General information for g11018.t3
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as RAC serine/threonine-protein kinase.
Parent gene
- The parent gene g11018 is located on chr_1: 13423510..13425801 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11018 | g11018.t3 | isoform | g11018.t3 | 13422172 | 13423668 |
| chr_1 | g11018 | g11018.t3 | exon | g11018.t3.exon1 | 13422172 | 13422751 |
| chr_1 | g11018 | g11018.t3 | cds | g11018.t3.CDS1 | 13422262 | 13422751 |
| chr_1 | g11018 | g11018.t3 | exon | g11018.t3.exon2 | 13422811 | 13422975 |
| chr_1 | g11018 | g11018.t3 | cds | g11018.t3.CDS2 | 13422811 | 13422975 |
| chr_1 | g11018 | g11018.t3 | exon | g11018.t3.exon3 | 13423039 | 13423190 |
| chr_1 | g11018 | g11018.t3 | cds | g11018.t3.CDS3 | 13423039 | 13423190 |
| chr_1 | g11018 | g11018.t3 | exon | g11018.t3.exon4 | 13423248 | 13423445 |
| chr_1 | g11018 | g11018.t3 | cds | g11018.t3.CDS4 | 13423248 | 13423445 |
| chr_1 | g11018 | g11018.t3 | exon | g11018.t3.exon5 | 13423509 | 13423668 |
| chr_1 | g11018 | g11018.t3 | cds | g11018.t3.CDS5 | 13423509 | 13423592 |
| chr_1 | g11018 | g11018.t3 | TSS | g11018.t3 | NA | NA |
| chr_1 | g11018 | g11018.t3 | TTS | g11018.t3 | NA | NA |
Sequences
>g11018.t3 Gene=g11018 Length=1255
TGTTGCAAACTGTTTGAGCGAAATTGATCAACAAGAAGAGCCAGTAGCAGAATTGAATGA
TAATGATGATGTAGAAATGGCATCAATTGCGGAAGAAGAAGAATTGGATGAAAAACTCTC
TCATCAAGGAACATCGACAGGAAGTGGAAAGAAGAAAATTACATTAGAGAATTTTGAATT
TTTAAAAGTGCTTGGACGAGGGTCTTATGGCAAAGTAATTTTATGTCGGGAAAAATCTAC
AGCCAAGTTATATGCGATAAAAATCCTTAAAAAGGAAGTCATCATACAAAAGAGTGAAGT
CGAACACACGATGGCTGAAAATCGAGTTTTACGCAAGACAAATCATCCATTTTTAATTTC
ATTGCGTTATTCATTTCGCACTAATGAGCGACTATGTTTTGTCATGCAGTATGTCAACGG
CGGTGAATTATATTTTCATCTGAGAAATGAAAAAATATTTTCAGAAGATCGTACTCGATT
TTATGGAGCAGAAATCATTTCAGCACTTGGATATTTGCATTCGCACAACATTGTTTATCG
TGATGTAAAATTAGAGAATCTTTTACTTGATAAAGATGGTCATATAAAAATTGCAGATTT
TGGTTTATGTAAGGAAGATATTACATATGATAGAACAACGAATACATTTTGTGGAACACC
TGAATATTTGGCACCAGAAATGTTAGAAGACAACGATTATGGATTAGCAGTCGATTGGTG
GGGCACGGGTGTCGTCATGTACGAAATGATGTGTGGTCAATTACCGTTTGATAATCGTGA
CCATGACATTTTATTCAAGCAAATTATGATGGATGATGTAAAGTTTCGACGCCCTGTTTC
TAGTGAAGCAAAATCACTTTTAACTGGATTACTTGAAAAAAGTCCCCAAAAGCGCCTCGG
TGGTGGACCAGATGATGTTCGAGAAATAATGGTGCATCCTTTCTTTGCTAGCATCAATTG
GTATGATTTAGTGAATAAGAAAATTATTCCACCGTTCAAGCCGCAAGTTACCTCAGATAC
TGATACACGCTATTTCGATTCTGAATTTACGGGTGAGAGTGTCGAATTGACACCGCCTGA
TCCAGCTGTTCAATTACAATCAATTCAGGAAGAACCTCATTTTTCTCAAGTAAGTATGGT
CATGATTATAAAAGTGACTATATAATTCAATATGAATCTTTCAAAATTGCAGTTCAGTTA
TCAAGCAATTGCTTCATTTATGAGCAACAATTCTGCATTAGTTTCATTACCATAG
>g11018.t3 Gene=g11018 Length=362
MASIAEEEELDEKLSHQGTSTGSGKKKITLENFEFLKVLGRGSYGKVILCREKSTAKLYA
IKILKKEVIIQKSEVEHTMAENRVLRKTNHPFLISLRYSFRTNERLCFVMQYVNGGELYF
HLRNEKIFSEDRTRFYGAEIISALGYLHSHNIVYRDVKLENLLLDKDGHIKIADFGLCKE
DITYDRTTNTFCGTPEYLAPEMLEDNDYGLAVDWWGTGVVMYEMMCGQLPFDNRDHDILF
KQIMMDDVKFRRPVSSEAKSLLTGLLEKSPQKRLGGGPDDVREIMVHPFFASINWYDLVN
KKIIPPFKPQVTSDTDTRYFDSEFTGESVELTPPDPAVQLQSIQEEPHFSQVSMVMIIKV
TI
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g11018.t3 | CDD | cd05571 | STKc_PKB | 37 | 353 | 0.0 |
| 6 | g11018.t3 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 31 | 327 | 8.6E-133 |
| 7 | g11018.t3 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 117 | 311 | 8.6E-133 |
| 13 | g11018.t3 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 21 | - |
| 14 | g11018.t3 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 15 | - |
| 3 | g11018.t3 | PANTHER | PTHR24351:SF209 | NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE | 7 | 345 | 9.6E-192 |
| 4 | g11018.t3 | PANTHER | PTHR24351 | RIBOSOMAL PROTEIN S6 KINASE | 7 | 345 | 9.6E-192 |
| 2 | g11018.t3 | Pfam | PF00069 | Protein kinase domain | 33 | 290 | 1.6E-74 |
| 1 | g11018.t3 | Pfam | PF00433 | Protein kinase C terminal domain | 311 | 337 | 1.6E-7 |
| 10 | g11018.t3 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 39 | 62 | - |
| 9 | g11018.t3 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 152 | 164 | - |
| 16 | g11018.t3 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 33 | 290 | 48.781 |
| 15 | g11018.t3 | ProSiteProfiles | PS51285 | AGC-kinase C-terminal domain profile. | 291 | 362 | 13.583 |
| 12 | g11018.t3 | SMART | SM00220 | serkin_6 | 33 | 290 | 1.8E-105 |
| 11 | g11018.t3 | SMART | SM00133 | pkinase_C_6 | 291 | 353 | 1.2E-16 |
| 5 | g11018.t3 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 28 | 345 | 6.61E-97 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005524 | ATP binding | MF |
| GO:0004674 | protein serine/threonine kinase activity | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K13303 (serum/glucocorticoid-regulated kinase 2)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
