General information for g986.t4
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Angiotensin-converting enzyme.
Parent gene
- The parent gene g986 is located on chr_3: 7264712..7265470 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g986 | g986.t4 | isoform | g986.t4 | 7262017 | 7264903 |
| chr_3 | g986 | g986.t4 | exon | g986.t4.exon1 | 7262017 | 7262357 |
| chr_3 | g986 | g986.t4 | exon | g986.t4.exon2 | 7262416 | 7262664 |
| chr_3 | g986 | g986.t4 | cds | g986.t4.CDS1 | 7262559 | 7262664 |
| chr_3 | g986 | g986.t4 | exon | g986.t4.exon3 | 7262748 | 7262972 |
| chr_3 | g986 | g986.t4 | cds | g986.t4.CDS2 | 7262748 | 7262972 |
| chr_3 | g986 | g986.t4 | exon | g986.t4.exon4 | 7263029 | 7263221 |
| chr_3 | g986 | g986.t4 | cds | g986.t4.CDS3 | 7263029 | 7263221 |
| chr_3 | g986 | g986.t4 | exon | g986.t4.exon5 | 7263273 | 7263369 |
| chr_3 | g986 | g986.t4 | cds | g986.t4.CDS4 | 7263273 | 7263369 |
| chr_3 | g986 | g986.t4 | exon | g986.t4.exon6 | 7263429 | 7263749 |
| chr_3 | g986 | g986.t4 | cds | g986.t4.CDS5 | 7263429 | 7263749 |
| chr_3 | g986 | g986.t4 | exon | g986.t4.exon7 | 7264712 | 7264903 |
| chr_3 | g986 | g986.t4 | cds | g986.t4.CDS6 | 7264712 | 7264897 |
| chr_3 | g986 | g986.t4 | TSS | g986.t4 | 7265656 | 7265656 |
| chr_3 | g986 | g986.t4 | TTS | g986.t4 | NA | NA |
Sequences
>g986.t4 Gene=g986 Length=1618
ATAAAAATGTTGATGTTTTTGCAAATAATTGCGGTTGCATTAGTCAGTGTTAATGCACAA
TTAACAGAAGAACAAATGTTACAGCATTTAGAAGAATATGACAATAAAACAAAACTACTA
TGCAATGCACAAGCTAAAGCCAATTGGGCAGTTCAAACTGATGTTGGAAATCTAACTAAA
GAAGCGGCTCAGGCTGAAGCTATTTTGGCTTATTCATCTTATAGACAAGAGCAATATGAA
ACAATTTTCAAAAATGCACCATCTTATTCAAATGAAGACATCACAAGAAAACTTAAATTG
CTTAAAGAAGTTGGAACTGCAGCTTTATCAGCAGATGATTTAAGAAATTTAACAGCAACA
AGAACAAGAATGTCGAAAATTTACAATTCAGCTAAAATTTGTCCATTCGATAACCAAAAT
TGTAATAAAACTACTCAAGGAATGTTTTTAGATCCAAATATTGAATTAGCTCTTGCAAAA
TCAACAAATTATGATGAATTGCAGTATCTTTGGGAAAAATGGCGTGATGAATCAGGAAAA
TTGATGAGAGATGACTATAAAACTTATATTGATTTATATAATAAAGCTGCACAACTTAAT
GGATATTCAGATGCTGGTGCAATGTGGAGAGGACGATATGAAGAAGAACGATTGGTTGAA
ATTGTCGATGAATTATGGGCTGAAGTTGAGCCGCTCTATAACGAACTTCATACTTACGTT
CGATATAAATTGCTTGAAATTTATGGTGATAAAATGGACAAATATGATCCATTGATTCCA
GCTCACGTTTTTGGTAACATGTGGGCACAAAATTGGGTTCATTTATATGAAAGAATTAAA
CCATTCAAAAATGCTTCATCAGTTGATGTCACAAAAAATATGGAAGAAATGAATATGACT
GTCTATAAAATGTTTGAACTTAGTGATGAATTTTATATGAGTATGGGATTACCAACAAGT
AACATGAGTTACACAGGAGAATCAGTGATTGAAAGAATTCCAGGAGTTAATATGGCTTGT
CATGCTAGTGCTTGGGATTTCTGTGATGGTGAAGATTTCCGTATAAAAATGTGCACAAAA
ATTAATCAAGAAGATTTTATAGTTGTTCATCATGAGATGGGTCATATTATGTAAGATTTA
GGACATTTAATTTTAAACTTTCTGTAACTAATAGAAATTATGAATTTTTAGGTACTATTT
ATTGTACAAAGATTTGCCATTGATTTATAGAGGGGGTGCAAATCCAGGTTTCCATGAAGC
TATTGGCGATACAATTGCTCTTTCGGTTTCAACACCAAAACATTTGGAGAAAGTTGGTCT
TTTAAGTGGTTACCAAAACAGTGAGGCTGACAATATCAACGCACTTTTCCATATGGCACT
CGAACGTGTTGCTTTCCTTCCATTTGGTTTGTTGATTGATAAATGGCGTTGGGACTTATT
TAGTGGTGCAACACCTGAATCTGAATGGAATAAACATTGGTGGGAACTACGAGAAAAATA
CCAAAAAATTCGAGCACCATCACCTCGTGGTGAAGAATTTTTCGATCCAGGCGCAAAATA
TCACATTCCAGCTGATTCACAATACATTGCATATTTTGTTGCTCATATTTTGGAATTT
>g986.t4 Gene=g986 Length=375
MLMFLQIIAVALVSVNAQLTEEQMLQHLEEYDNKTKLLCNAQAKANWAVQTDVGNLTKEA
AQAEAILAYSSYRQEQYETIFKNAPSYSNEDITRKLKLLKEVGTAALSADDLRNLTATRT
RMSKIYNSAKICPFDNQNCNKTTQGMFLDPNIELALAKSTNYDELQYLWEKWRDESGKLM
RDDYKTYIDLYNKAAQLNGYSDAGAMWRGRYEEERLVEIVDELWAEVEPLYNELHTYVRY
KLLEIYGDKMDKYDPLIPAHVFGNMWAQNWVHLYERIKPFKNASSVDVTKNMEEMNMTVY
KMFELSDEFYMSMGLPTSNMSYTGESVIERIPGVNMACHASAWDFCDGEDFRIKMCTKIN
QEDFIVVHHEMGHIM
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 14 | g986.t4 | CDD | cd06461 | M2_ACE | 28 | 374 | 6.01855E-152 |
| 2 | g986.t4 | PANTHER | PTHR10514 | ANGIOTENSIN-CONVERTING ENZYME | 10 | 374 | 3.7E-121 |
| 4 | g986.t4 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 220 | 247 | 3.2E-29 |
| 3 | g986.t4 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 255 | 276 | 3.2E-29 |
| 5 | g986.t4 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 332 | 357 | 3.2E-29 |
| 6 | g986.t4 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 364 | 375 | 3.2E-29 |
| 1 | g986.t4 | Pfam | PF01401 | Angiotensin-converting enzyme | 20 | 374 | 2.5E-104 |
| 10 | g986.t4 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 17 | - |
| 11 | g986.t4 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 1 | - |
| 12 | g986.t4 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 2 | 13 | - |
| 13 | g986.t4 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 14 | 17 | - |
| 9 | g986.t4 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 18 | 375 | - |
| 7 | g986.t4 | SUPERFAMILY | SSF55486 | Metalloproteases (zincins), catalytic domain | 21 | 375 | 3.87E-101 |
| 8 | g986.t4 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 17 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0008241 | peptidyl-dipeptidase activity | MF |
| GO:0008237 | metallopeptidase activity | MF |
| GO:0006508 | proteolysis | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed