General information for g9675.t6
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as 5-aminolevulinate synthase, erythroid-specific, mitochondrial.
Parent gene
- The parent gene g9675 is located on chr_1: 4538494..4544251 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g9675 | g9675.t6 | TTS | g9675.t6 | 4537617 | 4537617 |
| chr_1 | g9675 | g9675.t6 | isoform | g9675.t6 | 4537956 | 4539536 |
| chr_1 | g9675 | g9675.t6 | exon | g9675.t6.exon1 | 4537956 | 4539536 |
| chr_1 | g9675 | g9675.t6 | cds | g9675.t6.CDS1 | 4537956 | 4539485 |
| chr_1 | g9675 | g9675.t6 | TSS | g9675.t6 | 4539997 | 4539997 |
Sequences
>g9675.t6 Gene=g9675 Length=1581
AATCAACTTGTTAAATCAACTTCAAGCCTAATCCGCACGGTGAGCAGCAAAATGCCTTGC
CCATTTTTGACGCGTTTGAGTTCAACTTATGTCCGCAATTATGCACCAATCCTTATGAAG
ACCTACGGCAATCAATGCCCTGTCGTTGCTCGTGCAATTTCTCAATTGCAAAATGCCGCT
GGTGCTACAACTATCCAAAATCAAGACCGTAAATTGAGCTCAACTCAAACTGAACCAATT
GCTGAGAATCAATGCCAAGCGCCACCATCATTGGCTGAAGTTGATTCGCATTTGAAAGAA
GTTAATGAAGCTCTTTTGCAAGATATTCCACAAAATCGCGAATCACAACCACTTTTTGCT
TATGAAGATTTCTTTCATGAACAAATCATGAAGAAAAAGCGTGATCATTCATATCGTGTG
TTCAAGAAAGTCAATCGTTTAGCTGGTCCTGGACAATTCCCAAAAGGTCTCGAATATGGC
AATCGTCCAATTACTGTTTGGTGTTCAAACGACTACTTAGGCATGTCATCGCATCCTGAA
GTTAAAAATGCCGTGCATGAAGCCTTAGAAAAATACGGCGCTGGTGCTGGAGGTACCCGT
AACATTTCTGGAAATTCCATGATGCATGAAGCACTTGAAAAGCAATTGGCTGGCTTACAT
CAAAAGGAAGCAGCACTTGTCTTCTCATCATGCTATGTGGCAAATGATTCAACTCTTTTC
ACTCTCGCTAAATTGCTACCTGGTTGTCATATCTTTTCTGATGCTGGAAATCACGCTTCA
ATGATTCAAGGCATAAGAAATAGTGGTGTGCCAAAGCACATCTTTCGGCATAATGATCCT
GATCATTTACGCGAACTTATCTCGAAAATTCCGAAAGAAGTGCCAAAAATTGTTGCTTTC
GAGACTGTGCATAGCATGACTGGCGCTGTCTGCCCTTTGGAAGAACTCTGTGATATCGCT
CATGAACATGGTGCTATTACATTTGTCGATGAAGTTCATGCCGTAGGTCTCTATGGTGAA
CATGGTGCTGGAATTGGTGAACGTGATGGTATGATGCATAAAATGGACATTATTTCGGGA
ACTTTGGGAAAAGCTTTTGGAAATGTTGGCGGATATATTGCATCGACAAGTAATTTGGTT
GATATGATTCGCTCTTATGCTGCTGGTTTTATTTTCACCACTTCGTTACCACCGACTGTC
TTGTGTGGTGCATCTAAAGCTGTTGAAGTTCTTGCATCAGAAGAAGGTCGTCAACTTCGT
GAAAAACATCAATCAAATGTTCGCTATTTACGCAATAAGTTGAAGGCTGAAGGTTTCCCA
GTTGAACACACTCCATCACATATCATTCCAGTTAAAATTGGCAATCCTAAACATAGCACT
GCTATTTCTGATATGTTGATTCAGGAATATGGTCATTATATACAAGCTATCAACTATCCA
ACTGTTGCTCGTGGTGATGAAAAACTTCGTTTGGCTCCAACTCCTTATCACGTCCCAGAA
ATGGCTGATGTTCTTGTTGCTGACATGAAAGAAGTCTGGAAGAAACTTGGACTGCAATTA
AAGGGCATGCAATGCTCAAAG
>g9675.t6 Gene=g9675 Length=510
MPCPFLTRLSSTYVRNYAPILMKTYGNQCPVVARAISQLQNAAGATTIQNQDRKLSSTQT
EPIAENQCQAPPSLAEVDSHLKEVNEALLQDIPQNRESQPLFAYEDFFHEQIMKKKRDHS
YRVFKKVNRLAGPGQFPKGLEYGNRPITVWCSNDYLGMSSHPEVKNAVHEALEKYGAGAG
GTRNISGNSMMHEALEKQLAGLHQKEAALVFSSCYVANDSTLFTLAKLLPGCHIFSDAGN
HASMIQGIRNSGVPKHIFRHNDPDHLRELISKIPKEVPKIVAFETVHSMTGAVCPLEELC
DIAHEHGAITFVDEVHAVGLYGEHGAGIGERDGMMHKMDIISGTLGKAFGNVGGYIASTS
NLVDMIRSYAAGFIFTTSLPPTVLCGASKAVEVLASEEGRQLREKHQSNVRYLRNKLKAE
GFPVEHTPSHIIPVKIGNPKHSTAISDMLIQEYGHYIQAINYPTVARGDEKLRLAPTPYH
VPEMADVLVADMKEVWKKLGLQLKGMQCSK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g9675.t6 | CDD | cd06454 | KBL_like | 145 | 496 | 0 |
| 5 | g9675.t6 | Gene3D | G3DSA:3.90.1150.10 | Aspartate Aminotransferase | 114 | 489 | 0 |
| 6 | g9675.t6 | Gene3D | G3DSA:3.40.640.10 | - | 162 | 397 | 0 |
| 2 | g9675.t6 | PANTHER | PTHR13693:SF57 | 5-AMINOLEVULINATE SYNTHASE | 49 | 504 | 0 |
| 3 | g9675.t6 | PANTHER | PTHR13693 | CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE | 49 | 504 | 0 |
| 1 | g9675.t6 | Pfam | PF00155 | Aminotransferase class I and II | 147 | 489 | 0 |
| 4 | g9675.t6 | SUPERFAMILY | SSF53383 | PLP-dependent transferases | 102 | 500 | 0 |
| 7 | g9675.t6 | TIGRFAM | TIGR01821 | 5aminolev_synth: 5-aminolevulinic acid synthase | 103 | 503 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0009058 | biosynthetic process | BP |
| GO:0033014 | tetrapyrrole biosynthetic process | BP |
| GO:0003870 | 5-aminolevulinate synthase activity | MF |
| GO:0003824 | catalytic activity | MF |
| GO:0030170 | pyridoxal phosphate binding | MF |
KEGG
Orthology
- This transcript has been annotated with K00643 (5-aminolevulinate synthase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
