General information for g9919.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aurora kinase B.
Parent gene
- The parent gene g9919 is located on chr_1: 6047683..6048752 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g9919 | g9919.t1 | TSS | g9919.t1 | 6046533 | 6046533 |
| chr_1 | g9919 | g9919.t1 | isoform | g9919.t1 | 6046594 | 6047683 |
| chr_1 | g9919 | g9919.t1 | exon | g9919.t1.exon1 | 6046594 | 6046783 |
| chr_1 | g9919 | g9919.t1 | cds | g9919.t1.CDS1 | 6046594 | 6046783 |
| chr_1 | g9919 | g9919.t1 | exon | g9919.t1.exon2 | 6046841 | 6047208 |
| chr_1 | g9919 | g9919.t1 | cds | g9919.t1.CDS2 | 6046841 | 6047208 |
| chr_1 | g9919 | g9919.t1 | exon | g9919.t1.exon3 | 6047267 | 6047683 |
| chr_1 | g9919 | g9919.t1 | cds | g9919.t1.CDS3 | 6047267 | 6047683 |
| chr_1 | g9919 | g9919.t1 | TTS | g9919.t1 | 6047801 | 6047801 |
Sequences
>g9919.t1 Gene=g9919 Length=975
ATGCATAGAAATATTCAACAAAAAGTTTATCAGCCTGAAGATTTAGCTTCACTGGTTGCA
CATTTGCCCGAGAATCTTCAAGATCCTGTAACACAGATACATTATAATATAATGAATCAT
GAAGCTTATAACAATCAAAATTATGCCTGGTCTAAAGAGGATTTTGAGCTTGGAACAGCA
TTAGGAAGAGGAAAATTCGGAAGGGTTTATATGGCACGCGAAAAAAGGTCAAAATATCTG
GTTGCAATGAAAATTTTATTCAAAAGTGAATTAGTCAAAGGAAGAGTTGAGAAACAAGTA
TTACGTGAATTAGAAATTCAATCGAGATTGAAGCATCCCAATATTCTTCGCATGTTTACA
TGGTTCTATGATGATCGTAAAATTTACATTGCTTTAGAATTAGCTTCACAAGGAGAACTC
TATAAACATTTGAAAAATGCTCCAAACGGAAGATTTGATGAACATAGAGCAGCCAGATAC
ACTTATCAAGTTGCTGATGCTCTTAATTATTGCCATTTGAACAATGTCATTCATCGTGAT
TTAAAGCCTGAAAATTTGTTATTGACAGAAGATGACAATGTAAAGCTCGCTGATTTTGGA
TGGTCAGCTCATACTTTATCGAATAAACGAAAAACAATGTGTGGTACTCTCGATTATCTT
CCACCAGAAATGGTAGAAGGAAGACAGTATGATGATTCAGTCGATCAGTGGTGTTTAGGC
ATTCTTTGCTATGAATTTCTCGTTGGATCACCACCTTTTGAATCAGAGGATGCTGAGAGG
ACTTATGAAAAAATCAAACGCATTGATGTAGTCTATCCAAAATATGTGTCTCAAGGTGCA
TGTGATTTGATTTCTAAATTACTTCGTCGACATGGACTGCGAATTTCTCTTCGTGAAGTA
ATGACTCATTCTTGGATCAAGGAAAATACAAAAAAACCTTTACGTGAAACATTTCTCTTA
AATCATAAGAAATAA
>g9919.t1 Gene=g9919 Length=324
MHRNIQQKVYQPEDLASLVAHLPENLQDPVTQIHYNIMNHEAYNNQNYAWSKEDFELGTA
LGRGKFGRVYMAREKRSKYLVAMKILFKSELVKGRVEKQVLRELEIQSRLKHPNILRMFT
WFYDDRKIYIALELASQGELYKHLKNAPNGRFDEHRAARYTYQVADALNYCHLNNVIHRD
LKPENLLLTEDDNVKLADFGWSAHTLSNKRKTMCGTLDYLPPEMVEGRQYDDSVDQWCLG
ILCYEFLVGSPPFESEDAERTYEKIKRIDVVYPKYVSQGACDLISKLLRRHGLRISLREV
MTHSWIKENTKKPLRETFLLNHKK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g9919.t1 | CDD | cd14007 | STKc_Aurora | 54 | 307 | 1.45198E-151 |
| 5 | g9919.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 42 | 137 | 3.1E-28 |
| 6 | g9919.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 138 | 310 | 8.3E-58 |
| 2 | g9919.t1 | PANTHER | PTHR24350 | SERINE/THREONINE-PROTEIN KINASE IAL-RELATED | 20 | 312 | 4.9E-157 |
| 3 | g9919.t1 | PANTHER | PTHR24350:SF24 | AURORA KINASE B | 20 | 312 | 4.9E-157 |
| 1 | g9919.t1 | Pfam | PF00069 | Protein kinase domain | 56 | 306 | 1.6E-67 |
| 9 | g9919.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 61 | 84 | - |
| 8 | g9919.t1 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 176 | 188 | - |
| 11 | g9919.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 55 | 306 | 47.227 |
| 10 | g9919.t1 | SMART | SM00220 | serkin_6 | 55 | 306 | 6.4E-91 |
| 4 | g9919.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 37 | 315 | 6.12E-83 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0032467 | positive regulation of cytokinesis | BP |
| GO:0005524 | ATP binding | MF |
| GO:0006468 | protein phosphorylation | BP |
| GO:0007094 | mitotic spindle assembly checkpoint signaling | BP |
| GO:0032133 | chromosome passenger complex | CC |
| GO:0004674 | protein serine/threonine kinase activity | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0043988 | histone H3-S28 phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K11479 (aurora kinase B)
Pathway
This gene does not belong to any pathways.
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
