General information for g8992.t6
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Signal transducer and activator of transcription 5A.
Parent gene
- The parent gene g8992 is located on chr_2: 34418374..34420073 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g8992 | g8992.t6 | TSS | g8992.t6 | 34411271 | 34411271 |
| chr_2 | g8992 | g8992.t6 | isoform | g8992.t6 | 34411351 | 34414010 |
| chr_2 | g8992 | g8992.t6 | exon | g8992.t6.exon1 | 34411351 | 34411368 |
| chr_2 | g8992 | g8992.t6 | exon | g8992.t6.exon2 | 34412296 | 34412439 |
| chr_2 | g8992 | g8992.t6 | cds | g8992.t6.CDS1 | 34412312 | 34412439 |
| chr_2 | g8992 | g8992.t6 | exon | g8992.t6.exon3 | 34412556 | 34413187 |
| chr_2 | g8992 | g8992.t6 | cds | g8992.t6.CDS2 | 34412556 | 34413187 |
| chr_2 | g8992 | g8992.t6 | exon | g8992.t6.exon4 | 34413276 | 34413528 |
| chr_2 | g8992 | g8992.t6 | cds | g8992.t6.CDS3 | 34413276 | 34413528 |
| chr_2 | g8992 | g8992.t6 | exon | g8992.t6.exon5 | 34413833 | 34414010 |
| chr_2 | g8992 | g8992.t6 | cds | g8992.t6.CDS4 | 34413833 | 34414010 |
| chr_2 | g8992 | g8992.t6 | TTS | g8992.t6 | NA | NA |
Sequences
>g8992.t6 Gene=g8992 Length=1225
GTGCATTTGGTAGAAAAGAAAGTGATATATAATAATGGCTTTGTGGAACAAGTTGCTGCA
ATCGCGGCCTGAAGTGATGGAGCAAATTCGTGTATCCTATGGAAACCATTTCCCCATGGA
AGTTCGTCATTACCTATGCGATTGGCTTGAATCGAGACTACTTTCCGGTCCAATGGTTTT
AGATCATGATCCACAGTTGGAAATTGAATCTGCACGCTTTCTTAATGAACTACTTATTGA
ACTTGAAAGAAAAGCTAACGAAATGAGTTCAGATGAGCTAATTACCGCGAAATTACGTTT
ATTAGAATCAGCGAAAAATTTCCGTCAATTATTTTCACACAATCCGAGTCAGCTGTATTC
ACATCTTCGTAATTGTCTGATGTTTGAAAAAAATATGCTCTGTTATCCTGAGGAATGTGG
TGTTACACAAAACAGTGAGTTTACGCAAATTTTTCAAGCCCTTGAGGAACTTGTTTCACG
TATTCGCGCCAATGAGAATGAAAATCGTAATTTGAAGAAGCGTTATGAGATTTTCTGCTG
TGAACTGCATGAAGTTACCAAAAACAATGCACAATATGATATACTTGATACTCAAAATCC
TGAACATCGTGAAAGAATTGCACAATTGAGACGTGAATCACAAGAGAAATTGCAATTGTC
ATTAAATCAACTGACTGGAATGCGATTGAATCTTGTTGATAAATTTAAGGCAACAATCGA
GCTTAGTGAGACTGTACAACAGAAAGTTATCGACAAGTACTTAAATCAATGGCGTATGAA
TCAAGGATTAGCTGCACCACCGTCAAATGCCAATAATCTCGACATCATTCAAGGCTGGTG
TGAACATCTTGCTGACATTTTATGGAATACACGCGAGCAAATTAAAATGGTCTCTAAATA
TCGCAAACAAGTGAATGTTGATGAGCAAAGTTTACCAGACTTTTTGCCCGAACTTTTTGC
TAAAGTCACTGGTCTACTTGAACATTTGATTACACGTTCGTTTATCATTGAAAAACAACC
ACCGCAAGTTATGAAAACAAATACAAGATTCGCATCAACAGTTCGTTTATTAATTGGAAA
TACTTTGAATATTAAAATGAATAGTCCACTAGTAAAGGTAACAATCGTATCGGAACAACA
GGCACAACAAACACAGCAGACAAATAAATGCTCAGAGCACACGTGTGGTGAAATCCTAAA
TAGCACTGGAAATATGGAATATAAT
>g8992.t6 Gene=g8992 Length=397
MALWNKLLQSRPEVMEQIRVSYGNHFPMEVRHYLCDWLESRLLSGPMVLDHDPQLEIESA
RFLNELLIELERKANEMSSDELITAKLRLLESAKNFRQLFSHNPSQLYSHLRNCLMFEKN
MLCYPEECGVTQNSEFTQIFQALEELVSRIRANENENRNLKKRYEIFCCELHEVTKNNAQ
YDILDTQNPEHRERIAQLRRESQEKLQLSLNQLTGMRLNLVDKFKATIELSETVQQKVID
KYLNQWRMNQGLAAPPSNANNLDIIQGWCEHLADILWNTREQIKMVSKYRKQVNVDEQSL
PDFLPELFAKVTGLLEHLITRSFIIEKQPPQVMKTNTRFASTVRLLIGNTLNIKMNSPLV
KVTIVSEQQAQQTQQTNKCSEHTCGEILNSTGNMEYN
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 14 | g8992.t6 | Coils | Coil | Coil | 60 | 80 | - |
| 15 | g8992.t6 | Coils | Coil | Coil | 143 | 163 | - |
| 13 | g8992.t6 | Coils | Coil | Coil | 181 | 201 | - |
| 11 | g8992.t6 | Gene3D | G3DSA:1.10.532.10 | Transcription Factor | 1 | 130 | 5.9E-33 |
| 12 | g8992.t6 | Gene3D | G3DSA:1.20.1050.20 | - | 131 | 323 | 1.3E-44 |
| 10 | g8992.t6 | Gene3D | G3DSA:2.60.40.630 | - | 324 | 397 | 1.6E-24 |
| 4 | g8992.t6 | PANTHER | PTHR11801 | SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION | 1 | 396 | 1.2E-60 |
| 5 | g8992.t6 | PANTHER | PTHR11801:SF47 | SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A | 1 | 396 | 1.2E-60 |
| 1 | g8992.t6 | Pfam | PF02865 | STAT protein, protein interaction domain | 2 | 123 | 3.5E-28 |
| 2 | g8992.t6 | Pfam | PF01017 | STAT protein, all-alpha domain | 138 | 315 | 2.8E-32 |
| 3 | g8992.t6 | Pfam | PF02864 | STAT protein, DNA binding domain | 327 | 397 | 3.2E-20 |
| 9 | g8992.t6 | SMART | SM00964 | STAT_int_2 | 2 | 128 | 3.5E-28 |
| 7 | g8992.t6 | SUPERFAMILY | SSF48092 | Transcription factor STAT-4 N-domain | 1 | 125 | 2.75E-24 |
| 6 | g8992.t6 | SUPERFAMILY | SSF47655 | STAT | 134 | 323 | 1.69E-35 |
| 8 | g8992.t6 | SUPERFAMILY | SSF49417 | p53-like transcription factors | 318 | 397 | 3.15E-16 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0042025 | host cell nucleus | CC |
| GO:0003677 | DNA binding | MF |
| GO:0007165 | signal transduction | BP |
| GO:0006355 | regulation of transcription, DNA-templated | BP |
| GO:0060397 | growth hormone receptor signaling pathway via JAK-STAT | BP |
| GO:0003700 | DNA-binding transcription factor activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
