General information for g9919.t3
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aurora kinase B.
Parent gene
- The parent gene g9919 is located on chr_1: 6047683..6048752 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g9919 | g9919.t3 | TSS | g9919.t3 | 6046533 | 6046533 |
| chr_1 | g9919 | g9919.t3 | isoform | g9919.t3 | 6046594 | 6047683 |
| chr_1 | g9919 | g9919.t3 | exon | g9919.t3.exon1 | 6046594 | 6047208 |
| chr_1 | g9919 | g9919.t3 | cds | g9919.t3.CDS1 | 6046897 | 6047208 |
| chr_1 | g9919 | g9919.t3 | exon | g9919.t3.exon2 | 6047267 | 6047683 |
| chr_1 | g9919 | g9919.t3 | cds | g9919.t3.CDS2 | 6047267 | 6047683 |
| chr_1 | g9919 | g9919.t3 | TTS | g9919.t3 | 6047801 | 6047801 |
Sequences
>g9919.t3 Gene=g9919 Length=1032
ATGCATAGAAATATTCAACAAAAAGTTTATCAGCCTGAAGATTTAGCTTCACTGGTTGCA
CATTTGCCCGAGAATCTTCAAGATCCTGTAACACAGATACATTATAATATAATGAATCAT
GAAGCTTATAACAATCAAAATTATGCCTGGTCTAAAGAGGATTTTGAGCTTGGAACAGCA
TTAGGAAGAGGTAAATTATCGTAATAATAAGAAAATAATTGAAATTTATTGTTATCTTTT
TATAAAGGAAAATTCGGAAGGGTTTATATGGCACGCGAAAAAAGGTCAAAATATCTGGTT
GCAATGAAAATTTTATTCAAAAGTGAATTAGTCAAAGGAAGAGTTGAGAAACAAGTATTA
CGTGAATTAGAAATTCAATCGAGATTGAAGCATCCCAATATTCTTCGCATGTTTACATGG
TTCTATGATGATCGTAAAATTTACATTGCTTTAGAATTAGCTTCACAAGGAGAACTCTAT
AAACATTTGAAAAATGCTCCAAACGGAAGATTTGATGAACATAGAGCAGCCAGATACACT
TATCAAGTTGCTGATGCTCTTAATTATTGCCATTTGAACAATGTCATTCATCGTGATTTA
AAGCCTGAAAATTTGTTATTGACAGAAGATGACAATGTAAAGCTCGCTGATTTTGGATGG
TCAGCTCATACTTTATCGAATAAACGAAAAACAATGTGTGGTACTCTCGATTATCTTCCA
CCAGAAATGGTAGAAGGAAGACAGTATGATGATTCAGTCGATCAGTGGTGTTTAGGCATT
CTTTGCTATGAATTTCTCGTTGGATCACCACCTTTTGAATCAGAGGATGCTGAGAGGACT
TATGAAAAAATCAAACGCATTGATGTAGTCTATCCAAAATATGTGTCTCAAGGTGCATGT
GATTTGATTTCTAAATTACTTCGTCGACATGGACTGCGAATTTCTCTTCGTGAAGTAATG
ACTCATTCTTGGATCAAGGAAAATACAAAAAAACCTTTACGTGAAACATTTCTCTTAAAT
CATAAGAAATAA
>g9919.t3 Gene=g9919 Length=242
MKILFKSELVKGRVEKQVLRELEIQSRLKHPNILRMFTWFYDDRKIYIALELASQGELYK
HLKNAPNGRFDEHRAARYTYQVADALNYCHLNNVIHRDLKPENLLLTEDDNVKLADFGWS
AHTLSNKRKTMCGTLDYLPPEMVEGRQYDDSVDQWCLGILCYEFLVGSPPFESEDAERTY
EKIKRIDVVYPKYVSQGACDLISKLLRRHGLRISLREVMTHSWIKENTKKPLRETFLLNH
KK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g9919.t3 | CDD | cd14007 | STKc_Aurora | 1 | 225 | 7.15548E-132 |
| 5 | g9919.t3 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 1 | 241 | 5.4E-75 |
| 2 | g9919.t3 | PANTHER | PTHR24350 | SERINE/THREONINE-PROTEIN KINASE IAL-RELATED | 1 | 230 | 6.5E-131 |
| 3 | g9919.t3 | PANTHER | PTHR24350:SF24 | AURORA KINASE B | 1 | 230 | 6.5E-131 |
| 6 | g9919.t3 | PIRSF | PIRSF000654 | ILK | 1 | 223 | 1.1E-28 |
| 1 | g9919.t3 | Pfam | PF00069 | Protein kinase domain | 2 | 224 | 4.7E-58 |
| 8 | g9919.t3 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 94 | 106 | - |
| 10 | g9919.t3 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 1 | 224 | 40.979 |
| 9 | g9919.t3 | SMART | SM00220 | serkin_6 | 1 | 224 | 3.8E-64 |
| 4 | g9919.t3 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 1 | 232 | 1.6E-70 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0032467 | positive regulation of cytokinesis | BP |
| GO:0005524 | ATP binding | MF |
| GO:0006468 | protein phosphorylation | BP |
| GO:0007094 | mitotic spindle assembly checkpoint signaling | BP |
| GO:0032133 | chromosome passenger complex | CC |
| GO:0004674 | protein serine/threonine kinase activity | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0043988 | histone H3-S28 phosphorylation | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
