General information for g2453.t171
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative Alaserpin.
Parent gene
- The parent gene g2453 is located on chr_3: 18040351..18047135 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2453 | g2453.t171 | TTS | g2453.t171 | 18038507 | 18038507 |
| chr_3 | g2453 | g2453.t171 | isoform | g2453.t171 | 18038937 | 18042146 |
| chr_3 | g2453 | g2453.t171 | exon | g2453.t171.exon1 | 18038937 | 18039019 |
| chr_3 | g2453 | g2453.t171 | cds | g2453.t171.CDS1 | 18038939 | 18039019 |
| chr_3 | g2453 | g2453.t171 | exon | g2453.t171.exon2 | 18039101 | 18039684 |
| chr_3 | g2453 | g2453.t171 | cds | g2453.t171.CDS2 | 18039101 | 18039684 |
| chr_3 | g2453 | g2453.t171 | exon | g2453.t171.exon3 | 18039768 | 18039975 |
| chr_3 | g2453 | g2453.t171 | cds | g2453.t171.CDS3 | 18039768 | 18039975 |
| chr_3 | g2453 | g2453.t171 | exon | g2453.t171.exon4 | 18040042 | 18040157 |
| chr_3 | g2453 | g2453.t171 | cds | g2453.t171.CDS4 | 18040042 | 18040157 |
| chr_3 | g2453 | g2453.t171 | exon | g2453.t171.exon5 | 18041800 | 18042146 |
| chr_3 | g2453 | g2453.t171 | cds | g2453.t171.CDS5 | 18041800 | 18041830 |
| chr_3 | g2453 | g2453.t171 | TSS | g2453.t171 | 18042146 | 18042146 |
Sequences
>g2453.t171 Gene=g2453 Length=1338
GTTTGAAATCGTTCATTGAGAAAAGAACACGTGAAAAAAAAATAATTTAGTCACAAATCA
GTAAAATTGTTGTGATAAATTTTCCATTAATTTCCTAGTTTTTTTAAGTTAATATTTACA
AAGGCCATTATGTCAAATAAAAAATTTAATGTCACAAACTAATTGAATTTTAGCTACTGA
TGGTTTTTATGATTATTAGTGTGAAAAATACCAAATACGAGCCAAATAATATTATTGAAC
TTGAGTGAGCTTATATAAACATATATTGTCGTCATTAACATTTACTGTTTAGAAAAAAAT
TACTGAAATCAGAAATATGATTTTATCAAAACTTGTTAATAAAACATTAATTCTCTCAGT
TTGTGCTCTGACTATCGTGCTAAACGCATCAATGGCGTCACCCTCTGAAATCGAACAAAA
GTTTTCAAAATCAGCCAGCAACTTTGCTGCTAAATTGTACCAAAACTCAATTCAAGGAAA
AACTGGCAATGTAATTATTTCACCTGTCTCAGTTCAAACAGCCGTCACTTTGGCTATGTT
TGGTGCTGCTGGTGAGACCAAGCAAGAAATGTTAAAAGGTCTCGAATATCAGGGTTTCAC
TGATCAAATAATTGCTGATAACTATCAACGATTTGGCGAGAGCGTCGCAAAGACTAATGG
ATTGAAAATCGCTAATAAGATTTATGTGATGAAAGGCTATTCAGTCAAGCCAACATTCCA
GCAAGTCGCAACAAAGAGTTTCAATTCAGAAGCTGAAGATGTAAATTTCGCACAAAGTAA
AGACTCAGCTGGCAAAATCAATACATGGGTTGAAAATCAAACAAATAATAAAATTAAAAA
TCTTATCTCACCTGATTCATTGGATGCTGACACACGTATGGTTCTTGTAAATGCCATTTA
CTTCAAAGGATTCTGGACCTATCAATTTGATCCAAAAGCAACATTCAAAGCACCATTCTT
TCTCAATGATAATGATAAAGTTGATGTTGATTTCATGAAAATTAAGAAACATTTCAAATA
TGGACGATTTGATGATCTTGATGCAACTGCATTGGAATTGCCTTACAAAGATTCTGATAT
TACAATGTTGATAATTTTACCAAATAAACGCACTGGATTGGCTGAATTGGAGAGCAAATT
GGACACAATTGACTTCAATGAGCTCACAACAAAGATGTATTCGGAAGAAGTTAATGTTGA
ATTGCCAAAGTTTAAAATTGAATTTGACATTGAATTGACCGAGCCATTAAAGAAGATGGG
AATGGAGAAAATGTTCTCAGATGCTGCTCAATTTGATGAATTGCTTACATCGACTGAACC
TCTCAAGGTTTCACAAGT
>g2453.t171 Gene=g2453 Length=340
MILSKLVNKTLILSVCALTIVLNASMASPSEIEQKFSKSASNFAAKLYQNSIQGKTGNVI
ISPVSVQTAVTLAMFGAAGETKQEMLKGLEYQGFTDQIIADNYQRFGESVAKTNGLKIAN
KIYVMKGYSVKPTFQQVATKSFNSEAEDVNFAQSKDSAGKINTWVENQTNNKIKNLISPD
SLDADTRMVLVNAIYFKGFWTYQFDPKATFKAPFFLNDNDKVDVDFMKIKKHFKYGRFDD
LDATALELPYKDSDITMLIILPNKRTGLAELESKLDTIDFNELTTKMYSEEVNVELPKFK
IEFDIELTEPLKKMGMEKMFSDAAQFDELLTSTEPLKVSQ
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 14 | g2453.t171 | CDD | cd19601 | serpin42Da-like | 39 | 340 | 1.86486E-138 |
| 7 | g2453.t171 | Gene3D | G3DSA:2.30.39.10 | - | 39 | 307 | 2.2E-99 |
| 8 | g2453.t171 | Gene3D | G3DSA:3.30.497.10 | Antithrombin | 63 | 340 | 2.2E-99 |
| 2 | g2453.t171 | PANTHER | PTHR11461 | SERINE PROTEASE INHIBITOR, SERPIN | 36 | 339 | 2.8E-68 |
| 3 | g2453.t171 | PANTHER | PTHR11461:SF180 | LEUKOCYTE ELASTASE INHIBITOR | 36 | 339 | 2.8E-68 |
| 1 | g2453.t171 | Pfam | PF00079 | Serpin (serine protease inhibitor) | 39 | 340 | 1.7E-90 |
| 10 | g2453.t171 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 27 | - |
| 11 | g2453.t171 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 10 | - |
| 12 | g2453.t171 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 11 | 22 | - |
| 13 | g2453.t171 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 23 | 27 | - |
| 9 | g2453.t171 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 28 | 340 | - |
| 16 | g2453.t171 | SMART | SM00093 | serpin2 | 45 | 340 | 2.6E-71 |
| 4 | g2453.t171 | SUPERFAMILY | SSF56574 | Serpins | 26 | 340 | 1.7E-96 |
| 6 | g2453.t171 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 27 | - |
| 15 | g2453.t171 | SignalP_GRAM_NEGATIVE | SignalP-noTM | SignalP-noTM | 1 | 26 | - |
| 5 | g2453.t171 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM | 1 | 27 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005615 | extracellular space | CC |
| GO:0004867 | serine-type endopeptidase inhibitor activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed