General information for g9919.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aurora kinase B.
Parent gene
- The parent gene g9919 is located on chr_1: 6047683..6048752 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g9919 | g9919.t2 | isoform | g9919.t2 | 6035062 | 6047683 |
| chr_1 | g9919 | g9919.t2 | exon | g9919.t2.exon1 | 6035062 | 6035069 |
| chr_1 | g9919 | g9919.t2 | exon | g9919.t2.exon2 | 6043906 | 6044125 |
| chr_1 | g9919 | g9919.t2 | exon | g9919.t2.exon3 | 6046602 | 6046783 |
| chr_1 | g9919 | g9919.t2 | cds | g9919.t2.CDS1 | 6046705 | 6046783 |
| chr_1 | g9919 | g9919.t2 | exon | g9919.t2.exon4 | 6046841 | 6047208 |
| chr_1 | g9919 | g9919.t2 | cds | g9919.t2.CDS2 | 6046841 | 6047208 |
| chr_1 | g9919 | g9919.t2 | exon | g9919.t2.exon5 | 6047267 | 6047683 |
| chr_1 | g9919 | g9919.t2 | cds | g9919.t2.CDS3 | 6047267 | 6047683 |
| chr_1 | g9919 | g9919.t2 | TTS | g9919.t2 | 6047801 | 6047801 |
| chr_1 | g9919 | g9919.t2 | TSS | g9919.t2 | NA | NA |
Sequences
>g9919.t2 Gene=g9919 Length=1195
TTTTCTTTTTTCATTTTTGTTAAAAATAAAATTTTATTTTTCAATTTTAAGTCATTTTAC
AATAGTCTTAAAAAAAGTATTTTTAGTCTGTTCCAAGAAGCTGTCTTATTTCATTGTCAA
ATTCTGTTGCAGTTGGTTCTAATTCCATATCAACTTCAGTTGCATCTACATCAATTGTTT
TACCACTCGATGGATATTTTGGTGCTTTTCTAAAATCACTCTCAGATGAAATATTCAACA
AAAAGTTTATCAGCCTGAAGATTTAGCTTCACTGGTTGCACATTTGCCCGAGAATCTTCA
AGATCCTGTAACACAGATACATTATAATATAATGAATCATGAAGCTTATAACAATCAAAA
TTATGCCTGGTCTAAAGAGGATTTTGAGCTTGGAACAGCATTAGGAAGAGGAAAATTCGG
AAGGGTTTATATGGCACGCGAAAAAAGGTCAAAATATCTGGTTGCAATGAAAATTTTATT
CAAAAGTGAATTAGTCAAAGGAAGAGTTGAGAAACAAGTATTACGTGAATTAGAAATTCA
ATCGAGATTGAAGCATCCCAATATTCTTCGCATGTTTACATGGTTCTATGATGATCGTAA
AATTTACATTGCTTTAGAATTAGCTTCACAAGGAGAACTCTATAAACATTTGAAAAATGC
TCCAAACGGAAGATTTGATGAACATAGAGCAGCCAGATACACTTATCAAGTTGCTGATGC
TCTTAATTATTGCCATTTGAACAATGTCATTCATCGTGATTTAAAGCCTGAAAATTTGTT
ATTGACAGAAGATGACAATGTAAAGCTCGCTGATTTTGGATGGTCAGCTCATACTTTATC
GAATAAACGAAAAACAATGTGTGGTACTCTCGATTATCTTCCACCAGAAATGGTAGAAGG
AAGACAGTATGATGATTCAGTCGATCAGTGGTGTTTAGGCATTCTTTGCTATGAATTTCT
CGTTGGATCACCACCTTTTGAATCAGAGGATGCTGAGAGGACTTATGAAAAAATCAAACG
CATTGATGTAGTCTATCCAAAATATGTGTCTCAAGGTGCATGTGATTTGATTTCTAAATT
ACTTCGTCGACATGGACTGCGAATTTCTCTTCGTGAAGTAATGACTCATTCTTGGATCAA
GGAAAATACAAAAAAACCTTTACGTGAAACATTTCTCTTAAATCATAAGAAATAA
>g9919.t2 Gene=g9919 Length=287
MNHEAYNNQNYAWSKEDFELGTALGRGKFGRVYMAREKRSKYLVAMKILFKSELVKGRVE
KQVLRELEIQSRLKHPNILRMFTWFYDDRKIYIALELASQGELYKHLKNAPNGRFDEHRA
ARYTYQVADALNYCHLNNVIHRDLKPENLLLTEDDNVKLADFGWSAHTLSNKRKTMCGTL
DYLPPEMVEGRQYDDSVDQWCLGILCYEFLVGSPPFESEDAERTYEKIKRIDVVYPKYVS
QGACDLISKLLRRHGLRISLREVMTHSWIKENTKKPLRETFLLNHKK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g9919.t2 | CDD | cd14007 | STKc_Aurora | 17 | 270 | 1.52145E-152 |
| 5 | g9919.t2 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 5 | 100 | 2.5E-28 |
| 6 | g9919.t2 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 101 | 273 | 5.9E-58 |
| 2 | g9919.t2 | PANTHER | PTHR24350 | SERINE/THREONINE-PROTEIN KINASE IAL-RELATED | 2 | 275 | 6.6E-156 |
| 3 | g9919.t2 | PANTHER | PTHR24350:SF24 | AURORA KINASE B | 2 | 275 | 6.6E-156 |
| 7 | g9919.t2 | PIRSF | PIRSF000654 | ILK | 2 | 266 | 1.4E-31 |
| 1 | g9919.t2 | Pfam | PF00069 | Protein kinase domain | 19 | 269 | 1.1E-67 |
| 10 | g9919.t2 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 24 | 47 | - |
| 9 | g9919.t2 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 139 | 151 | - |
| 12 | g9919.t2 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 18 | 269 | 47.227 |
| 11 | g9919.t2 | SMART | SM00220 | serkin_6 | 18 | 269 | 6.4E-91 |
| 4 | g9919.t2 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 10 | 278 | 9.19E-83 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0032467 | positive regulation of cytokinesis | BP |
| GO:0005524 | ATP binding | MF |
| GO:0006468 | protein phosphorylation | BP |
| GO:0007094 | mitotic spindle assembly checkpoint signaling | BP |
| GO:0032133 | chromosome passenger complex | CC |
| GO:0004674 | protein serine/threonine kinase activity | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0043988 | histone H3-S28 phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K11479 (aurora kinase B)
Pathway
This gene does not belong to any pathways.
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
