Gene loci information

Transcript annotation

  • This transcript has been annotated as Serine/threonine-protein kinase TBK1.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_2 g8847 g8847.t1 TTS g8847.t1 33499336 33499336
chr_2 g8847 g8847.t1 isoform g8847.t1 33499625 33502036
chr_2 g8847 g8847.t1 exon g8847.t1.exon1 33499625 33499744
chr_2 g8847 g8847.t1 cds g8847.t1.CDS1 33499625 33499744
chr_2 g8847 g8847.t1 exon g8847.t1.exon2 33499807 33500118
chr_2 g8847 g8847.t1 cds g8847.t1.CDS2 33499807 33500118
chr_2 g8847 g8847.t1 exon g8847.t1.exon3 33500185 33501898
chr_2 g8847 g8847.t1 cds g8847.t1.CDS3 33500185 33501898
chr_2 g8847 g8847.t1 exon g8847.t1.exon4 33501981 33502036
chr_2 g8847 g8847.t1 cds g8847.t1.CDS4 33501981 33502036
chr_2 g8847 g8847.t1 TSS g8847.t1 33502151 33502151

Sequences

>g8847.t1 Gene=g8847 Length=2202
ATGTCATTTCTACGAGGATCTCTTAATTATGTGTGGTGCACAACGAGTGTTTTAGGCAAA
GGGGCAACTGGAGCAGTTTTTCAAGGCGTCAATAAACATAATGGCGAACCAGTGGCTGTC
AAGACTTTCAATCAATTGTCACATATGCGACCTTATGAAGTTCAAATGCGAGAATTTGAA
GTGCTACGGAAAGTGAAGCATGATAACATAGTAAAATTGCTTGCAATTGAAGATGATCAA
GAAGGACGTGGAAAAGTAATTGTGATGGAATTGTGCACTGGTGGAAGTTTATTTAACATT
TTAGATGATCCAGAAAATACTTATGGCCTTGCACAGCATGAATTTTTACTTGTTCTTGAA
CATTTGACAGCTGGAATGAAACATCTTCGTGATAATAATCTTGTACATCGTGATCTCAAG
CCTGGAAATATTATGCGATACATTTCCGAAGAAGGCTTAACAATTTATAAACTTACAGAT
TTTGGAGCTGCTAGAGAATTAGAAGAAAATCAACAATTTATGTCACTTTATGGCACAGAA
GAATATTTACATCCTGACATGTATGAACGTGCTGTATTAAGAAAATCAGTTAATCGTTCA
TTTACAGCAAATGTTGACCTTTGGTCGATTGGGGTAACACTTTACCATATTGCGACAGGT
AATTTGCCATTCAGACCATATGGTGGACGAAAGAACAAAGAAACAATGCATCATATAACA
ACGAAAAAATTGTCTGGTGTGATTTCTGGAATTCAAACAACAGAGAATGGTCCAATTGAA
TGGTCACGTCATTTACCTGACCATTGTCAACTCTCAACAGGTCTTAAATATCTTGTTACA
CCACTACTTGCTGGATTATTAGAGGAAAATCAAAAACGAATGTGGAGTTTTGAAAGATTT
TTCAATGAAGTCACAAATATACTTAATAAAAAAGTTATTCATTTATTTTACATGAATAGA
GCTTCATCGATTGAAGTTTTTATGGATTCAGAAGAGGCTAATACACTGTTTCATTTTAAA
GAGCATGTGAATTTACAAACAGATGTTAATCCTGACAGTCAATTATTATTATTTGATGAA
GAACATATGGAAGAGAAAGTTGGTGCAAATACTTCAGTTCGTGGTTATCCACCAACAACA
ACATTAAAGCCAATAATGTTATTTAGTGTAGAAAACAACAATGTTTCATTGCCTAAAGAA
TTGGAATTACCTAAGTTTCCGAATTTTCCAGCAGGTGTGAGTGTTGAAAATGATGCAAGT
TTGGCAAAAGTTGCATGCTCAGTTGGTCATGAATGCAAAAGAAGAATTGAAAGCTTTAGT
CGCATTGATATGTTGATGAATGCAGGTATTGAGAGACTCGTTGGATTACTTAGAGCCACT
TTGAATAAATTATTAGAAAAATCAAAAAATTTTGAAGACATTCACAGCACAATTCATGAA
TTGGCAGAAACACTTGAGTTGTTGGTTACAAATGAGATTTATCATGATGAAGCAAAACAA
ATTGGAATGGAATTAAATAGTTTAAAAGATGATTTTACAAGAGTTTCTGAACCAATTCAA
CAATTGTATAATAGATTTTGTATTGAAGATCAACTGACTCGTGAATGGAAGACAAGCTCG
AGGGATATCAAAGGCCCATCGAAAAATTATTCCAATGAAAAAGCAAAACATTTAGTTGAA
AGATTGAGAGATTCTTGGCAACATTTGTTACGTGATAGAGCCACAAGAAGTCTGACTTAT
AATGATGAACAATTTCATGCCTTAGAAAAGATAAAAATAGCAGAAACAGGGAAAAGAATT
AAAGCCTTATTAAATGACAATGTTAAACCAGCAATAGCAATGGAAGCTGAATGTTTAGCT
GATTGGTATAAAATGGCGCAAACTATTTATTTGCAAACGCAAATTTTAGAAAAGGATTTA
TCAAGTTACGAAGAAACAATTTTTGAATTACGAGACAGATTGGTTAGAATTAAAGAAGAA
CTCAAGACGGAAAATAATGATCCGAAGAAGAATGTTTCATGCATGTTCAAAGAATCATCG
ATGGCAGTTAGAAAAAGATTTGAAATTTCAAGTGATGTTAAGAATATGCTTGAATATCAA
AAAGAAATTCAAAGTATTCTACAAGAAAATGCAGAGTTGATCAAAATGGCTCAAAATATT
CCTTTTGATGATGGGAATTCAATAGAAAATAGTCATTTATAG

>g8847.t1 Gene=g8847 Length=733
MSFLRGSLNYVWCTTSVLGKGATGAVFQGVNKHNGEPVAVKTFNQLSHMRPYEVQMREFE
VLRKVKHDNIVKLLAIEDDQEGRGKVIVMELCTGGSLFNILDDPENTYGLAQHEFLLVLE
HLTAGMKHLRDNNLVHRDLKPGNIMRYISEEGLTIYKLTDFGAARELEENQQFMSLYGTE
EYLHPDMYERAVLRKSVNRSFTANVDLWSIGVTLYHIATGNLPFRPYGGRKNKETMHHIT
TKKLSGVISGIQTTENGPIEWSRHLPDHCQLSTGLKYLVTPLLAGLLEENQKRMWSFERF
FNEVTNILNKKVIHLFYMNRASSIEVFMDSEEANTLFHFKEHVNLQTDVNPDSQLLLFDE
EHMEEKVGANTSVRGYPPTTTLKPIMLFSVENNNVSLPKELELPKFPNFPAGVSVENDAS
LAKVACSVGHECKRRIESFSRIDMLMNAGIERLVGLLRATLNKLLEKSKNFEDIHSTIHE
LAETLELLVTNEIYHDEAKQIGMELNSLKDDFTRVSEPIQQLYNRFCIEDQLTREWKTSS
RDIKGPSKNYSNEKAKHLVERLRDSWQHLLRDRATRSLTYNDEQFHALEKIKIAETGKRI
KALLNDNVKPAIAMEAECLADWYKMAQTIYLQTQILEKDLSSYEETIFELRDRLVRIKEE
LKTENNDPKKNVSCMFKESSMAVRKRFEISSDVKNMLEYQKEIQSILQENAELIKMAQNI
PFDDGNSIENSHL

Protein features from InterProScan

Transcript Database ID Name Start End E.value
13 g8847.t1 CDD cd12219 Ubl_TBK1_like 310 389 3.33115E-18
12 g8847.t1 Coils Coil Coil 640 667 -
11 g8847.t1 Coils Coil Coil 696 716 -
8 g8847.t1 Gene3D G3DSA:3.30.200.20 Phosphorylase Kinase; domain 1 4 91 4.3E-26
10 g8847.t1 Gene3D G3DSA:1.10.510.10 Transferase(Phosphotransferase) domain 1 92 314 2.0E-52
7 g8847.t1 Gene3D G3DSA:3.10.20.90 - 315 398 7.0E-19
9 g8847.t1 Gene3D G3DSA:1.20.1270.420 - 413 660 3.3E-36
4 g8847.t1 PANTHER PTHR22969 IKB KINASE 2 715 5.1E-262
5 g8847.t1 PANTHER PTHR22969:SF15 FI05319P-RELATED 2 715 5.1E-262
3 g8847.t1 Pfam PF00069 Protein kinase domain 16 293 1.1E-44
2 g8847.t1 Pfam PF18396 TANK binding kinase 1 ubiquitin-like domain 310 395 9.0E-17
1 g8847.t1 Pfam PF18394 TANK-binding kinase 1 coiled-coil domain 1 407 658 2.3E-61
14 g8847.t1 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 18 41 -
16 g8847.t1 ProSiteProfiles PS50011 Protein kinase domain profile. 12 317 38.209
15 g8847.t1 SMART SM00220 serkin_6 12 313 1.9E-35
6 g8847.t1 SUPERFAMILY SSF56112 Protein kinase-like (PK-like) 14 307 1.25E-51

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0005524 ATP binding MF
GO:0004672 protein kinase activity MF
GO:0006468 protein phosphorylation BP

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values