General information for g2453.t174
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative Leukocyte elastase inhibitor.
Parent gene
- The parent gene g2453 is located on chr_3: 18040351..18047135 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2453 | g2453.t174 | TTS | g2453.t174 | 18038507 | 18038507 |
| chr_3 | g2453 | g2453.t174 | isoform | g2453.t174 | 18038981 | 18040030 |
| chr_3 | g2453 | g2453.t174 | exon | g2453.t174.exon1 | 18038981 | 18039501 |
| chr_3 | g2453 | g2453.t174 | cds | g2453.t174.CDS1 | 18039095 | 18039501 |
| chr_3 | g2453 | g2453.t174 | exon | g2453.t174.exon2 | 18039565 | 18039684 |
| chr_3 | g2453 | g2453.t174 | cds | g2453.t174.CDS2 | 18039565 | 18039667 |
| chr_3 | g2453 | g2453.t174 | exon | g2453.t174.exon3 | 18039746 | 18040030 |
| chr_3 | g2453 | g2453.t174 | TSS | g2453.t174 | 18040147 | 18040147 |
Sequences
>g2453.t174 Gene=g2453 Length=926
TTTTTTAAACTTTTATTTTAACTTTTTCAACAAGTGTTTTTGTCACTTTATTTAGAACTC
AATTCAAGGAAAAACTGGCAATGTAATTATTTCACCTGTCTCAGTTCAAACAGCCGTCAC
TTTGGCTATGTTTGGTGCTGCTGGTGAGACCAAGCAAGAAATGTTAAAAGGTCTCGAATA
TCAGGGTTTCACTGATCAAATAATTGCTGATAACTATCAACGATTTGGCGAGAGCGTCGC
AAAGACTAATGGATTGAAAATCGGTAAGAAAACCTTCAGAAATAACTAATAAGATTTATG
TGATGAAAGGCTATTCAGTCAAGCCAACATTCCAGCAAGTCGCAACAAAGAGTTTCAATT
CAGAAGCTGAAGATGTAAATTTCGCACAAAGTAAAGACTCAGCTGATTCATTGGATGCTG
ACACACGTATGGTTCTTGTAAATGCCATTTACTTCAAAGGATTCTGGACCTATCAATTTG
ATCCAAAAGCAACATTCAAAGCACCATTCTTTCTCAATGATAATGATAAAGTTGATGTTG
ATTTCATGAAAATTAAGAAACATTTCAAATATGGACGATTTGATGATCTTGATGCAACTG
CATTGGAATTGCCTTACAAAGATTCTGATATTACAATGTTGATAATTTTACCAAATAAAC
GCACTGGATTGGCTGAATTGGAGAGCAAATTGGACACAATTGACTTCAATGAGCTCACAA
CAAAGATGTATTCGGAAGAAGTTAATGTTGAATTGCCAAAGTTTAAAATTGAATTTGACA
TTGAATTGACCGAGCCATTAAAGAAGGTTTGATAATTAACTTGCGAAAATATTTTGAACT
TGATAATTTTCTTTGGAAACTAATGTGAAATGTTTTTTTATATTTAGATGGGAATGGAGA
AAATGTTCTCAGATGCTGCTCAATTT
>g2453.t174 Gene=g2453 Length=169
MKGYSVKPTFQQVATKSFNSEAEDVNFAQSKDSADSLDADTRMVLVNAIYFKGFWTYQFD
PKATFKAPFFLNDNDKVDVDFMKIKKHFKYGRFDDLDATALELPYKDSDITMLIILPNKR
TGLAELESKLDTIDFNELTTKMYSEEVNVELPKFKIEFDIELTEPLKKV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g2453.t174 | Gene3D | G3DSA:3.30.497.10 | Antithrombin | 31 | 168 | 0.0e+00 |
| 6 | g2453.t174 | Gene3D | G3DSA:2.30.39.10 | - | 55 | 151 | 0.0e+00 |
| 2 | g2453.t174 | PANTHER | PTHR11461 | SERINE PROTEASE INHIBITOR, SERPIN | 34 | 168 | 0.0e+00 |
| 3 | g2453.t174 | PANTHER | PTHR11461:SF180 | LEUKOCYTE ELASTASE INHIBITOR | 34 | 168 | 0.0e+00 |
| 1 | g2453.t174 | Pfam | PF00079 | Serpin (serine protease inhibitor) | 36 | 168 | 0.0e+00 |
| 5 | g2453.t174 | SMART | SM00093 | serpin2 | 1 | 165 | 1.7e-05 |
| 4 | g2453.t174 | SUPERFAMILY | SSF56574 | Serpins | 2 | 168 | 0.0e+00 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005615 | extracellular space | CC |
| GO:0004867 | serine-type endopeptidase inhibitor activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed