAATTGAAGGAA
AATTTTCACTTCGAGCATCAGAAACTGGAATGATTTTAATGGATGATGTGAGAGTTCCTG
AAGAAAATCTTTTACCAAATGCTGTTGGAATGAGTGGGCCTTTTGGATGTTTAAATAATG
CTCGTTATGGAATTGCATGGGGTGCATTAGGAGCAGCTGAAGCTTGTCTTCATATCGCTA
GGCAATATACTTTAGATCGAAAACAATTTAAAAGACCACTTGCAAATACACAATTAATTC
AAAAGAAATTTGCCGACGCTTTGACAGAAATTAATTTGGGTTTAATGGCAGCATATCAAG
TTGGTCGATTGAAGGACAAAAATCTTCATTGTCCAGATATGATTTCAATGATAAAAAGAA
ATAATGCAGGAAAATCTTTGGAAATTGCTCGACAAATGCGAGATGTTTTGGGTGGAAATG
GAATTGCTGATGAATATCATATTATAAGACATGTGATGAATCTTGAAGCTGTTAATACAT
ATGAAGGTACTCATGATATTCATGCATTAATCTTAGGTAAAGCAATTACTGGACTTGCTG
CATTTTAA
>g8687.t2 Gene=g8687 Length=337
MGQYGALGCTIKGYDCAGVSNVAYGLMAREVERVDSAYRSAFSVQSSLAMGAIYMYGNEA
QKQKFLPKMAKGELVGCFGLTEPNHGSDIGTMETKAKFDSKTKTFVLSGSKTWITNSPIA
DILIIWARFEDGKVRGFIVERSESSQGLATPKIEGKFSLRASETGMILMDDVRVPEENLL
PNAVGMSGPFGCLNNARYGIAWGALGAAEACLHIARQYTLDRKQFKRPLANTQLIQKKFA
DALTEINLGLMAAYQVGRLKDKNLHCPDMISMIKRNNAGKSLEIARQMRDVLGGNGIADE
YHIIRHVMNLEAVNTYEGTHDIHALILGKAITGLAAF
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g8687.t2 | Gene3D | G3DSA:1.10.540.10 | - | 1 | 74 | 3.6E-19 |
| 9 | g8687.t2 | Gene3D | G3DSA:2.40.110.10 | - | 76 | 184 | 6.5E-33 |
| 10 | g8687.t2 | Gene3D | G3DSA:1.20.140.10 | - | 186 | 337 | 1.8E-40 |
| 4 | g8687.t2 | PANTHER | PTHR42807 | GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL | 1 | 337 | 1.5E-186 |
| 3 | g8687.t2 | Pfam | PF02771 | Acyl-CoA dehydrogenase, N-terminal domain | 1 | 73 | 4.8E-16 |
| 1 | g8687.t2 | Pfam | PF02770 | Acyl-CoA dehydrogenase, middle domain | 77 | 172 | 7.3E-20 |
| 2 | g8687.t2 | Pfam | PF00441 | Acyl-CoA dehydrogenase, C-terminal domain | 191 | 331 | 2.7E-27 |
| 7 | g8687.t2 | ProSitePatterns | PS00073 | Acyl-CoA dehydrogenases signature 2. | 290 | 309 | - |
| 5 | g8687.t2 | SUPERFAMILY | SSF56645 | Acyl-CoA dehydrogenase NM domain-like | 1 | 182 | 1.44E-56 |
| 6 | g8687.t2 | SUPERFAMILY | SSF47203 | Acyl-CoA dehydrogenase C-terminal domain-like | 190 | 334 | 1.35E-39 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors | MF |
| GO:0050660 | flavin adenine dinucleotide binding | MF |
| GO:0003995 | acyl-CoA dehydrogenase activity | MF |
| GO:0055114 | NA | NA |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
