General information for g2453.t141
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Serine protease inhibitor 42Dd.
Parent gene
- The parent gene g2453 is located on chr_3: 18040351..18047135 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2453 | g2453.t141 | TTS | g2453.t141 | 18037897 | 18037897 |
| chr_3 | g2453 | g2453.t141 | isoform | g2453.t141 | 18038034 | 18040714 |
| chr_3 | g2453 | g2453.t141 | exon | g2453.t141.exon1 | 18038034 | 18038089 |
| chr_3 | g2453 | g2453.t141 | cds | g2453.t141.CDS1 | 18038034 | 18038089 |
| chr_3 | g2453 | g2453.t141 | exon | g2453.t141.exon2 | 18038878 | 18039019 |
| chr_3 | g2453 | g2453.t141 | cds | g2453.t141.CDS2 | 18038878 | 18039019 |
| chr_3 | g2453 | g2453.t141 | exon | g2453.t141.exon3 | 18039101 | 18039684 |
| chr_3 | g2453 | g2453.t141 | cds | g2453.t141.CDS3 | 18039101 | 18039684 |
| chr_3 | g2453 | g2453.t141 | exon | g2453.t141.exon4 | 18039768 | 18039975 |
| chr_3 | g2453 | g2453.t141 | cds | g2453.t141.CDS4 | 18039768 | 18039975 |
| chr_3 | g2453 | g2453.t141 | exon | g2453.t141.exon5 | 18040042 | 18040157 |
| chr_3 | g2453 | g2453.t141 | cds | g2453.t141.CDS5 | 18040042 | 18040157 |
| chr_3 | g2453 | g2453.t141 | exon | g2453.t141.exon6 | 18040582 | 18040641 |
| chr_3 | g2453 | g2453.t141 | cds | g2453.t141.CDS6 | 18040582 | 18040630 |
| chr_3 | g2453 | g2453.t141 | exon | g2453.t141.exon7 | 18040698 | 18040714 |
| chr_3 | g2453 | g2453.t141 | TSS | g2453.t141 | 18040724 | 18040724 |
Sequences
>g2453.t141 Gene=g2453 Length=1183
TAAATTTATAAACACAGTAAACATTTTCATGCATAAAGTTCTTTCAATTCTACAATTCAG
TAATCAATTTGAAACAGTAATTCTCTCAGTTTGTGCTCTGACTATCGTGCTAAACGCATC
AATGGCGTCACCCTCTGAAATCGAACAAAAGTTTTCAAAATCAGCCAGCAACTTTGCTGC
TAAATTGTACCAAAACTCAATTCAAGGAAAAACTGGCAATGTAATTATTTCACCTGTCTC
AGTTCAAACAGCCGTCACTTTGGCTATGTTTGGTGCTGCTGGTGAGACCAAGCAAGAAAT
GTTAAAAGGTCTCGAATATCAGGGTTTCACTGATCAAATAATTGCTGATAACTATCAACG
ATTTGGCGAGAGCGTCGCAAAGACTAATGGATTGAAAATCGCTAATAAGATTTATGTGAT
GAAAGGCTATTCAGTCAAGCCAACATTCCAGCAAGTCGCAACAAAGAGTTTCAATTCAGA
AGCTGAAGATGTAAATTTCGCACAAAGTAAAGACTCAGCTGGCAAAATCAATACATGGGT
TGAAAATCAAACAAATAATAAAATTAAAAATCTTATCTCACCTGATTCATTGGATGCTGA
CACACGTATGGTTCTTGTAAATGCCATTTACTTCAAAGGATTCTGGACCTATCAATTTGA
TCCAAAAGCAACATTCAAAGCACCATTCTTTCTCAATGATAATGATAAAGTTGATGTTGA
TTTCATGAAAATTAAGAAACATTTCAAATATGGACGATTTGATGATCTTGATGCAACTGC
ATTGGAATTGCCTTACAAAGATTCTGATATTACAATGTTGATAATTTTACCAAATAAACG
CACTGGATTGGCTGAATTGGAGAGCAAATTGGACACAATTGACTTCAATGAGCTCACAAC
AAAGATGTATTCGGAAGAAGTTAATGTTGAATTGCCAAAGTTTAAAATTGAATTTGACAT
TGAATTGACCGAGCCATTAAAGAAGATGGGAATGGAGAAAATGTTCTCAGATGCTGCTCA
ATTTGATGAATTGCTTACATCGACTGAACCTCTCAAGGTTTCACAAGTTGTTCATAAAGC
CTTCATTGAAGTCAATGAAGAAGGTGCTGAAGCAGCTGCTGCTACAGCTATCACTATAAC
TCTATGCAGTTTTGTTGAATTTCCAACAAAATTTCAAGCAAAT
>g2453.t141 Gene=g2453 Length=385
MHKVLSILQFSNQFETVILSVCALTIVLNASMASPSEIEQKFSKSASNFAAKLYQNSIQG
KTGNVIISPVSVQTAVTLAMFGAAGETKQEMLKGLEYQGFTDQIIADNYQRFGESVAKTN
GLKIANKIYVMKGYSVKPTFQQVATKSFNSEAEDVNFAQSKDSAGKINTWVENQTNNKIK
NLISPDSLDADTRMVLVNAIYFKGFWTYQFDPKATFKAPFFLNDNDKVDVDFMKIKKHFK
YGRFDDLDATALELPYKDSDITMLIILPNKRTGLAELESKLDTIDFNELTTKMYSEEVNV
ELPKFKIEFDIELTEPLKKMGMEKMFSDAAQFDELLTSTEPLKVSQVVHKAFIEVNEEGA
EAAAATAITITLCSFVEFPTKFQAN
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g2453.t141 | CDD | cd19601 | serpin42Da-like | 45 | 356 | 1.22102E-147 |
| 7 | g2453.t141 | Gene3D | G3DSA:3.30.497.10 | Antithrombin | 61 | 352 | 8.3E-114 |
| 6 | g2453.t141 | Gene3D | G3DSA:2.30.39.10 | - | 202 | 385 | 8.3E-114 |
| 2 | g2453.t141 | PANTHER | PTHR11461 | SERINE PROTEASE INHIBITOR, SERPIN | 42 | 383 | 1.4E-83 |
| 3 | g2453.t141 | PANTHER | PTHR11461:SF180 | LEUKOCYTE ELASTASE INHIBITOR | 42 | 383 | 1.4E-83 |
| 1 | g2453.t141 | Pfam | PF00079 | Serpin (serine protease inhibitor) | 45 | 385 | 1.9E-105 |
| 9 | g2453.t141 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 33 | - |
| 10 | g2453.t141 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 16 | - |
| 11 | g2453.t141 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 17 | 28 | - |
| 12 | g2453.t141 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 29 | 33 | - |
| 8 | g2453.t141 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 34 | 385 | - |
| 5 | g2453.t141 | SMART | SM00093 | serpin2 | 51 | 379 | 1.8E-105 |
| 4 | g2453.t141 | SUPERFAMILY | SSF56574 | Serpins | 31 | 385 | 2.62E-112 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005615 | extracellular space | CC |
| GO:0004867 | serine-type endopeptidase inhibitor activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
